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Drug Metabolism Letters

中文名称：药物代谢快报

ISSN：1872-3128
出版周期：Four no. a year

发文量：132

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1.A Multi-Endpoint Evaluation of Cytochrome P450 1A2, 2B6 and 3A4 Induction Response in Human Hepatocyte Cultures After Treatment with β - Naphthoflavone, Phenobarbital and Rifampicin

机译：β-萘黄酮，苯巴比妥和利福平治疗后人肝细胞培养物中细胞色素P450 1A2、2B6和3A4诱导反应的多端点评估
- 作者：J.G. Zhang* Thuy Ho Alanna L. Callendrello Charles L. Crespi and David M. Stresser
- 期刊名称：《Drug Metabolism Letters》 | 2010年第4期
- Cytochrome P450, induction;
- human hepatocytes, concentration and time-dependence.;
2.P-Glycoprotein and Breast Cancer Resistance Protein Affect Disposition of Tandutinib, A Tyrosine Kinase Inhibitor

机译：P-糖蛋白和乳腺癌耐药蛋白影响酪氨酸激酶抑制剂坦度替尼的配置
- 作者：Johnny J. Yang* Mark N. Milton Shaoxia Yu Mingxiang Liao Ning Liu Jing-Tao Wu
- 期刊名称：《Drug Metabolism Letters》 | 2010年第4期
- Tandutinib, P-gp, BCRP, drug disposition, pharmacokinetics, transporter knock-out mouse, rat;
3.Two Branched Polar Groups and Polar Linker Moieties of Thiophene Amide Derivatives Are Essential for MRP2/ABCC2 Recognition

机译：噻吩酰胺衍生物的两个分支极性基团和极性连接基部分对于MRP2 / ABCC2识别至关重要
- 作者：Yiding Hu Kathleen E. Sampson Li Xing Na Li Bruce R. Heyde Jin Xie and Yurong Lai
- 期刊名称：《Drug Metabolism Letters》 | 2010年第4期
- MRP2/ABCC2, structure-activity relationship, thiophene amide, biliary excretion, ADME.;
4.Molecular Analysis of the In Vivo Metabolism and Biodistribution of Metabolically and Non-Metabolically Activated Combi-Molecules of the Triazene Class

机译：三氮烯类代谢和非代谢活化的组合分子的体内代谢和生物分布的分子分析
- 作者：Qiyu Qiu Anne-Laure Larroque Bernard Gibbs Youqiang Fang Younes Lakhrissi Jean-Paul Soucy Shadreck Mzengeza Zakaria Rachid Bertrand J. Jean-Claude
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Combi-molecule, EGFR inhibition, DNA damage, In vivo;
5.Impact of Cerebral Malaria on Brain Distribution of Mefloquine

机译：脑型疟疾对甲氟喹脑分布的影响
- 作者：Sylvie Barraud de Lagerie Christine Fernandez Michele German-Fattal Jean-Charles Gantier Francois Gimenez Robert Farinotti
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Mefloquine, cerebral malaria, blood brain barrier, efflux, P glycoprotein, transporters;
6.Structure-Activity Relationship (SAR): Effort Towards Blocking NGlucuronidation of Indazoles (PF-03376056) By Human UGT1A Enzymes

机译：结构-活性关系（SAR）：努力通过人类UGT1A酶阻止吲唑的NG醛糖醛酸化（PF-03376056）
- 作者：Kelly Rose Young-Sun Yang Richard Sciotti Hongliang Cai
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- N-glucuronidation, Indazoles, UGT1A;
7.Impact of Time-Dependent Inactivation on the Estimation of Enzyme Kinetic Parameters for Midazolam

机译：时间依赖性灭活对咪达唑仑酶动力学参数估计的影响
- 作者：Craig Giragossian Jennifer LaPerle Rachel E. Kosa Sarah Gillian
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Enzyme kinetics, midazolam, mechanism based inactivation, time-dependent inactivation;
8.Inhibitory Effect of Codeine on Sucrase Activity

机译：可待因对蔗糖酶活性的抑制作用
- 作者：Dariush Minai-Tehrani Saeed Minoui Marzie Sepehre Zohre Sharif-Khodai Tooka Aavani
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Sucrase, inhibition, codeine, non-competitive, drug;
9.O-Demethylation of Dextromethorphan Using Microbial Cultures

机译：右美沙芬的O-脱甲基微生物培养
- 作者：Samathoti Prasanthi Maravajhala Vidyavathi Koganti V.S.R.G. Prasad Devarakonda Rama Krishna
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- CYP 2D6, dextromethorphan, dextrorphan, Microbial transformation, Oxidative demethylation, Saccharomyces cerevisiae;
10.Utility of Nicotiana tabacum Cell Suspension Cultures Expressing Human CYP1A1, CYP1A2 and CYP3A4 to Study the Oxidative Metabolism of the Herbicide 14C-Fluometuron

机译：表达人CYP1A1，CYP1A2和CYP3A4的烟草细胞悬浮培养物用于研究除草剂14C-氟草隆的氧化代谢的作用
- 作者：Maren Anne Breuer Burkhard Schmidt Ingolf Schuphan
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Nicotiana tabacum, metabolism, biotransformation, radio-TLC, radio-HPLC, human cyp1a1 cyp1a2, fluometuron;
11.Copper (II) Complexes of [1,2,4]Triazolo [1,5-a]Pyrimidine Derivatives as Potential Anti-Parasitic Agents

