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Acta Pharmaceutica Sinica B

中文名称：Pharmaceutica学报B

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共25条结果

1.Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

机译：发现4-亚芳基噻吩-3-羧酸作为ANO1的抑制剂及其作为镇痛剂的作用
- 作者：Yuxi Wang;Jian Gao;Song Zhao;Yan Song;Han Huang;Guiwang Zhu;Peili Jiao;Xiangqing Xu;Guisen Zhang;Kewei Wang;Liangren Zhang;Zhenming Liu
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- ANO1 (anoctamin 1TMEM16A)InhibitorSynthesisStructure–activity relationshipAnalgesia;
2.Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy

机译：具有柔性DNA网络的涂层增强了T细胞活化和肿瘤杀死所采用的细胞疗法
- 作者：Ziyan Zhang;Qiaojuan Liu;Jizhou Tan;Xiaoxia Zhan;Ting Liu;Yuting Wang;Gen Lu;Minhao Wu;Yuanqing Zhang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Cell surface engineeringSelective cytoprotectionDNA nanostructureTetrahedral DNA nanostructureRolling circle amplificationAdoptive cell therapyT cellTumor-killing;
3.Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

机译：Lim激酶的抑制减少了膀胱平滑肌中的收缩和增殖
- 作者：Qingfeng Yu;Chengjie Wu;Yeda Chen;Bingsheng Li;Ruixiao Wang;Ru Huang;Xuechun Li;Di Gu;Xiaolong Wang;Xiaolu Duan;Shujue Li;Yang Liu;Wenqi Wu;Martin Hennenberg;Guohua Zeng
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- LIMKCofilin phosphorylationOveractive bladder (OAB)Lower urinary tract symptoms (LUTS)Bladder smooth muscle contraction4E-BP1 4E-binding protein 1ADF actin depolymerizing factorsBOO bladder outlet obstructionBPH benign prostatic hyperplasiaCCK-8 Cell Counting Kit-8Ct number of cyclesDMSO dimethyl sulfoxideEdU 5-ethynyl-2′-deoxyuridineGAPDH glyceraldehyde 3-phosphate dehydrogenaseHE hematoxylin and eosinHBSMCs human bladder smooth muscle cellsHRP horseradish peroxidaseLIMKs LIM kinasesLUTS lower urinary tract symptomsMLC myosin light chainMW molecular weightMYPT1 myosin-binding subunitOAB overactive bladderPCNA proliferating cell nuclear antigenRT-qPCR reverse transcription and quantitative polymerase chain reactionsiRNA small interfering RNASTK16 serine/threonine kinase 16TESK1 testicular protein kinase 1TXA2 thromboxane A2WST-8 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(24-disulfophenyl)-2 H -tetrazolium monosodium salt;
4.AncPhore: A versatile tool for anchor pharmacophore steered drug discovery with applications in discovery of new inhibitors targeting metallo-β-lactamases and indoleamine/tryptophan 2,3-dioxygenases

机译：ANCPHORE：用于锚定药物的多功能工具，用于发现靶向金属-β-内酰胺酶的新抑制剂和吲哚胺/色氨酸2,3-二氧化酶的新抑制剂中的应用
- 作者：Qingqing Dai;Yuhang Yan;Xiangli Ning;Gen Li;Junlin Yu;Ji Deng;Lingling Yang;Guo-Bo Li
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Anchor pharmacophoreMetalloenzymeVirtual screeningMetallo- β -lactamaseIndoleamine 23-dioxygenaseTryptophan 23-dioxygenaseAMPC asian mouse phenotyping consortiumAP anchor pharmacophoreAR aromatic ringAUC area under the curveBACE1 beta-secretase 1BRD4 bromodomain-containing protein 4CA carbonic anhydraseCA2 carbonic anhydrase 2CatK cathepsin KCDK2 cyclin-dependent kinase 2CTS cathepsinsCV covalent bondingEF enrichment factorEX exclusion volumeGA genetic algorithmHA hydrogen-bond acceptorHD hydrogen-bond donorHIV-P human immunodeficiency virus proteaseHIV1-P human immunodeficiency virus type 1 proteaseHY hydrophobicIDO1 indoleamine 23-dioxygenase 1IMP imipenemaseLE ligand efficiencyMAPK14 mitogen-activated protein kinase 14MB metal coordinationMBL metallo- β -lactamaseMIC minimum inhibitory concentrationMMP matrix metalloproteinaseMMP13 matrix metallopeptidase 13NDM new delhi MBLNE negatively charged centerNP without anchor pharmacophore featuresPO positively charged centerRMSD root mean square deviationROC curve receiver operating characteristic curveROCK1 rho-associated protein kinase 1RT reverse transcriptaseRTK receptor tyrosine kinaseSBL serine beta lactamaseSSEL secondary structure element lengthSTK serine threonine kinaseTDO tryptophan 23-dioxygenaseTDSS torsion-driving systematic searchTNKS2 tankyrase 2VEGFR2 vascular endothelial growth factor receptor 2VIM verona integron-encoded MBL;
5.Ginsenosides in Panax genus and their biosynthesis

