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Current drug targets. Immune, endocrine and metabolic disorders

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中文名称：当前的药物靶点。代谢紊乱

ISSN：1568-0088
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发文量：110

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1.Targeting the Nef induced increase of HIV infectivity.

机译：靶向Nef导致HIV感染力增加。
- 作者：Federico M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- pathogenicity;
- Therapeutic;
- HIV;
- Attack;
- basic research;
2.Controlling HIV-1 Rev function.

机译：控制HIV-1 Rev功能。
- 作者：Cochrane A
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- physiological aspects;
- HIV-1;
- Infection as complication of medical care;
3.Redifferentiation therapy in advanced thyroid cancer.

机译：晚期甲状腺癌的再分化治疗。
- 作者：Haugen BR
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- Thyroid Cancer;
- Therapeutic procedure;
- Iodine;
- Histones;
- depsipeptide;
- 碘;
- 组蛋白类;
4.HDL and Inflammation in Atherosclerosis.

机译：HDL和动脉粥样硬化发炎。
- 作者：Spieker LE;Ruschitzka F;Luscher TF;Noll G
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第1期
- High density lipoprotein measurement;
- Therapeutic;
- Vascular Diseases;
- Inflammation;
- 血管疾病;
- 炎症;
- 胆固醇;
5.Recent advances in the understanding of HIV-1 Vpu accessory protein functions.

机译：对HIV-1 Vpu辅助蛋白功能的了解的最新进展。
- 作者：Binette J;Cohen EA
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- HIV-1;
- proteins by function;
- Comprehension;
- Proteins;
- 蛋白质类;
6.Viral mediated gene therapy for the management of metastatic thyroid carcinoma.

机译：病毒介导的基因疗法可治疗转移性甲状腺癌。
- 作者：DeGroot LJ;Zhang R
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- Neoplasms;
- Desiccated thyroid;
- Gene Therapy;
- Interleukin-12;
- 肿瘤;
- 基因疗法;
- 白细胞介素12;
7.Common and uncommon features of rheumatoid arthritis and chronic obstructive pulmonary disease: clues to a future therapy.

机译：类风湿关节炎和慢性阻塞性肺疾病的常见和罕见特征：未来治疗的线索。
- 作者：Andreakos E
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第2期
- Rheumatoid Arthritis;
- Therapeutic procedure;
- Chronic Obstructive Airway Disease;
8.The pathobiology of osteoarthritis and the rationale for using the chondroitin sulfate for its treatment.

机译：骨关节炎的病理生物学和使用硫酸软骨素进行治疗的基本原理。
- 作者：Volpi N
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第2期
- Osteoarthritis;
- Slow;
- therapeutic aspects;
- Chondroitin Sulfates;
- Cesium;
- 骨关节炎;
- 软骨素硫酸盐类;
- 铯;
9.The sodium-iodide symporter.

机译：碘化钠同向转运蛋白。
- 作者：Baker CH;Morris JC
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- sodium-iodide symporter;
- Thyroid Gland;
- therapeutic aspects;
- Diagnostic;
- 甲状腺;
10.Targeting the ERK pathway: novel therapeutics for thyroid cancer.

机译：针对ERK途径：甲状腺癌的新疗法。
- 作者：Williams SF;Smallridge RC
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- Thyroid Cancer;
- novel;
- Oncogene;
- RET;
- inhibitors;
11.Functions of the HIV-1 Nef protein.

机译：HIV-1 Nef蛋白的功能。
- 作者：Baur A
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- Proteins;
- Functions;
- HIV-1;
- overview;
- 蛋白质类;
12.Treatment of inflammatory and paraproteinemic neuropathies.

机译：炎性和副蛋白神经病的治疗。
- 作者：Monaco S;Turri E;Zanusso G;Maistrello B
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第2期
- therapeutic aspects;
- cisplatin/etoposide protocol;
- Progression;
- Peripheral neuropathy;
13.CD26/Dipeptidyl Peptidase IV: A Regulator of Immune Function and a Potential Molecular Target for Therapy.