机译：[1,2,4]三唑[1,5-a]嘧啶衍生物的铜（II）配合物作为潜在的抗寄生虫药
- 作者：Samira Boutaleb-Charki Clotilde Marin Carmen R. Maldonado Maria J. Rosales Jesus Urbano Ramon Guitierrez-Sanchez Miguel Quiros Juan M. Salas Manuel Sanchez-Moreno
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Trypanosoma cruzi, Leishmania (Viannia) peruviana, triazolo-pyrimidine derivatives, anti-parasitic agents, action mechanism;
12.Study of Efficacy of Reactivator HI-6 in Reactivation of Immobilized Acetylcholinesterase, Inhibited by Organophosphorus Chemical Warfare Agents of the “G” Series

机译：HI-6活化剂对“ G”系列有机磷化学战剂抑制的固定化乙酰胆碱酯酶活化的功效研究
- 作者：Monika Hoskovcova Emil Halamek Zbynek Kobliha
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- Acetylcholinesterase, biosensors, enzyme inhibitors, enzyme reactivation, HI-6, organophosphorus warfare agents;
13.Co-Induction of CYP3A12 and 3A26 in Dog Liver Slices by Xenobiotics: Species Difference Between Human and Dog CYP3A Induction

机译：异种生物共同诱导狗肝切片中CYP3A12和3A26的诱导：人与狗CYP3A诱导的物种差异
- 作者：Jun Chen Cindy Tran Li Xiao Jairam Palamanda Thomas Klapmuts Pramila Kumari Xinjie Lin Er-jia Wang Yi-Zhong Gu Mary Humphries Annette S. Uss K.-C. Cheng
- 期刊名称：《Drug Metabolism Letters》 | 2009年第1期
- CYP 3A induction, pregnane X receptor, species difference;
14.High-Throughput Evaluation of CYP1A1 and 2B1 Induction in Rat Liver Slices Using a Semi-Automated System

机译：使用半自动化系统高通量评估大鼠肝切片中CYP1A1和2B1的诱导
- 作者：Jairam R. Palamanda Xinjie Lin Pramila Kumari Amin A. Nomeir
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Automation, HTP or High Throughput, Liver Slices, Real Time PCR, Cytochrome P450, Induction, CYP1A1, CYP2B1;
15.Inhibition of Human Aromatase by Myosmine

机译：肌氨酸对人芳香酶的抑制作用
- 作者：Irene L. Doering Elmar Richter
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- CYP19, cytochrome P450, human aromatase, myosmine, nicotine;
16.Differences in Lopinavir Plasma Concentrations Comparing Kaletra® Film Coated Tablets and Soft Gelatine Capsules That Result in Various Lipid Abnormalities

机译：比较Kaletra®薄膜衣片和明胶软胶囊导致洛平那韦血浆浓度的差异，导致各种脂质异常
- 作者：Judit Morello Vincent Soriano Francisco Blanco Antonio J. Rubio Inmaculada Jimenez-Nacher Sonia Rodriguez-Novoa
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Lopinavir, pharmacokinetics, metabolic complications, dislipidemia, cardiovascular risk, HIV;
17.Esterase Activities in the Blood, Liver and Intestine of Several Preclinical Species and Humans

机译：几种临床前物种和人类的血液，肝脏和肠道中的酯酶活性
- 作者：Loren M. Berry Lance Wollenberg Zhiyang Zhao
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Carboxylesterase, cholinesterase, paraoxonase, species difference;
18.Inhibitory Properties of Trapping Agents: Glutathione, Potassium Cyanide, and Methoxylamine, Against Major Human Cytochrome P450 Isoforms

机译：诱捕剂谷胱甘肽，氰化钾和甲氧基胺对主要的人类细胞色素P450异构体的抑制特性
- 作者：Chenghong Zhang Susan Wong Erlie M. Delarosa Jane R. Kenny Jason S. Halladay Cornelis E. Hop Siamak Cyrus Khojasteh-Bakht
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Trapping agents, glutathione, cyanide, methoxylamine, P450 inhibition, reactive metabolites;
19.High Throughput Quantitative Assessment of CYP Inactivation Using 2 Concentration Points

机译：CYP灭活的高通量定量评估，使用两个浓度点
- 作者：Daniel Albaugh Thomas Farrell Michael Langan W. George Lai
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Cytochrome P450, enzyme inactivation, KI, kinact;
20.Electronic and Structural Aspects of P450-Mediated Drug Metabolism

机译：P450介导的药物代谢的电子和结构方面
- 作者：David F.V. Lewis Yuko Ito Brian G. Lake
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
21.Glucuronidation of Buprenorphine and Norbuprenorphine by Human Liver Microsomes and UDP-Glucuronosyltransferases

机译：人肝微粒体和UDP-葡萄糖醛酸转移酶对丁丙诺啡和去甲丁丙诺啡的葡萄糖醛酸化作用
- 作者：Yan Chang David E. Moody
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Buprenorphine, glucuronidation, nonspecific protein binding, human liver microsome, UDP-glucuronosyltransferase, LC-MS/MS;
22.A Comparative Study on the Stability of Silybin and That in Silymarin in Buffers and Biological Fluids

机译：水飞蓟宾和水飞蓟素在缓冲液和生物液中的稳定性比较研究
- 作者：Ning Tang Danni Wu Yi Lu Jian Chen Bei Zhang Wei Wu
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Stability, silybin, silymarin, buffer, biological fluid, synergy;
23.Enhanced Hepatic and Kidney Cytochrome P-450 Activities in Nandrolone Decanoate Treated Albino Mice

机译：Nandrolone Decanoate处理的白化病小鼠的肝脏和肾脏细胞色素P-450活性增强。
- 作者：B. K. Acharjee R. Mahanta
- 期刊名称：《Drug Metabolism Letters》 | 2009年第2期
- Anabolic steroid, nandrolone decanoate, cytochrome P-450, liver, kidney;
24.Effect of Albendazole Administration on Pharmacokinetic Aspects of Tylosin in Lactating Goats