机译：人参皂苷在Panax属及其生物合成中
- 作者：Maoqi Hou;Rufeng Wang;Shujuan Zhao;Zhengtao Wang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- GinsenosidePanax speciesBiosynthetic pathwayTranscription factorsNon-coding RNAsBiotechnological approachα -AS α -amyrin synthaseABA abscisic acidADP adenosine diphosphateAtCPR (ATR) Arabidopsis thaliana cytochrome P450 reductaseBARS baruol synthaseβ -AS β -amyrin synthaseCAS cycloartenol synthaseCDP cytidine diphosphateCPQ cucurbitadienol synthaseCYP cytochrome P450DDS dammarenediol synthaseDM dammarenediol-IIDMAPP dimethylallyl diphosphateFPP farnesyl pyrophosphateFPPS (FPS) farnesyl diphosphate synthaseGDP guanosine diphosphateHEJA 2-hydroxyethyl jasmonateHMGR HMG-CoA reductaseIPP isopentenyl diphosphateITS internal transcribed spacerJA jasmonic acidJA-Ile ( )-7- iso -jasmonoyl- l -isoleucineJAR JA-amino acid synthetaseJAZ jasmonate ZIM-domainKcMS Kandelia candel multifunctional triterpene synthasesLAS lanosterol synthaseLUP lupeol synthaseMEP methylerythritol phosphateMeJA methyl jasmonateMVA mevalonateMVD mevalonate diphosphate decarboxylaseNDP nucleotide diphosphateOA oleanane or oleanic acidOAS oleanolic acid synthaseOCT ocotillolOSC oxidosqualene cyclasePPD protopanaxadiolPPDS PPD synthasePPT protopanaxatriolPPTS PPT synthaseRNAi RNA interferenceSA salicylic acidSE (SQE) squalene epoxidaseSS (SQS) squalene synthaseSPL squamosa promoter-binding protein-likeSUS sucrose synthaseTDP thymine diphosphateUDP uridine diphosphateUGPase UDP-glucose pyrophosphosphprylaseUGT UDP-dependent glycosyltransferaseWGD whole genome duplication;
6.Enzyme-instructed hybrid nanogel/nanofiber oligopeptide hydrogel for localized protein delivery

机译：用于局部蛋白质递送的酶指示杂交纳米凝胶/纳米纤维寡肽水凝胶
- 作者：Tianyue Jiang;Yudi Ma;Xiao Xu;Qingchun Ji;Mingxing Feng;Cheng Cheng;Yang Feng;Bingfang He;Ran Mo
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Protein deliveryOligopeptide hydrogelNanogelEnzymatic catalysisCytochrome cApoptosisLocal administrationCancer therapy;
7.The influence of the gut microbiota on the bioavailability of oral drugs