机译：CD26 /二肽基肽酶IV：免疫功能的调节剂和治疗的潜在分子靶标。
- 作者：Aytac U;Dang NH
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第1期
- Antigens;
- CD26;
- dipeptidylpeptidase IV;
- Role;
- Molecule;
- Function;
- 抗原;
- CD26;
- 角色;
14.Activins, myostatin and related tgf-Beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders.

机译：激活素，肌生长抑制素和相关的tgf-Beta家族成员是内分泌，代谢和免疫疾病的新型治疗靶标。
- 作者：Tsuchida K
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第2期
- Activins;
- myostatin;
- novel;
- growth aspects;
15.Molecular elements of apoptosis-regulating pathways in follicular thyroid cells: mining for novel therapeutic targets in the treatment of thyroid carcinoma.

机译：滤泡性甲状腺细胞中凋亡调节途径的分子元素：为甲状腺癌的治疗寻找新的治疗靶点。
- 作者：Sarlis NJ;Gourgiotis L
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- Apoptosis;
- Desiccated thyroid;
- therapeutic aspects;
- novel;
- Therapeutic;
- 脱噬作用;
16.Molecular basis of therapeutic strategies for breast cancer.

机译：乳腺癌治疗策略的分子基础。
- 作者：Huang J;Li X;Hilf R;Bambara RA;Muyan M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Breast Neoplasms;
- Estrogen Receptor alpha;
- Estrogen Receptor beta;
- Signal Transduction;
- 乳腺肿瘤;
- 信号传递;
17.Ion transport across the gallbladder epithelium.

机译：离子转运穿过胆囊上皮。
- 作者：Meyer G;Guizzardi F;Rodighiero S;Manfredi R;Saino S;Sironi C;Garavaglia ML;Bazzini C;Botta G;Portincasa P;Calamita G;Paulmichl M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Sodium measurement;
- Ions;
- Gallbladder;
- Process of secretion;
- apical membrane;
- 离子;
- 胆囊;
18.Therapeutic potential of glycolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases.

机译：糖脂配体在抑制自身免疫性疾病中对自然杀伤（NK）T细胞的治疗潜力。
- 作者：Miyake S;Yamamura T
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Autoimmune Diseases;
- Glycolipids;
- T-Lymphocytes;
- Laboratory mice;
- 自身免疫疾病;
- 糖脂类;
- T淋巴细胞;
19.Signaling mechanism for the insulin-like effects of growth hormone -- another example of a classical hormonal negative feedback loop.

机译：生长激素的胰岛素样作用的信号传导机制-经典激素负反馈回路的另一个例子。
- 作者：Ridderstrale M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- Insulin;
- Growth hormone measurement;
- JAK2;
- receptor;
- Proteins;
- 胰岛素;
- 蛋白质类;
20.Effects of fatty acid bile acid conjugates (FABACs) on biliary lithogenesis: Ppotential consequences for non-surgical treatment of gallstones.

机译：脂肪酸胆汁酸结合物（FABACs）对胆道结石的影响：胆囊结石非手术治疗的潜在后果。
- 作者：Konikoff FM;Gilat T
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Cholesterol;
- Gallstones;
- Bile Acids;
- Biliary;
- Fatty Acids;
- 胆固醇;
- 脂肪酸类;
21.Pharmacological manipulation of biliary water and lipids: potential consequences for prevention of acute biliary pancreatitis.

机译：胆汁水和脂质的药理处理：预防急性胆源性胰腺炎的潜在后果。
- 作者：Venneman NG;vanBerge Henegouwen GP;van Erpecum KJ
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Biliary;
- Pancreatitis;
- Acute;
- Cholesterol;
- secondary prevention;
- 胰腺炎;
- 胆固醇;
22.Advances in osteoclast differentiation and function.

机译：破骨细胞分化和功能的研究进展。
- 作者：Abu Amer Y
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Osteoclasts;
- differentiation;
- Skeletal bone;
- physiological aspects;
- Therapeutic procedure;
- 破骨细胞;
23.The new immunosuppression: intervention at the dendritic cell-T-cell interface.