机译：阿苯达唑对泌乳山羊泰乐菌素药代动力学方面的影响
- 作者：M. Atef A. Ramadan A. S. Darwish Aisha M.M. Fahim
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Drug interaction, lactation, pharmacokinetics, macrolides, benzimidazole;
25.A Study of the Chemiluminescence Behavior of Cephalosporins with Luminol and Its Analytical Application

机译：头孢菌素与鲁米诺化学发光行为的研究及其分析应用
- 作者：Lichuan Niu Zhenghua Song Xili He
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Chemiluminescence, cephalosporins, luminol, urine, serum, excretion;
26.Quantitative Interference by Cysteine and N-Acetylcysteine Metabolites During the LC-MS/MS Bioanalysis of a Small Molecule

机译：半胱氨酸和N-乙酰半胱氨酸代谢产物在小分子LC-MS / MS生物分析过程中的定量干扰
- 作者：Jason Barricklow Tim F. Ryder Michael T. Furlong
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Quantification, metabolite, cysteine, interference, chromatography, co-elution;
27.Revisiting the Metabolism of Ketoconazole Using Accurate Mass

机译：使用精确质量重新研究酮康唑的代谢
- 作者：William L. Fitch Thuy Tran May Young Liling Liu Yuan Chen
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Ketoconazole, metabolism, mass spectrometry, deuterium labeling;
28.Studies of Acetaminophen and Metabolites in Urine and Their Correlations with Toxicity Using Metabolomics

机译：代谢组学研究尿液中对乙酰氨基酚和代谢物及其与毒性的关系
- 作者：Jinchun Sun Laura K. Schnackenberg Richard D. Beger
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Acetaminophen, metabolite profile, liquid chromatography/mass spectrometry (LC/MS), NMR, principal component analysis, toxicity;
29.Metabolism of Loratadine and Further Characterization of Its In Vitro Metabolites

机译：氯雷他定的代谢及其体外代谢产物的进一步表征
- 作者：Anima Ghosal Samir Gupta Ragu Ramanathan Yuan Yuan Xiaowen Lu Ai Duen (Iris) Su Narciso Alvarez Shmuel Zbaida Swapan K. Chowdhury Kevin B. Alton
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Loratadine, desloratadine, CYP3A4, CYP2D6, CYP2C19;
30.Comparison of Pharmacokinetics of Cyclosporine A in Cadaveric and Living- Related Renal Transplant Recipients and in an Experimental Rat Model of Renal Failure

机译：环孢菌素A在尸体和与生活有关的肾移植受者和实验性肾衰竭大鼠模型中的药代动力学比较
- 作者：Nobuyuki Sugioka Katsukuni Fujimoto Yuka Tanaka Keizo Fukushima Yukako Ito Takatoshi Kokuhu Masahiko Okamoto Norio Yoshimura Kanji Takada
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Cyclosporine A, pharmacokinetics, cadaveric renal transplantation, living-related renal renal transplantation, ischemia-reperfusion, rats;
31.Evaluation of CYP1A1 and CYP2B1/2 m-RNA Induction in Rat Liver Slices Using the NanoString® Technology: A Novel Tool for Drug Discovery Lead Optimization

机译：使用NanoString®技术评估大鼠肝切片中CYP1A1和CYP2B1 / 2 m-RNA的诱导：药物发现线索优化的新工具
- 作者：Jairam R. Palamanda Pramila Kumari Nicholas Murgolo Larry Benbow Xinjie Lin Amin A. Nomeir
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- NanoString®, Automation, HTP or High Throughput, Liver Slices, Real Time PCR, Cytochrome P450, Induction, CYP1A1, CYP2B1/2;
32.Fatal Lactic Acidosis Precipitated by Nifedipine in a Patient Treated with Disulfiram and Antiretrovirals

机译：硝苯地平在双硫仑和抗逆转录病毒药物治疗的患者中导致致命性乳酸酸中毒
- 作者：Oswald Moling Giovanni Rimenti Raffaele Pristera Claudio Vedovelli Leonardo Pagani Greta Spoladore Peter Mian
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- Lactic acidosis, nifedipine, disulfiram, amitriptyline, ritonavir, HIV;
33.Genetic Polymorphisms in UDP-Glucuronosyltransferase 1A6 Are Not Associated with NSAIDs-Related Peptic Ulcer Haemorrhage

机译：UDP-葡萄糖醛酸转移酶1A6的遗传多态性与NSAIDs相关的消化性溃疡出血不相关。
- 作者：Martijn G.H. van Oijen Marjolein I.A. Koetsier Robert J.F. Laheij Hennie M.J. Roelofs Rene H.M. te Morsche Wilbert H.M. Peters Freek W.A. Verheugt Jan B.M.J. Jansen Joost P.H. Drenth
- 期刊名称：《Drug Metabolism Letters》 | 2009年第3期
- UDP-glucuronosyltransferase 1A6, upper gastrointestinal symptoms, upper gastrointestinal bleeding, non-steroidal anti-inflammatory drugs, aspirin, genetic polymorphism;
34.Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes

机译：他喷他多在人肝微粒体和新鲜人肝细胞中的药物相互作用潜力的研究
- 作者：Christa Kneip Rolf Terlinden Horst Beier Genfu Chen
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation;
35.Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry

机译：MALDIImaging质谱法可视化特非那定的首过药物代谢
- 作者：Yunsheng Hsieh Jiwen Chen Ian Knemeyer Lee Crossman Walter A. Korfmacher
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Imaging mass spectrometry, MALDI, first-pass metabolism;
36.Rapid and Sensitive Characterization of the Metabolite Formation Enzyme Kinetics of Radiolabeled Drugs Using Stop-Flow Liquid Radiochromatography

