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RSC Medicinal Chemistry

中文名称：RSC药物化学

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共28条结果

1.Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases

机译：Pharmacophore-based筛选diamidine小蛋白质精氨酸分子抑制剂甲基转移酶
- 作者：Qian Kun;Yan Chunli;Su HairuiDang TranZhou BoWang ZhenyuZhao XinyangIvanov IvayloHo Meng-ChiaoZheng Y. George
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
2.MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization (Retraction of Vol 9, Pg 1359, 2018)

机译：促进成骨细胞的微rna - 451封锁分化和骨合成代谢的影响促进YWHAZ-mediated RUNX2蛋白质稳定(收缩的9卷,Pg 1359,2018)
- 作者：Lim Katie
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- Core Binding Factor Alpha 1 Subunit;
- Anabolic Effect;
- SkeletonsIndividualized Instruction;
3.Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

机译：向RIOK2化学探针:细胞的能力改善选择性2 -吡啶(acylamino)系列
- 作者：Wang Christopher B.;Lorente-Macias Alvaro;Wells CarrowPickett Julie E.Picado AlfredoZuercher William J.Axtman Alison D.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
4.Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents

机译：Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents
- 作者：Haranahalli Krupanandan;Tong Simon;Kim SaeromAwwa MonafChen LeiKnudson Susan E.Slayden Richard A.Singleton EricRusso RiccardoConnell NancyOjima Iwao
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
5.Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents

机译：Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents
- 作者：Fernandez de Luco Julia;Recio-Balsells Alejandro I;Ghiano Diego G.Bortolotti AnaManuel Belardinelli JuanLiu NinaHoffmann PascalLherbet ChristianTonge Peter J.Tekwani BabuMorbidoni Hector R.Labadie Guillermo R.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
6.Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues

机译：Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues
- 作者：Makukhin Nikolai;Ciulli Alessio
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- L-TYROSINE;
- PURIFICATION;
7.Identification of 3-hydroxy-1,2-dimethylpyridine4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A

机译：Identification of 3-hydroxy-1,2-dimethylpyridine4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A
- 作者：Lin Lucy;Turner Lewis D.;Silhar PeterPellett SabineJohnson Eric A.Janda Kim D.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
8.Structure guided generation of thieno3,2-d pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors

机译：结构引导代thieno (3 d)pyrimidin-4-amine结核分枝杆菌双相障碍氧化酶抑制剂
- 作者：Hopfner Sarah M.;Lee Bei Shi;Kalia Nitin P.Miller Marvin J.Pethe KevinMoraski Garrett C.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
9.Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

机译：Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series
- 作者：Wang Christopher B.;Lorente-Macias Alvaro;Wells CarrowPickett Julie E.Picado AlfredoZuercher William J.Axtman Alison D.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- PROTEIN-KINASE;
10.Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase

机译：Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase
- 作者：Kwai Brooke X. C.;Collins Annabelle J.;Middleditch Martin J.Sperry JonathanBashiri GhaderLeung Ivanhoe K. H.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
11.Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases

机译：Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases
- 作者：Qian Kun;Yan Chunli;Su HairuiDang TranZhou BoWang ZhenyuZhao XinyangIvanov IvayloHo Meng-ChiaoZheng Y. George
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- DNA-BINDING;
- CHEMICAL BIOLOGY;
- METHYLATION;
- DERIVATIVES;
- DISCOVERY;
- DOCKING;
- COMPLEX;
12.Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase

机译：Itaconate的共价抑制剂结核分枝杆菌异柠檬酸裂解酶
- 作者：Kwai Brooke X. C.;Collins Annabelle J.;Middleditch Martin J.Sperry JonathanBashiri GhaderLeung Ivanhoe K. H.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- itaconate;
- Mycobacterium tuberculosis;
- isocitrate lyaseCovalent Interaction;
13.Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?

机译：物理化学性质和分枝杆菌肺结核转运蛋白:有效的关键抗结核的药物吗?
- 作者：Fullam Elizabeth;Young Robert J.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
14.Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR

机译：Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR
- 作者：Riboldi Gustavo P.;Zigweid Rachael;Myler Peter J.Mayclin Stephen J.Counago Rafael M.Staker Bart L.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
15.Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds

机译：Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds
- 作者：Liu Rui;Markley Lowell;Miller Patricia A.Franzblau ScottShetye GauriMa RuiSavkova KarinMikusova KatarinaLee Bei ShiPethe KevinMoraski Garrett C.Miller Marvin J.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
16.Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues

机译：合成和药用的最新进展化学phosphotyrosine和phosphonate-based phosphotyrosine类似物
- 作者：Makukhin Nikolai;Ciulli Alessio
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- Phosphate coatings;
- Medicinal chemistry;
- SYNTHETICSPTB Domainphosphotyrosinewide-range;
17.Medicinal chemistry updates on quinoline- and endoperoxide-based hybrids with potent antimalarial activity