机译：肠道微生物对口腔药物生物利用度的影响
- 作者：Xintong Zhang;Ying Han;Wei Huang;Mingji Jin;Zhonggao Gao
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Gut microbiotaOral drugsBioavailabilityProbioticsColon-specific drug delivery system5-ASA 5-aminosalicylic acidAA ascorbic acidABC ATP-binding cassetteACS amphipathic chitosan derivativeAMI amiodaronean OTC drug an over-the-counter drugAQP4 aquaporin 4AR azoreductaseASP amisulprideBBR berberineBCRP breast cancer resistance proteinBCS biopharmaceutics classification systemBDDCS the biopharmaceutics drug disposition classification systemBDEPT the bacteria-directed enzyme prodrug therapyBSH bile salt hydrolaseCA cholic acidCDCA chenodeoxycholic acidcgr operon cardiac glycoside reductase operonCPP cell-penetrating peptideCS chitosanDCA deoxycholic aciddhBBR dihydroberberineDRPs digoxin reduction productsEcN Escherichia coli Nissle 1917FA folateFAO Food and Agriculture Organization of the United NationsGCDC glycochenodeoxycholateGL glycyrrhizic acidHFD high fat dietHTC hematocritIBD inflammatory bowel diseaseLCA lithocholic acidLPS lipopolysaccharideMATEs multidrug and toxin extrusion proteinsMDR1 multidrug resistance gene 1MDR1a multidrug resistance protein-1aMKC monoketocholic acidMPA mycophenolic acidMRP2 multidrug resistance-associated protein 2NaDC sodium deoxycholateNaGC sodium glycholateNEC necrotizing enterocolitisNMEs new molecular entitiesNRs nitroreductasesNSAIDs non-steroidal anti-inflammatory drugsOATs organic anion transportersOCTNs organic zwitterion/cationOCTs organic cation transportersPD Parkinson's diseaseP-gp P-glycoproteinp K a dissociation constantPPIs proton pump inhibitorsPT pectinPWSDs poorly water-soluble drugsRA rheumatoid arthritisRBC red blood cellSCFAs short-chain fatty acidsSGLT-1 sodium-coupled glucose transporter 1SLC solute carrierSLN solid lipid nanoparticleSP sulfapyridineSSZ sulfasalazineSVCT-1/2 the sodium-dependent vitamin C transporter-1/2T1D type 1 diabetesT1DM type 1 diabetes mellitusT2D type 2 diabetesTCA taurocholateTCDC taurochenodeoxycholateTDCA taurodeoxycholatethe GI tract the gastrointestinal tractTLCA taurolithocholateTME the tumor microenvironmentUDC ursodeoxycholic acidWHO World Health Organization;
8.Protective effects of VMY-2-95 on corticosterone-induced injuries in mice and cellular models

机译：VMY-2-95对小鼠皮质酮诱导伤害的保护作用
- 作者：Ziru Yu;Dewen Kong;Yu Liang;Xiaoyue Zhao;Guanhua Du
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- α 4 β 2 nAChR antagonistVMY-2-95Cholinergic–adrenergic theoryDepressionCorticosteroneSH-SY5Y cellsPKA-CREB-BDNF signaling pathway;
9.Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence

机译：介导的金纳米杆介导的高效协同免疫疗法，用于检测和抑制术后肿瘤复发
- 作者：Yingying Zhang;Tiange Wang;Yu Tian;Chaonan Zhang;Kun Ge;Jinchao Zhang;Jin Chang;Hanjie Wang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Synergistic immunotherapyPost-surgical tumor recurrenceTheranosticsGold nanorodsPhototherapyLung metastasisFluorescence resonance energy transferCarcinoembryonic antigenAFP alpha fetoproteinanti-PDL1 anti-programmed cell death-ligand 1aPDL1-LA anti-PDL1-modified liposomes encapsulated AuNRsaPDL1-LA NIR anti-PDL1-modified liposomes encapsulated AuNRs with near-infrared irradiationaPDL1-LAI anti-PDL1-modified liposomes loaded with ICG and encapsulated AuNRsAP1-QDs CEA aptamer-modified CdTe QDsAP2-AuNRs CEA aptamer-modified AuNRsCdCl 2 cadmium chlorideCA cancer antigenCEA carcinoembryonic antigenCdTe QDs CdTe quantum dotsCTAB cetrimonium bromideCTCs circulating tumor cellsDC dendritic cellsDLS dynamic light scatteringEDC 1-ethyl-3-(3′-dimethylaminopropyl) carbodiimideFBS fetal bovine serumFRET fluorescence resonance energy transferGSH glutathioneAuNRs gold nanorodsHAuCl 4 gold chlorideHelf human embryonic lung fibroblasts linesHydrogel IFN- γ thermal responsive hydrogels loaded with interferon- γHydrogel IFN- γ QA thermal responsive hydrogels co-loaded with AP1-QDsAP2-AuNRs and interferon- γICG indocyanine greenIFN- γ interferon- γIR infraredLA liposomes encapsulated AuNRsLA NIR liposomes encapsulated AuNRs with near-infrared irradiationLAI liposomes loaded with ICG and encapsulated AuNRsLLC murine lung cancer cellsMTT 3-(45-dimethylthiazol-2-yl)-25-diphenyltetrazolium bromideNaBH 4 sodium borohydrideNaHTe sodium hydrogen tellurideNHS N -hydroxysuccinimideNIR near-infrared irradiationPD1 programmed cell death protein 1PDL1 programmed cell death-ligand 1PI propidium iodidePLGA-PEG-PLGA thermal responsive hydrogelPTT photothermal therapyQDs quantum dotsAgNO 3 silver nitrateTEM transmission electron microscope;
10.Natural compounds modulate the autophagy with potential implication of stroke