机译：使用停止流液相色谱法快速灵敏地表征放射性标记药物的代谢物形成酶动力学
- 作者：Lifei Wang Weiping Zhao Donglu Zhang Mingshe Zhu
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Stop-flow RFD, enzyme kinetics, liquid radiochromatography;
37.Time and Dose Dependent Study of Doxorubicin Induced DU-145 Cytotoxicity

机译：阿霉素诱导DU-145细胞毒性的时间和剂量依赖性研究
- 作者：Saeed S. Al-Ghamdi
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Doxorubicin, DU-145, cytotoxicity;
38.An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

机译：评估人肝微粒体中CYP3A4，CYP2D6和CYP2C9的时间依赖性抑制的IC50和IC50位移实验的检查
- 作者：Loren M. Berry Zhiyang Zhao
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Cytochrome P450, drug interactions, in vitro models, inhibition, microsomes, time-dependent inactivation;
39.Phenotyping of Cytochrome P450 3A Enzyme in Gujarat Population

机译：古吉拉特邦人口中的细胞色素P450 3A酶的表型分析
- 作者：Ashutosh J. Jani Shivprakash Rathnam Anita A. Mehta
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Cytochrome P450, atorvastatin, phenotype, gujarati, CYP3A4;
40.Renal and Hepatic Transporter Expression in Type 2 Diabetic Rats

机译：肾和肝转运蛋白在2型糖尿病大鼠中的表达
- 作者：Jose E. Manautou Michael T. Nowicki Lauren M. Aleksunes Sharmilee P. Sawant Ankur V. Dnyanmote Harihara M. Mehendale
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Diabetes, xenobiotic transporters, drug disposition, streptozotocin;
41.Allelic Variations in 5, 10-Methylenetetrahydrofolate Reductase Gene and Susceptibility to Cervical Cancer in Indian Women

机译：5，10-亚甲基四氢叶酸还原酶基因的等位基因变异和对印度女性宫颈癌的易感性
- 作者：Samar Husain Naqvi Naveen Kumar Nandan Saima Wajid Shilpie Biswas Sominder Singh Juneja Moshahid Rizvi Raminder Prakash
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- DNA methylation, MTHFR loci, polymorphism, cervical intraepithelial, Mutation;
42.Pharmacokinetics of Ceftriaxone in Carbontetrachloride-Induced Hepatopathic and Uranyl nitrate-Induced Nephropathic Goats Following Single Dose Intravenous Administration

机译：单剂静脉给药后头孢曲松在四氯化碳诱导的肝病和硝酸铀酰诱导的肾病山羊中的药代动力学
- 作者：Tapan Kumar Mandal Tapas Kumar Sar Shymal Kumar Das Animesh Kumar Chakraborty
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Pharmacokinetics, ceftriaxone, ceftizoxime, carbontetrachloride-induced hepatopathy, uranyl nitrate-induced nephropathy, goats;
43.Modulation of Porcine (Sus scrofa domestica) and Pheasant (Phasianus colchicus) Carbonyl Reducing Enzymes by Anthelmintic Therapy with Flubendazole

机译：氟苯达唑的驱虫治疗对猪和野鸡羰基还原酶的调节
- 作者：Barbora Szotakova Milan Nobilis Jiri Lamka Veronika Krizova Michal Savlik Lenka Skalova
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Pig, pheasant, anthelmintics, flubendazole, enzyme modulation;
44.Identification of a Novel Glutathione Conjugate of Diclofenac by LTQOrbitrap

机译：LTQOrbitrap鉴定新型双氯芬酸谷胱甘肽结合物
- 作者：Yohannes Teffera Daniel J. Waldon Adria E. Colletti Brian K. Albrecht Zhiyang Zhao
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- glutathione adduct, DPABA, diclofenac decarboxylation, Bioactivation pathway, Reconstructed ion chromatogram;
45.Induction of Cytochrome P450 3A by the Ginkgo biloba Extract and Bilobalides in Human and Rat Primary Hepatocytes

机译：银杏叶提取物和双叶内酯在人和大鼠原代肝细胞中诱导细胞色素P450 3A的表达
- 作者：Shu-Feng Zhou Ying Deng Hui-chang Bi Li-zi Zhao Xue-ding Wang Jie Chen Zhi-min Ou Liang Ding Le-jia Xu Su Guan Xiao Chen Min Huang
- 期刊名称：《Drug Metabolism Letters》 | 2008年第1期
- Ginkgo biloba extract, bilobalide, ginkgolide B, cytochrome P450, CYP3A, induction, human and rat primary hepatocytes;
46.Synthesis and Evaluation of Macromolecule-Bound Derivatives of a Peptidyl-1-ß-D-arabinofuranosylcytosine Prodrug

机译：肽-1-ß-D-阿拉伯呋喃糖基胞嘧啶前药大分子结合衍生物的合成和评价
- 作者：Zoltan Balajthy
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Ara-C, prodrug, dextran, macromolecule conjugates;
47.Brain-to-Plasma Distribution Ratio of the Biflavone Amentoflavone in the Mouse

机译：小鼠中双黄酮Amentoflavone的脑对血浆分布比率
- 作者：Milena Colovic Claudia Fracasso Silvio Caccia
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Amentoflavone, pharmacokinetics, brain-to-plasma ratio, PgP, mouse;
48.The Effects of the 3,4-Methylenedioxymethamphetamine (Ecstasy) in Some Cerebral Areas: Role of the Oxidative Stress

机译：3，4-亚甲基二氧基甲基苯丙胺（摇头丸）在某些脑区的影响：氧化应激的作用。
- 作者：Sergio Franzese Anna Capasso
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- MDMA;
- toxicity;
- cellular oxidative stress;
49.Analysis of Flavin-Containing Monooxygenase 3 Genotype Data in Populations Administered the Anti-Schizophrenia Agent Olanzapine

