首页> 外文期刊>Allergology international: official journal of the Japanese Society of Allergology >Sublingual Immunotherapy with House Dust Extract for House Dust-Mite Allergic Rhinitis in Children
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Sublingual Immunotherapy with House Dust Extract for House Dust-Mite Allergic Rhinitis in Children

机译:房尘提取物舌下免疫治疗儿童房尘螨过敏性鼻炎

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ABSTRACT Background House dust extract is used in conventional immunotherapy for house dust-mite (HDM) allergic rhinitis in Japan. However, an alternative administration route is desired. The aims of the present double blind, placebo-controlled trial were to evaluate the therapeutic efficacy and safety of sublingual immunotherapy (SLIT) with house dust extract in pediatric patients with HDM allergic rhinitis. Methods The study population comprised 31 subjects (21 males and 10 females) aged from 7 to 15 years old. Twenty patients (the active group) received house dust extract and 11 received placebo via sublingual administration. Extract or placebo (1 ml) was administered at 10-fold dilution once weekly for 40 weeks. During the study period, the subjects recorded their daily nasal symptoms and use (dose and frequency) of other medications in a nasal allergy diary. Results The symptom scores in the active group began to decrease about 24 weeks after initiation of treatment and significant differences between the active and placebo groups were observed after 30 weeks. The average scores for the last four weeks of the study were significantly lower than those for the first four weeks in the active group but not in the placebo group. The only local adverse effect was a bitter taste reported by one patient. There were no other local or systemic adverse effects associated with SLIT. Conclusions Our results suggest that SLIT with house dust extract for more than 30 weeks is safe and effective treatment for HDM allergic rhinitis in children.
机译:背景技术房屋尘埃提取物在日本用于房屋尘螨(HDM)过敏性鼻炎的常规免疫疗法中使用。但是,需要替代的给药途径。本双盲,安慰剂对照试验的目的是评估室内尘埃提取物对儿童HDM过敏性鼻炎的舌下免疫疗法(SLIT)的治疗效果和安全性。方法研究人群包括31位年龄在7至15岁之间的受试者(21位男性和10位女性)。 20名患者(活动组)通过舌下给药接受了室内除尘剂,而11名接受了安慰剂。提取液或安慰剂(1 ml)以10倍稀释度每周给药40周。在研究期间,受试者在鼻部过敏日记中记录了他们每天的鼻部症状和其他药物的使用(剂量和频率)。结果在开始治疗后约24周,活动组的症状评分开始下降,并且在30周后观察到活动组与安慰剂组之间的显着差异。在活动组中,研究的最后四周的平均得分显着低于前四周,但在安慰剂组中则没有。唯一的局部不良反应是一名患者报告的苦味。 SLIT没有其他局部或全身性不良反应。结论我们的研究结果表明,将SLIT与室内灰尘提取物一起使用30多个星期,对于儿童HDM过敏性鼻炎是安全有效的治疗方法。

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