16.
Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7, 26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus Kinase 2/Fms-like tyrosine kinase-3 (JAK2/FLT3) inhibitor for the treatment of myelofibrosis and lymphoma
机译:发现大环化合物11-(2-吡咯烷-1-基-乙氧基)-14,19-dioxa-5,7,26-三氮杂-四环[19.3.1.1(2,6).1(8,12)] heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-十碳烯(SB1518),强力的Janus激酶2 / Fms样酪氨酸激酶3( JAK2 / FLT3)抑制剂,用于治疗骨髓纤维化和淋巴瘤