机译：天然化合物调节自噬具有中风的潜在含义
- 作者：Anil Ahsan;Mengru Liu;Yanrong Zheng;Wenping Yan;Lin Pan;Yue Li;Shijia Ma;Xingxian Zhang;Ming Cao;Zhanxun Wu;Weiwei Hu;Zhong Chen;Xiangnan Zhang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- AutophagyCerebral ischemiaNeuroprotectionMitochondriaLysosomal activationMitophagyNatural compoundsNeurological disordersAD Alzheimer's diseaseALS amyotrophic lateral sclerosisAMPK 5′-adenosine monophosphate-activated protein kinaseATF6 activating transcription factor 6ATG autophagy related genesBCL-2 B-cell lymphoma 2BNIP3L BCL2/adenovirusCOPII coat protein complex IIER endoplasmic reticulumeIF2a eukaryotic translation-initiation factor 2FOXO forkhead box OFUNDC1 FUN14 domain containing 1GPCR G-protein coupled receptorHD Huntington's diseaseIRE1 inositol-requiring enzyme 1IPC ischemic preconditioningJNK c-Jun N-terminal kinaseLAMP lysosomal-associated membrane proteinLC3 light chain 3LKB1 liver kinase B1mTOR mechanistic target of rapamycinΔ Ψ m mitochondrial membrane potentialTIGAR TP53-induced glycolysis and apoptosis regulatorPD Parkinson's diseasePERK protein kinase R (PKR)-like endoplasmic reticulum kinasePI3K phosphatidylinositol 3-kinaseOGD/R oxygen and glucose deprivation-reperfusionROS reactive oxygen speciesSQSTM1 sequestosome 1TFEB transcription factor EBULK Unc-51- like kinaseUro-A urolithin A;
11.Pure redox-sensitive paclitaxel–maleimide prodrug nanoparticles: Endogenous albumin-induced size switching and improved antitumor efficiency

机译：纯氧化还原紫杉醇 - 马来酰亚胺前药纳米粒子：内源白蛋白诱导的尺寸切换和改进的抗肿瘤效率
- 作者：Xinyu Lou;Dong Zhang;Hao Ling;Zhonggui He;Jin Sun;Mengchi Sun;Dongchun Liu
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- PaclitaxelAbraxaneRedox-sensitiveDisulfide bondMaleimideProdrug-based nano-drug delivery systemsProdrug/albumin nanoaggregatesBreast cancer treatment;
12.Synergetic delivery of triptolide and Ce6 with light-activatable liposomes for efficient hepatocellular carcinoma therapy

机译：具有可光活化的脂质体的晶晶和CE6的协同递送，用于有效的肝细胞癌治疗
- 作者：Ling Yu;Zhenjie Wang;Zhuomao Mo;Binhua Zou;Yuanyuan Yang;Rui Sun;Wen Ma;Meng Yu;Shijun Zhang;Zhiqiang Yu
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Hepatocellular carcinomaSynergetic deliveryTriptolideCe6Photo-activatable liposomesPhotosensitizerProcess of photodynamic therapyPDX modelALT liver-related alanine aminotransferaseAST aspartate aminotransferaseBCA bicinchoninic acidBUN blood urea nitrogenChol cholesterolCK creatine kinaseCK-MB creatine kinase-MBCLSM confocal laser scanning microscopyCr creatinineDEE drug encapsulation efficiencyDLC drug loading contentDLS dynamic light scatteringDox doxorubicinDSPG distearoyl phosphatidylglyceroleEPR enhanced permeability and retentionFBS fetal bovine serumFCM flow cytometryHCC hepatocellular carcinomaLDH lactate dehydrogenaseLP liposomesNIR near-infraredPDT photodynamic therapyPDX patient-derived xenograftPDXHCC patient derived tumor xenograft of HCCPI propidium iodidePt platinumROS reactive oxygen speciesSo sorafenibTEM transmission electron microscopeTP triptolideTP/Ce6-LP liposomes integrated with both photosensitizer Ce6 and chemotherapeutic drug TPTUNEL dT-mediated dUTP Nick-End Labeling;
13.Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats

机译：CP-25对GRK2激酶结构域的靶向抑制逆转成纤维细胞样Synoviocytes功能障碍，并改善大鼠胶原诱导的关节炎
- 作者：Chenchen Han;Yifan Li;Yuwen Zhang;Yang Wang;Dongqian Cui;Tingting Luo;Yu Zhang;Qian Liu;Hao Li;Chun Wang;Dexiang Xu;Yang Ma;Wei Wei
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- CP-25Rheumatoid arthritisFibroblast-like synoviocyteMH7AG protein coupled receptor kinase 2Prostaglandin E4 receptor;
14.3D organoids derived from the small intestine: An emerging tool for drug transport research

机译：来自小肠的3D有机剂：用于药物运输研究的新兴工具
- 作者：Yuanjin Zhang;Shengbo Huang;Weiguo Zhong;Wenxia Chen;Bingyi Yao;Xin Wang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- 3D organoidSmall intestineDrug transporterCaco-2 cell monolayerP-glycoproteinASCs adult somatic stem cellsBCRP breast cancer resistance proteinBMP bone morphogenetic proteinCDF 5(6)-carboxy-2′7′-dichlorofluoresceincMOAT canalicular multispecific organic anion transporterDDI drug–drug interactionsEGF epidermal growth factorER efflux ratioESCs embryonic stem cellsFGF fibroblast growth factoriPSCs induced pluripotent stem cellsLgr5 leucine-rich-repeat-containing G-protein-coupled receptor 5 positiveMCT monocarboxylate transporter proteinMRP2 multidrug resistance protein 2NBD nucleotide-binding domainOATP organic anion transporting polypeptideOCT organic cation transporterOCTN carnitine/organic cation transporterP app apparent permeability coefficientPEPT peptide transporter proteinP-gp P-glycoproteinPMAT plasma membrane monoamine transporterPSCs pluripotent stem cellsRh123 rhodamine 123SLC solute carrierTEER transepithelial electrical resistanceTMDs transmembrane domains;
15.Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

机译：鼻内温度敏感水凝胶包装复合物用于治疗后创伤后应激障碍
- 作者：Lulu Pang;Siqing Zhu;Jinqiu Ma;Lin Zhu;Yijing Liu;Ge Ou;Ruiteng Li;Yaxin Wang;Yi Liang;Xu Jin;Lina Du;Yiguang Jin
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Post-traumatic stress disorderCannabidiolHydroxypropyl- β -cyclodextrinInclusion complexHydrogelsBrain targetingBlood?brain barrierIntranasal administrationAUC area under the curveBBB blood?brain barrierCBD TSGs cannabidiol inclusion complex temperature-sensitive hydrogelsCNS central nervous systemCOVID-19 coronavirus disease 2019DSC differential scanning calorimetryHP- β -CD hydroxypropyl- β -cyclodextrinIR infraredIS internal standardMRM multiple reaction monitoringPPV percentage of persistent vibrationPTSD post-traumatic stress disorderPVD persistent vibration durationSSRIs selective serotonin reuptake inhibitorsTNF- α tumor necrosis factor- αWB Western blot;
16.Recent advances in nanomedicines for the treatment of ischemic stroke