机译：新的免疫抑制：在树突状细胞-T细胞界面的干预。
- 作者：Paterson AM;Yates SF;Nolan KF;Waldmann H
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Antibodies;
- Monoclonal;
- Dendritic Cells;
- Immunosuppression;
- Immunosuppressive Agents;
- 抗体;
- 单克隆;
- 树突细胞;
- 免疫抑制;
- 免疫抑制剂;
- T淋巴细胞;
24.Effects of leptin on biliary lipids: potential consequences for gallstone formation and therapy in obesity.

机译：瘦素对胆脂的影响：胆结石形成和肥胖症治疗的潜在后果。
- 作者：Mendez Sanchez N;Ponciano Rodrigoez G;Chavez Tapia N;Uribe M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Gallstones;
- Obesity;
- Cholesterol;
- Biliary;
- Leptin;
- 肥胖症;
- 胆固醇;
25.From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy: a detective story.

机译：从疾病的分子足迹到糖尿病性肾病的新治疗手段：侦探故事。
- 作者：Miyata T;Kurokawa K;van Ypersele de Strihou C
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Proteins;
- Diabetic Nephropathies;
- Therapeutic;
- in vivo;
- Relationship by association;
- 蛋白质类;
- 糖尿病肾病;
26.CXCR3-binding chemokines: novel multifunctional therapeutic targets.

机译：CXCR3结合趋化因子：新型多功能治疗靶标。
- 作者：Lazzeri E;Romagnani P
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- receptor;
- novel;
- Therapeutic;
- binding;
27.Role of FXR in regulating bile acid homeostasis and relevance for human diseases.

机译：FXR在调节胆汁酸稳态和与人类疾病的相关性中的作用。
- 作者：Rizzo G;Renga B;Mencarelli A;Pellicciari R;Fiorucci S
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Bile Acids;
- Chenodeoxycholic Acid;
- activate;
- Homeostasis;
- 鹅脱氧胆酸;
- 体内稳态;
28.Regulation of the steroidogenic acute regulatory protein expression: functional and physiological consequences.

机译：类固醇生成的急性调节蛋白表达的调节：功能和生理后果。
- 作者：Manna PR;Stocco DM
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- steroidogenic acute regulatory protein;
- Regulation;
- endocrinologic;
- Hepatitis;
- Chronic Active;
- 肝炎;
- 慢性活动性;
29.Failure of immune homeostasis -- the consequences of under and over reactivity.

机译：免疫稳态的失败-反应过度和不足的后果。
- 作者：Crimeen Irwin B;Scalzo K;Gloster S;Mottram PL;Plebanski M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Autoimmune Diseases;
- Homeostasis;
- Immunotherapy;
- Neoplasms;
- Virus Diseases;
- 自身免疫疾病;
- 体内稳态;
- 免疫疗法;
- 肿瘤;
- 病毒性疾病;
30.Manipulation of biliary lipids by gene therapy: potential consequences for patients with progressive familial intrahepatic cholestasis.

机译：通过基因疗法操纵胆汁脂质：进行性家族性肝内胆汁淤积症患者的潜在后果。
- 作者：Oude Elferink RP
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Gene Therapy;
- Manipulation procedure;
- Biliary;
- Therapeutic procedure;
- therapeutic aspects;
- 基因疗法;
31.Functional foods: salient features and clinical applications.

机译：功能性食品：主要特征和临床应用。
- 作者：Riezzo G;Chiloiro M;Russo F
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Food;
- Clinical;
- Malignant Neoplasms;
- Functional;
- 食品;
32.Signal transduction by IL-2 and its receptors as target in treatment of rheumatoid arthritis.

机译：IL-2及其受体作为类风湿关节炎治疗靶标的信号转导。
- 作者：Kozanidou VI;Theocharis AD;Georgiadis A;Voulgari PV;Drosos AA;Karamanos NK
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- Interleukin-2;
- Rheumatoid Arthritis;
- receptor;
- Therapeutic;
- Cytokines;
- 白细胞介素2;
- 细胞活素类;
33.Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches.

机译：线粒体三功能蛋白缺陷：分子基础和新的治疗方法。
- 作者：Angdisen J;Moore VD;Cline JM;Payne RM;Ibdah JA
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- Proteins;
- defects;
- maltose tetrapalmitate;
- novel;
- Mitochondrial;
- 蛋白质类;
34.Boosting interleukin-10 production: therapeutic effects and mechanisms.