机译：抗精神分裂症药物奥氮平人群中黄素含量高的单加氧酶3基因型数据分析
- 作者：John R. Cashman Jun Zhang Matthew R. Nelson Andreas Braun
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Olanzapine, flavin-containing monooxygenase-3, pharmacogenetics, schizophrenia, side effects, delusions, hallucinations, ethnic groups;
50.Effect of Folic Acid on Methotrexate Induction of Sulfotransferases in Rats

机译：叶酸对大鼠甲氨蝶呤诱导的磺基转移酶的影响
- 作者：Sangita Maiti Dutta Smarajit Maiti Guangping Chen
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Methotrexate, folic acid, induction, sulfotransferase, STa, AST-IV;
51.The Use of 1-Aminobenzotriazole in Differentiating the Role of CYPMediated First Pass Metabolism and Absorption in Limiting Drug Oral Bioavailability: A Case Study

机译：1-氨基苯并三唑在区分CYP介导的首过代谢和吸收在限制药物口服生物利用度中的作用的案例研究
- 作者：Ayman F. El-Kattan Julie Poe Lisa Buchholz Hayden V. Thomas Joanne Brodfuehrer Alan Clark
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- 1-aminobenzotriazole, bioavailability, first pass effect, absorption;
52.Stability of Methadone and Its Main Metabolite in Oral Fluid

机译：美沙酮及其主要代谢产物在口服液中的稳定性
- 作者：Nadia Fucci Nadia De Giovanni
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Saliva, methadone, stability, SPME-GC/MS;
53.Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

机译：十四烷基硫代乙酸的长期治疗可改善肥胖Zucker（fa / fa）大鼠的抗氧化状态
- 作者：Hege Wergedahl Kjetil Berge Pavol Bohov Karl-Johan Tronstad Lise Madsen Rolf K. Berge
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde;
54.Pharmacokinetics and Metabolism of Diltiazem Following Multiple Doses:Comparing Normotensive Rat vs. Hypertensive Rat Models In vivo

机译：地尔硫卓多次给药后的药代动力学和代谢：体内血压正常大鼠与高血压大鼠的比较
- 作者：Pollen K.F. Yeung Angelita Alcos Jinglan Tang William l. Casley
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Metabolism, pharmacokinetics, diltiazem, rats, SHR;
55.Influence of ABCB1 Gene Polymorphisms and P-Glycoprotein Activity on Cyclosporine Pharmacokinetics in Peripheral Blood Mononuclear Cells in Healthy Volunteers

机译：ABCB1基因多态性和P-糖蛋白活性对健康志愿者外周血单个核细胞中环孢菌素药代动力学的影响
- 作者：Nicolas Ansermot Michela Rebsamen Jocelyne Chabert Marc Fathi Marianne Gex-Fabry Youssef Daali Marie Besson Michel Rossier Serge Rudaz Denis Hochstrasser Pierre Dayer Jules Desmeules
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Cyclosporine, PBMCs, ABCB1, P-Glycoprotein, pharmacokinetics, TDM, pharmacogenetics;
56.Quantitative Structure-Retention-Pharmacokinetic Relationship Studies

机译：定量结构-保留-药代动力学关系研究
- 作者：Snezana Agatonovic-Kustrin Joseph V. Turner Beverley D. Glass
- 期刊名称：《Drug Metabolism Letters》 | 2008年第2期
- Theoretical descriptors, generalized ANN, QSPR, physicochemical parameter;
57.Aldehyde Oxidase Activity and Inhibition in Hepatocytes and Cytosolic Fraction from Mouse, Rat,Monkey and Human

机译：小鼠，大鼠，猴和人肝细胞和细胞溶质中乙醛氧化酶的活性和抑制作用
- 作者：Jasminder Sahi Kishore K. Khan Chris B. Black
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- Aldehyde oxidase, cytosole, cryopreserved hepatocytes, cross-species;
58.Effects of Enzyme Sources on Midazolam 1-Hydroxylation Activity Catalyzed by Recombinant Cytochrome P450 3A4 in Combination with NADPH-Cytochrome P450 Reductase

机译：酶源对重组细胞色素P450 3A4和NADPH-细胞色素P450还原酶催化的咪达唑仑1-羟基氧化活性的影响
- 作者：Chie Emoto Norie Murayama Hiroshi Yamazaki
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- CYP3A4, lipid mixtures, NADPH-P450 reductase, bicistronic expression, E. coli membranes, human;
59.Oxidative Bioactivation and Toxicity of Leflunomide in Immortalized Human Hepatocytes and Kinetics of the Non-Enzymatic to Its Major etabolitie, A77 1726

机译：来氟米特在永生化人肝细胞中的氧化生物活化和毒性以及主要酶代谢的非酶动力学，A77 1726
- 作者：Quee Ming Seah Lee-Sun New Eric C.Y. Chan Urs A. Boeslsterli
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- Leflunomide, A77 1726, human hepatocytes, bioactivation, hepatotoxicity;
60.Microsome Biocolloids for Rapid Drug Metabolism and in hibition Assessment by LC-MS

机译：微粒体生物胶体，用于快速药物代谢和LC-MS抑制评估
- 作者：Besnik Bajrami Sadagopan Krishnan James F. Rusling
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- Microsome-biocolloids, N-nitrosamines, inhibition, cap-LC/MS, CYP, Ketoconazole;
61.Effects of Cyclosporine A and Itraconazole on Permeability, Biliary Excretion and Pharmacokinetics of Amlidipine

机译：环孢菌素A和伊曲康唑对氨氯地平通透性，胆汁排泄和药代动力学的影响
- 作者：Liang Ni Xue Yu Qiaoling Yu Xijing Chen Lee Jia
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- Amlodipine, cyclosporin A, itraconazole, P-glycoprotein, CYP3A, permeability, biliary exretion, pharmacokinerics;
62.Quantitative Relationship Between Rifampicin Exposure and Induction of CYP3a11 in SXR Humanized Mice: Extrapolation to Human CYP3A4 Induction Potential