机译：药物化学喹啉和更新endoperoxide-based混合动力车和强有力的抗疟活性
- 作者：Uddin Amad;Chawla Meenal;Irfan IramMahajan ShubhraSingh ShailjaAbid Mohammad
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
18.Identification of 3-hydroxy-1,2-dimethylpyridine4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A

机译：的识别3-hydroxy-1 2-dimethylpyridine4 (1 h) -thione主题的抑制与肉毒神经毒素的
- 作者：Lin Lucy;Turner Lewis D.;Silhar PeterPellett SabineJohnson Eric A.Janda Kim D.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- warhead;
- Authentication;
- metal bindingBotulinum Toxins, Type Abotulinum neurotoxin;
19.Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds

机译：Hydride-induced Meisenheimer复杂地层反映了硝基芳香的活动抗结核的化合物
- 作者：Liu Rui;Markley Lowell;Miller Patricia A.Franzblau ScottShetye GauriMa RuiSavkova KarinMikusova KatarinaLee Bei ShiPethe KevinMoraski Garrett C.Miller Marvin J.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- TRANSIENT RESPONSE;
- Radiolabelling;
- ComplexationMeisenheimer complexesNitroarene Compound;
20.Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents

机译：探索的化学空间1 2 3-triazolyl三氯生对新发现的类似物antileishmanial化疗药物
- 作者：Fernandez de Luco Julia;Recio-Balsells Alejandro I;Ghiano Diego G.Bortolotti AnaManuel Belardinelli JuanLiu NinaHoffmann PascalLherbet ChristianTonge Peter J.Tekwani BabuMorbidoni Hector R.Labadie Guillermo R.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
21.Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR

机译：识别P218的有效抑制剂溃疡分枝杆菌DHFR
- 作者：Riboldi Gustavo P.;Zigweid Rachael;Myler Peter J.Mayclin Stephen J.Counago Rafael M.Staker Bart L.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
22.Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M-PRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model

机译：Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M-PRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model
- 作者：Franco Lucas S.;Maia Rodolfo C.;Barreiro Eliezer J.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- EMPIRICAL SCORING FUNCTIONS;
- DRUG DISCOVERY;
- CORONAVIRUS;
- SARS;
- SCAFFOLD;
- LIBRARY;
23.Structure-activity relationship studies on 2,5,6-trisubstituted benzimidazoles targeting Mtb-FtsZ as antitubercular agents

机译：结构与活性关系研究2、5、6-trisubstituted苯并咪唑的目标Mtb-FtsZ作为抗结核的代理商
- 作者：Haranahalli Krupanandan;Tong Simon;Kim SaeromAwwa MonafChen LeiKnudson Susan E.Slayden Richard A.Singleton EricRusso RiccardoConnell NancyOjima Iwao
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
24.Identification of LASSBio-1945 as an inhibitor of SARS-CoV-2 main protease (M-PRO) through in silico screening supported by molecular docking and a fragment-based pharmacophore model

机译：识别lassbio - 1945的抑制剂通过在SARS-CoV-2主要蛋白酶(M-PRO)支持的硅片筛选分子对接和fragment-based药效团模型
- 作者：Franco Lucas S.;Maia Rodolfo C.;Barreiro Eliezer J.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
25.Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?

机译：Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?
- 作者：Fullam Elizabeth;Young Robert J.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- CELL-WALL;
- TREHALOSE MONOMYCOLATE;
- NATURAL-PRODUCTS;
- IN-VITRO;
- DISCOVERY;
- MEMBRANE;
- TARGETS;
- DESIGN;
- POTENT;
- PERMEABILITY;
26.Medicinal chemistry updates on quinoline- and endoperoxide-based hybrids with potent antimalarial activity

机译：Medicinal chemistry updates on quinoline- and endoperoxide-based hybrids with potent antimalarial activity
- 作者：Uddin Amad;Chawla Meenal;Irfan IramMahajan ShubhraSingh ShailjaAbid Mohammad
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- PLASMODIUM-FALCIPARUM;
- BIOLOGICAL EVALUATION;
- IN-SILICO;
- ARTEMISININ;
- DRUG;
- DESIGN;
- MOLECULES;
- MALARIA;
- QUININE;
- CHLOROQUINE;
27.MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization (Retraction of Vol 9, Pg 1359, 2018)

机译：MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization (Retraction of Vol 9, Pg 1359, 2018)
- 作者：Lim Katie
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
28.Structure guided generation of thieno3,2-d pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors

机译：Structure guided generation of thieno3,2-d pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors
- 作者：Hopfner Sarah M.;Lee Bei Shi;Kalia Nitin P.Miller Marvin J.Pethe KevinMoraski Garrett C.
- 期刊名称：《RSC Medicinal Chemistry》 | 2021年第1期
- PERSISTENCE;
- Q203;

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