机译：促进白介素10的产生：治疗效果和机制。
- 作者：Zhou X;Schmidtke P;Zepp F;Meyer CU
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Autoimmune Diseases;
- Graft Rejection;
- Inflammation;
- Interleukin-10;
- 自身免疫疾病;
- 移植物排斥;
- 炎症;
- 白细胞介素10;
35.Modulation of cholesterol crystallization in bile. Implications for non-surgical treatment of cholesterol gallstone disease.

机译：胆汁中胆固醇结晶的调节。对胆固醇非结石病非手术治疗的意义。
- 作者：Portincasa P;Moschetta A;van Erpecum KJ;Vacca M;Petruzzelli M;Calamita G;Meyer G;Palasciano G
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Cholesterol;
- Bile;
- Precipitation;
- Gallstones;
- Crystallization;
- 胆固醇;
- 胆汁;
- 沉淀;
- 结晶;
36.Myocardial insulin resistance and cardiac complications of diabetes.

机译：心肌胰岛素抵抗和糖尿病的心脏并发症。
- 作者：Abel ED
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Cardio-;
- Insulin Resistance;
- Diabetes;
- Obesity;
- 胰岛素抗药性;
- 肥胖症;
37.Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes.

机译：减少肝葡萄糖生成作为糖尿病治疗中的治疗靶标。
- 作者：Wu C;Okar DA;Kang J;Lange AJ
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- Glucose;
- Hepatic;
- Production;
- Diabetes;
- enzymology;
- 葡萄糖;
38.The mammalian innate immune system: potential targets for drug development.

机译：哺乳动物先天免疫系统：药物开发的潜在目标。
- 作者：Wheeler TT;Hood KA
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Immune System;
- novel;
- Comprehension;
- Mammals;
- drug development;
- 免疫系统;
- 哺乳动物;
39.New approach to immunotherapy against organ-specific autoimmune diseases with T cell receptor and chemokine receptor DNA vaccines.

机译：用T细胞受体和趋化因子受体DNA疫苗针对器官特异性自身免疫疾病进行免疫疗法的新方法。
- 作者：Matsumoto Y
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- Organ;
- Receptors;
- Antigen;
- T-Cell;
- Autoimmune Diseases;
- Receptors;
- Chemokine;
- 受体;
- 抗原;
- T细胞;
- 自身免疫疾病;
- 受体;
- 趋化因子;
40.Hormonal effects on drug metabolism through the CYP system: perspectives on their potential significance in the era of pharmacogenomics.

机译：激素通过CYP系统对药物代谢的影响：关于它们在药物基因组学时代的潜在意义的观点。
- 作者：Sarlis NJ;Gourgiotis L
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Cytochrome P-450 Enzyme System;
- Hormones;
- Liver;
- 激素类;
- 肝;
41.Therapeutic targets for the prevention of type 1 diabetes mellitus.

机译：预防1型糖尿病的治疗目标。
- 作者：Singh N;Palmer JP
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Diabetes Mellitus;
- Insulin-Dependent;
- Prevention;
- Niacinamide;
- Therapeutic brand of coal tar;
- 糖尿病;
- 胰岛素依赖型;
- 烟酰胺;
42.Management of liver disease in thalassemia: main drug targets for a correct therapy.

机译：地中海贫血肝病的管理：正确治疗的主要药物靶点。
- 作者：Del Vecchio GC;Nigro A;Giordano P;De Mattia D
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Hepatitis;
- Viral;
- Human;
- Iron Overload;
- Thalassemia;
- 肝炎;
- 病毒性;
- 人;
- 铁超负荷;
- 贫血;
- 珠蛋白生成障碍性;
43.Therapeutic strategies to prevent neurodegeneration and promote regeneration in multiple sclerosis.

机译：预防神经变性并促进多发性硬化症再生的治疗策略。
- 作者：Chitnis T;Imitola J;Khoury SJ
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- Morphine Sulfate;
- Multiple Sclerosis;
- Nerve Degeneration;
- Central Nervous System;
- 多发性硬化;
- 神经变性;
- 中枢神经系统;
44.Hormonal contraception in men.