机译：SXR人源化小鼠中利福平暴露与CYP3a11诱导之间的定量关系：外推至人CYP3A4诱导潜力
- 作者：Sean Kim Devin Pray Ming Zheng Danial G. Morgan Jenifer G. Pizzano Mary E. Zoeckler Anjaneya Chimalakonda Michael W. Sinz
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- CYP induction, SXR-humanized mouse, rifampicin, drug-drug interaction, CYP3A4, CYP3A11;
63.Troglitazone Thiol Adduct Formation in Human Liver Microsomes: Enzyme Knietics and Reaction Phenotyping

机译：人类肝脏微粒体中曲格列酮硫醇加合物的形成：酶动力学和反应表型
- 作者：Jinping Gan Qinling Qu Bing He Wen C. Shyu A. David Rodrigues Kan He
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- Troglitazone, reactive metabolite, reaction phenotyping, CYP3A4, CYP2C8;
64.Proposed New Addition to 3Rs for Ethical and Humane Use of Rats in Pharmacokinetic Studies – ‘Recycle’

机译：在药代动力学研究中建议对大鼠进行伦理和人道使用的3R的新补充-“回收”
- 作者：Suresh K. Balani Chaung Lu Kym Cardoza Cicely Berg Ji Zhang Frank W. Lee
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- 3Rs, Reduction, Replacement, Refinement, Recycle, 4Rs, Pharmacokinetics;
65.Allosteric Modulation of SULT2A1 by Celecoxib and Nimesulide: Computational Analyses

机译：塞来昔布和尼美舒利对SULT2A1的变构调节：计算分析。
- 作者：Emine Bihter Yalcin Scott M. Struzik Roberta S. King
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- Estradiol, sulfotransferase, allosteric, docking, metabolism, Autodock 4;
66.Assessment of Cytochrome P450 Induction in Human Hepatocytes Using the Cocktail Strategy Plus Liquid Chromatography Tandem Mass Spectrometry

机译：使用鸡尾酒策略加液相色谱串联质谱法评估人肝细胞中细胞色素P450的诱导
- 作者：Agustin Lahoz Maria Teresa Donato Laura Picazo Jose V. Castell Maria Jose Gomez-Lechon
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- HPLC-MS/MS, CYP cocktail, drug induction, human hepatocytes, 96-well plates;
67.Absolute Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase (UGT) Enzyme Isoforms 1A1 and 1A6 By Tandem LC-MS

机译：通过串联LC-MS绝对定量人尿苷二磷酸葡萄糖醛糖基转移酶（UGT）酶同工型1A1和1A6
- 作者：John K. Fallon David E. Harbourt Saber H. Maleki Fay K. Kessler Joseph K. Ritter Philip C. Smith
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- LC-MS/MS, UGT, triple quadrupole, absolute quantification, quantitative proteomics, stable isotope labeled synthetic peptides;
68.Role of P-glycoprotein in the Transport of Tanshinone I, One Active Triterpenoid from Salvia miltiorrhiza

机译：P糖蛋白在丹参中一种活性三萜类化合物丹参酮I转运中的作用
- 作者：Xing-Xiao Li Zhi-Wei Zhou Shu-Feng Zhou
- 期刊名称：《Drug Metabolism Letters》 | 2008年第3期
- P-glycoprotein, tanshinone IIB, intestinal absorption, multidrug resistance associated protein 1, Tanshinone I, Pglycoprotein, Caco-2, Permeability;
69.Identification of Four Urea Adducts of Andrographolide in Humans

机译：人体中穿心莲内酯的四种尿素加合物的鉴定
- 作者：Liang Cui Wan Chan Feng Qiu Zongwei Cai Xinsheng Yao
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Andrographolide, metabolites, urea adducts, human urine, NMR, HRSI-MS;
70.Increase of R-/S-Methadone Enantiomer Concentration Ratio in Serum of Patients Treated with Either Nevirapine or Efavirenz

机译：奈韦拉平或依非韦伦治疗的患者血清中R- / S-美沙酮对映体浓度比的增加
- 作者：Javier Esteban Maria de la Cruz Pellin Carmen Gimeno Jose Barril Jesus Gimenez Eva Mora Adolfo G. Garcia-Perez
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Methadone, nevirapine, efavirenz, CYP3A4, CYP2B6, hepatitis C Virus;
71.Synthesis of Haloperidol Prodrugs and Their Hydrolysis by Porcine Liver Esterase

机译：氟哌啶醇前药的合成及其猪肝酯酶的水解作用
- 作者：Andrew P. Morris Keith R. Brain Charles M. Heard
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Haloperidol, prodrug, ester, porcine liver esterase, transdermal, hydrolysis;
72.Covariates of Amikacin Clearance in Neonates: The Impact of Postnatal Age on Predictability

机译：新生儿阿米卡星清除率的协变量：产后年龄对可预测性的影响
- 作者：Karel Allegaert Isabelle Scheers Veerle Cossey Brian J. Anderson
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Ontogeny, renal drug clearance, amikacin, covariates, predictability;
73.Drug Testing by Chemical Analysis of Fingerprint Deposits from Methadone- Maintained Opioid Dependent Patients Using UPLC-MS/MS

机译：使用UPLC-MS / MS通过美沙酮维持的阿片类药物依赖患者的指纹沉积物的化学分析进行药物测试
- 作者：Shana Jacob Sue Jickells Kim Wolff Norman Smith
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Chemical analysis, fingerprint, methadone, opioid, UPLCMS/ MS, metabolite, EDDP, drug;
74.Study of Oxidized Lipids as Endogenous Substrates of P-gp (ABCB1)