机译：纳米胺的最新进展用于治疗缺血性卒中
- 作者：Chao Li;Tao Sun;Chen Jiang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- StrokeIschemic cascadeReperfusionNeuroprotectantThrombolyticsNanomedicineBlood?brain barrierAEPO asialo-erythropoietinAPOE apolipoprotein EBBB blood?brain barrierBCECs brain capillary endothelial cellsCAT catalaseCe-NPs ceria nanoparticlesCOX-1 cyclooxygenase-1cRGD cyclic Arg-Gly-AspCsA cyclosporine ACXCR-4 C-X-C chemokine receptor type 4DAMPs damage-associated molecular patternse-PAM-R arginine-poly-amidoamine esterGFs growth factorsGPIIb/IIIa glycoprotein IIb/IIIaHb hemoglobinHMGB1 high mobility group protein B1ICAM-1 intercellular adhesion molecule-1IL-1 β interleukin-1 βIL-6 interleukin-6iNOS inducible nitric oxide synthaseLFA-1 lymphocyte function-associated antigen-1LHb liposomal HbMCAO middle cerebral artery occlusionmiRNAs microRNAsMMPs matrix metalloproteinasesMSC mesenchymal stem cellNF- κ B nuclear factor- κ BNGF nerve growth factorNMDAR N -methyl- d -aspartate receptornNOS neuron nitric oxide synthaseNOS nitric oxide synthaseNPs nanoparticlesNSCs neural stem cellsPBCA poly-butylcyanoacrylatePCMS poly (chloromethylstyrene)PEG poly-ethylene-glycolPEG-PLA poly (ethylene-glycol)- b -poly (lactide)PLGA NPs poly ( l -lactide- co -glycolide) nanoparticlesPSD-95 postsynaptic density protein-95PSGL-1 P-selectin glycoprotein ligand-1RBCs red blood cellsRES reticuloendothelial systemRGD Arg-Gly-AspROS reactive oxygen speciesSDF-1 stromal cell-derived factor-1SHp stroke homing peptidesiRNA small interfering RNASOD superoxide dismutaseSUR1-TRPM4 sulfonylurea receptor 1-transient receptor potential melastatin-4TEMPO 2266-tetramethylpiperidine-1-oxylTIA transient ischemic attackTNF- α tumor necrosis factor- α;
17.Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in?vitro and in?vivo

机译：聚氧氨酸作为安全，有效和特异性的ABCB1抑制剂，以克服癌症化疗中的多药耐药性的体外和βvivo
- 作者：Xu Wu;Chun Yin;Jiang Ma;Stella Chai;Chunyuan Zhang;Sheng Yao;Onat Kadioglu;Thomas Efferth;Yang Ye;Kenneth Kin-Wah To;Ge Lin
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Multidrug resistanceABCB1PolyoxypregnaneCombination chemotherapyMarsdenia tenacissimaABC ATP-binding cassetteABCB1 ATP binding cassette subfamily B member 1ABCC1 ATP binding cassette subfamily C member 1ABCG2 ATP binding cassette subfamily G member 2ATF3 activating transcription factor 3AUC 0–∞ area under plasma concentration vs. time curveBBB blood–brain barrierBHI brain heart infusionCL clearanceC max peak concentrationCYP cytochrome P450 isozymeDox doxorubicinECL electrochemiluminescenceEVOM epithelial tissue voltohmmeterF bioavailabilityFBS fetal bovine serumGAPDH glyceraldehyde-3-phosphate dehydrogenaseHBSS Hank?s balanced salt solutionHE hematoxylin and eosinIC 50 half maximal inhibitory concentrationLBE lowest binding energyLC–MS liquid chromatography coupled with mass spectrometryM. tenacissima Marsdenia tenacissimaMDR multidrug resistanceMDR1a multidrug resistance protein 1aMRT mean residence timeNADPH reduced nicotinamide adenine dinucleotide phosphateN.A. not applicableN.D. not detectedNMPA National Medical Products AdministrationP app apparent permeabilityPBS phosphate buffer salinePCR polymerase chain reactionPE phycoerythrinPI propidium iodidePOP polyoxypregnanePXR pregnane X receptorqPCR quantitative PCRSD standard derivationSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresist 1/2 elimination half-lifeTEER transepithelial electrical resistanceT max time for peak concentrationUIC-2 mouse monoclonal ABCB1 antibodyV d volume of distribution;
18.Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

机译：具有治疗性适体的分子工程截短的组织因子，用于肿瘤靶向递送和血管梗塞
- 作者：Bozhao Li;Jingyan Wei;Chunzhi Di;Zefang Lu;Feilong Qi;Yinlong Zhang;Wei Sun Leong;Lele Li;Guangjun Nie;Suping Li
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Tumor targeted deliveryTruncated tissue factor (tTF)AS1411 aptamerThrombosisTumor infarction;
19.Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