机译：作为P-gp（ABCB1）内源性底物的氧化脂质的研究
- 作者：Masatoshi Masuda Emi Nakai Takaharu Mizutani
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- MDR1, P-glycoprotein, ABCB1, Sphingolipid, GM1-ganglioside, ROS;
75.Effect of the Acute Phase Response Induced by Endotoxin Administration on the Expression and Activity of UGT Isoforms in Rats

机译：内毒素引起的急性期反应对大鼠UGT亚型表达和活性的影响
- 作者：Khalid M. Alkharfy Samuel M. Poloyac Mario Congiu Paul V. Desmond Reginald F. Frye
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Endotoxin, LPS, acute phase response, glucuronidation, UGT;
76.Pharmacokinetic and Pharmacodynamic Predictions of Novel Potential HIV-1 Integrase Inhibitors

机译：新型潜在HIV-1整合酶抑制剂的药代动力学和药效学预测。
- 作者：C.H. T.P. da Silva V.B. da Silva C. A. Taft
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Pharmacodynamic, HIV-1 Integrase Inhibitors, Virtual screening, metabolism, computational chemistry;
77.Decreased Valproate Level Caused by VPA-glucuronidase Inhibition by Carbapenem Antibiotics

机译：碳青霉烯类抗生素对VPA-葡萄糖醛酸苷酶的抑制作用导致丙戊酸水平降低
- 作者：Yutaka Nakamura Keiko Nakahira Takaharu Mizutani
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Valproic acid, epilepsy, carbapenem antibiotics, glucuronidase, panipenem;
78.Heme Oxygenase-Derived Carbon Monoxide Restores Vascular Function in Type 1 Diabetes

机译：血红素加氧酶衍生的一氧化碳可恢复1型糖尿病的血管功能。
- 作者：Luigi F. Rodella Luca Vanella Stephen J. Peterson George Drummond Rita Rezzani John R. Falck Nader G. Abraham
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- Vascular repair, diabetes, thrombomodulin, adiponectin, inflammation, carbon monoxide;
79.In Vitro Metabolism Studies of New Adenosine A Receptor Antagonists

机译：新腺苷A受体拮抗剂的体外代谢研究
- 作者：Gabriella Marucci Sara Finaurini Michela Buccioni Carmen Lammi Meenakshisundaram Kandhavelu Rosaria Volpini Massimo Ricciutelli Piero Angeli Jan N.M. Commandeur Gloria Cristalli
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- A2A antagonist, A2A adenosine receptors, rat microsome hepatocytes, CYP2D6, 8-substituted 9-ethyladenine, Parkinson's disease, HPLC;
80.Induction of Human UGT1A1 by Bilirubin Through AhR Dependent Pathway

机译：胆红素通过AhR依赖性途径诱导人UGT1A1
- 作者：Hiroshi Togawa Shigeko Shinkai Takaharu Mizutani
- 期刊名称：《Drug Metabolism Letters》 | 2008年第4期
- UDP-glucuronosyltransferase, UGT1A1, bilirubin, aryl hydrocarbon receptor, xenobiotic responsive element;
81.Verapamil, but not Probenecid, Co-Administration Can Convert Desloratadine to a Sedating Antihistamine in Mice

机译：维拉帕米（而非丙磺舒）共同给药可将地氯雷他定转化为小鼠中的镇静抗组胺药
- 作者：Anand Katta Mugunthu Dhananjeyan Crystal Bykowski Paul Erhardt Miles Hacker Donald B. White Kenneth Bachmann
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- PgP, desloratadine, antihistamines, pharmacokinetics, pharmacodynamics;
82.Drug Interactions of Tipranavir, a New HIV Protease Inhibitor

机译：Tipranavir，一种新型的HIV蛋白酶抑制剂的药物相互作用
- 作者：Judit Morello Sonia Rodriguez-Novoa Inmaculada Jimenez-Nacher Vincent Soriano
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Tipranavir, HIV, drug interactions, protease inhibitors;
83.Effect of Common NAT2 Variant Alleles in the Acetylation of the Major Clonazepam Metabolite, 7-minoclonazepam

机译：常见的NAT2变异等位基因在主要Clonazepam代谢产物7-minoclonazepam乙酰化中的作用
- 作者：M. Olivera C. Martinez G. Gervasini J. A. Carrillo S. Ramos J. Benitez E. Garcia-Martin J. A. G. Agundez
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- NAT2, acetylation, polymorphism, pharmacogenomics;
84.A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans

机译：药物代谢的一个独特例子：大鼠，狗和人类中己内酰胺的四氧合和五氧合反应
- 作者：Hai-Zhi Bu William F. Pool Ellen Y. Wu Bhasker V. Shetty
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Capravirine, oxygenation, metabolism, structure elucidation, profiling, identification, biotransformation;
85.Metabolic Stability Screen for Drug Discovery Using Cassette Analysis and Column Switching

机译：使用盒式分析和柱切换技术进行药物发现的代谢稳定性屏幕
- 作者：Jason S. Halladay Susan Wong Sharmin M. Jaffer Achintya K. Sinhababu S. Cyrus Khojasteh-Bakht
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Metabolic stability, in vitro, liver microsomes, ADME, column switching, cassette analysis;
86.EDITORIAL

机译：社论
- 作者：Chandra Prakash
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- EDITORIAL;
87.In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

机译：反式白藜芦醇的羟基代谢产物Piceatannol对大鼠CYP1A1和CYP1A2的体外抑制
- 作者：Thomas K. H. Chang Jie Chen Chia-Ting Yu
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- CYP1A1, CYP1A2, cytochrome P450, piceatannol, trans-resveratrol;
88.Comparison of Paraben Stability in Human and Rat Skin