机译：药理学靶向分子电机促进抗癌的线粒体裂变
- 作者：Yi Qian;Meimei Zhao;Qinghua Han;Jingkang Wang;Lixi Liao;Heng Yang;Dan Liu;Pengfei Tu;Hong Liang;Kewu Zeng
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Anti-cancerLiver hepatocellular carcinomaMitochondrial fissionSmall moleculeTarget identificationMolecular motorMYH9HSPA9CAM chick embryo chorioallantoic membraneCETSA cellular thermal shift assayCo-IP co-immunoprecipitationDAPI 4′6-diamidino-2-phenylindoleER endoplasmic reticulumHE hematoxylin–eosin stainingHSPA9 heat-shock protein A9HUVEC human umbilical vein endothelial cellsIHC immunohistochemistryLIHC liver hepatocellular carcinomaMMP mitochondrial membrane potentialMYH9 myosin-9SILAC stable isotope labeling with amino acids in cell cultureSPR surface plasmon resonanceTUNEL terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling;
20.Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects

机译：癌症干细胞靶向嵌合抗原受体（汽车）-T细胞疗法：挑战和前景
- 作者：Javad Masoumi;Abdollah Jafarzadeh;Jalal Abdolalizadeh;Haroon Khan;Jeandet Philippe;Hamed Mirzaei;Hamid Reza Mirzaei
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Chimeric antigen receptor T cellCancer stem cellImmunotherapyTumor associated antigensCombination therapyOff-tumor toxicityClinical trialTumor immunosuppressive microenvironment;
21.A novel PGAM5 inhibitor LFHP-1c protects blood–brain barrier integrity in ischemic stroke

机译：一种新的PGAM5抑制剂LFHP-1C保护缺血性卒中中的血脑屏障完整性
- 作者：Chenglong Gao;Yazhou Xu;Zhuangzhuang Liang;Yunjie Wang;Qinghong Shang;Shengbin Zhang;Cunfang Wang;Mingmin Ni;Dalei Wu;Zhangjian Huang;Tao Pang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Ischemic strokeBlood–brain barrierBrain microvascular endothelial cellsTarget identificationSurface plasmon resonancePGAM5NRF2LFHP-1c;
22.The chromosome-level reference genome assembly for Dendrobium officinale and its utility of functional genomics research and molecular breeding study

机译：石斛型染色体参考基因组组装及其功能基因组学研究与分子育种研究的效用
- 作者：Zhitao Niu;Fei Zhu;Yajuan Fan;Chao Li;Benhou Zhang;Shuying Zhu;Zhenyu Hou;Mengting Wang;Jiapeng Yang;Qingyun Xue;Wei Liu;Xiaoyu Ding
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Dendrobium officinaleGenomeActive ingredientsGWASPlant production;
23.In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organic framework nanoparticles

机译：原位触发醇滥用药物二呋盐抗肿瘤效果通过Cu基金属 - 有机骨架纳米颗粒
- 作者：Lin Hou;Yanlong Liu;Wei Liu;Mervat Balash;Hongling Zhang;Yi Zhang;Huijuan Zhang;Zhenzhong Zhang
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- DisulfiramCopperMetal-organic frameworkHyaluronic acidLysosomal escapeDSF/Cu complexIn situAntitumor therapy;
24.The cellular immunotherapy of integrated photothermal anti-oxidation Pd–Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis

机译：集成光热抗氧化PD-SE纳米颗粒的细胞免疫疗法抑制类风湿性关节炎巨噬细胞炎症反应的抑制作用
- 作者：Chuping Zheng;Aiping Wu;Xinyun Zhai;Hong Ji;Zhikang Chen;Xu Chen;Xiyong Yu
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- Rheumatoid arthritisInflammatory responsePhotothermal therapyAnti-oxidation therapyCore?shell structure;
25.The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review

机译：Phytoecdysteroids的植物化学，生物学和药用属性：更新的审查
- 作者：Niranjan Das;Siddhartha Kumar Mishra;Anusha Bishayee;Eunüs S. Ali;Anupam Bishayee
- 期刊名称：《Acta Pharmaceutica Sinica B》 | 2021年第7期
- PhytoecdysteroidsSecondary metabolitesAntioxidantAnti-inflammatoryAntimicrobialAntidiabeticAnticancer activity;

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