机译：人和大鼠皮肤中对羟基苯甲酸酯稳定性的比较
- 作者：Heather M. Harville Richard Voorman Jeffery J. Prusakiewicz
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Paraben, esterase, skin, epidermal drug metabolism;
89.ABCB1, SLCO1B1 and UGT1A1 Gene Polymorphisms Are Associated with Toxicity Line Irinotecan

机译：ABCB1，SLCO1B1和UGT1A1基因多态性与毒性线伊立替康相关。
- 作者：Katrin E. Rhodes Wu Zhang Dongyun Yang Oliver A. Press Michael Gordon Daniel Vallbohmer Anne M. Schultheis Georg Lurje Robert D. Ladner William Fazzone Heinz-Josef Lenz Syma Iqbal
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Polymorphisms, colorectal cancer, toxicity, irinotecan;
90.Prioritization of Clinical Drug Interaction Studies Using In Vitro Cytochrome P450 Data:“Rank Order” Approach

机译：使用体外细胞色素P450数据的临床药物相互作用研究的优先次序：“等级排序”方法
- 作者：A. David Rodrigues
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Cytochrome P450, classification, interactions, inhibition, in vitro, strategy;
91.Drug Confinement and Delivery in Ceramic Implants

机译：陶瓷植入物中的药物限制和递送
- 作者：Maria Vallet-Regi Francisco Balas Montserrat Colilla Miguel Manzano
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Bioceramics, bone tissue regeneration, drug-delivery, mesoporous materials;
92.Application of Pharmacogenomics in Drug Discovery and Development:Correlations Between Transcriptional Modulation and Preclinical Safety Observations

机译：药物基因组学在药物发现和开发中的应用：转录调控与临床前安全性观察之间的相关性
- 作者：Lilian G. Yengi Qian Xiang Li Shen Appavu Chandrasekaran John Kao JoAnn Scatina
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Non steroidal progestins, preclinical safety assessments, pharmacogenomics, systems biology approach, transcriptional regulation, thyroid hormone regulation;
93.A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis

机译：溶酶体磷脂酶A2在药物诱导的磷脂中的作用
- 作者：Akira Abe Miki Hiraoka James A. Shayman
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Cationic amphiphilic drug, amiodarone, PDMP, tetracycline, phospholipidosis, lysosomal phospholipase A2;
94.Folate Nutrigenetics: A Convergence of Dietary Folate Metabolism, Folic Acid Supplementation, and Folate Antagonist Pharmacogenetics

机译：叶酸营养遗传学：饮食中叶酸代谢，叶酸补充和叶酸拮抗剂药代动力学的融合。
- 作者：Brian Meshkin Kenneth Blum
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- neural tube defect, cardiovascular disease (CVD), methylenetetrahydrofolate reductase, methotrexate, MTHFR C677T genetic variant;
95.Structures of Various Cytochromes c Evaluated from the Redox Behaviors Using the Optically Active Co(III) Complex-Modified Au Electrode

机译：使用光学活性的Co（III）配合物修饰的Au电极从氧化还原行为评估各种细胞色素c的结构
- 作者：Takahashi Chika Nishijima Tomohiko Inomata Yasuhiro Funahashi Tomohiro Ozawa Hideki Masuda
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Cytochrome c, modified Au electrode, optically active CoIII complex, solution structure, electrochemical measurement, conformational change;
96.Effects of Propofol Analogs on Glucuronidation of Propofol, an Anesthetic Drug, by Human Liver Microsomes

机译：异丙酚类似物对人肝微粒体对麻醉药丙泊酚葡萄糖醛酸化的影响
- 作者：Makiko Shimizu Yoshiaki Matsumoto Hiroshi Yamazaki
- 期刊名称：《Drug Metabolism Letters》 | 2007年第1期
- Propofol, UGT1A9, inhibitor, glucuronidation, human, 2,5-diisopropylphenol;
97.A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans

机译：卡培他滨的葡萄糖醛酸化途径在大鼠中发生，但在小鼠和人类中不发生
- 作者：F. Desmoulin C. Claparols D. Bon G. Larrieu R. Martino M. Malet-Martino
- 期刊名称：《Drug Metabolism Letters》 | 2007年第2期
- Capecitabine, glucuronide, human, rat, mice, cytidine deaminase;
98.Assessment of Cryopreserved Hepatocytes as an Alternative to Fresh Hepatocytes forComparative InterspeciesMetabolism Studieswith Suitable Acceptance Criteria

机译：评估冷冻保存的肝细胞作为新鲜肝细胞的替代品，以进行种间比较代谢研究，并采用适当的接受标准
- 作者：Ziqiang (Zack) Cheng Christine E. Herron Gary Bowers Mark de Serres
- 期刊名称：《Drug Metabolism Letters》 | 2007年第2期
- Cryopreserved hepatocytes, fresh hepatocytes, comparative metabolism, metabolite profiling, structural identification, radiochemical flow detection;
99.Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications

机译：日本人群中多态性药物代谢酶的简要概述：高通量基因分型方法的发展和建议的应用程序。
- 作者：Takahiro Kubota
- 期刊名称：《Drug Metabolism Letters》 | 2007年第2期
- CYP2C9, CYP2C19, CYP2D6, thiopurine S-methyltransferase, glutathione S-transferase and sulfotransferase 1A1;
100.Disposition of Vorinostat, A Novel Histone Deacetylase Inhibitor and Anticancer Agent, in Preclinical Species

机译：新型组蛋白去乙酰化酶抑制剂和抗癌药伏立诺他在临床前物种中的处置
- 作者：Punam Sandhu Paul A. Andrews Maribeth P. Baker Kenneth A. Koeplinger Eric D. Soli Thomas Miller Thomas A. Baillie
- 期刊名称：《Drug Metabolism Letters》 | 2007年第2期
- Vorinostat, histone deacetylases, glucuronidation, β-oxidation, 4-anilino-4-oxobutanoic acid;

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