机译：男性激素避孕。
- 作者：Walton M;Anderson RA
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Contraception;
- Male gender;
- Male population group;
- Psychological suppression;
- 避孕;
45.Effects of endocrine disruptors on developmental and reproductive functions.

机译：内分泌干扰物对发育和生殖功能的影响。
- 作者：Brevini TA;Zanetto SB;Cillo F
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- FUNCTIONS OF REPRODUCTION;
- Polychlorinated Biphenyls;
- Hormones;
- Catabolism;
- 多氯联苯化合物;
- 激素类;
46.Determination of binding constant of DNA-binding drug to target DNA by surface plasmon resonance biosensor technology.

机译：通过表面等离振子共振生物传感器技术确定DNA结合药物与靶DNA的结合常数。
- 作者：Lin LP;Huang LS;Lin CW;Lee CK;Chen JL;Hsu SM;Lin S
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第1期
- DNA;
- binding;
- Biosensors;
- experiment;
- Surface Plasmon Resonance;
- 生物传感器;
- 表面等离激元;
47.Augmenting T helper cell immunity in cancer.

机译：增强癌症中的T辅助细胞免疫力。
- 作者：Knutson KL;Disis ML
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Cancer Vaccines;
- Neoplasms;
- T-Lymphocytes;
- Helper-Inducer;
- 癌症疫苗;
- 肿瘤;
- T淋巴细胞;
- 辅助诱导;
48.Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs.

机译：肿瘤神经内分泌垂体细胞中的信号传导过程可能成为治疗药物的靶标。
- 作者：Paez Pereda M;Giacomini D;Echenique C;Stalla GK;Holsboer F;Arzt E
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Therapeutic;
- control;
- Production;
- activate;
49.The genetic background of cholesterol gallstone formation: an inventory of human lithogenic genes.

机译：胆固醇胆结石形成的遗传背景：人类成石基因清单。
- 作者：Lammert F;Matern S
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Gallstones;
- Human;
- Genetic;
- Genes;
- Cholesterol;
- 基因;
- 胆固醇;
50.Water transport into bile and role in bile formation.

机译：水运入胆汁并在胆汁形成中起作用。
- 作者：Calamita G;Ferri D;Gena P;Liquori GE;Marinelli RA;Meyer G;Portincasa P;Svelto M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Bile;
- Water;
- Aquaporins;
- Process of secretion;
- 胆汁;
- 水;
- 水孔蛋白类;
51.Contribution of canalicular glutathione efflux to bile formation. From cholestasis associated alterations to pharmacological intervention to modify bile flow.

机译：小管谷胱甘肽外排对胆汁形成的贡献。从胆汁淤积相关改变到药理干预以改变胆汁流量。
- 作者：Grattagliano I;Portincasa P;Palmieri VO;Palasciano G
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Bile;
- Glutathione;
- Biliary;
- pharmacological;
- Hepatic;
- 胆汁;
- 谷胱甘肽;
52.Caspases as drug targets in ischemic organ injury.

机译：胱天蛋白酶作为缺血性器官损伤中的药物靶标。
- 作者：Faubel S;Edelstein CL
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Injury inflicted to the body by an external force;
- Psychological inhibition;
- 肾;
- 心脏;
53.Insulin regulation of PEPCK gene expression: a model for rapid and reversible modulation.

机译：PEPCK基因表达的胰岛素调节：快速和可逆调节的模型。
- 作者：Quinn PG;Yeagley D
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Gene Expression Regulation;
- Enzymologic;
- Insulin;
- Liver;
- Phosphoenolpyruvate Carboxykinase (GTP);
- 基因表达调控;
- 酶学;
- 胰岛素;
- 肝;
54.Assessment of modes of action and efficacy of plasma cholesterol-lowering drugs: measurement of cholesterol absorption, cholesterol synthesis and bile acid synthesis and turnover using novel stable isotope techniques.

机译：评估血浆降胆固醇药物的作用方式和功效：使用新型稳定同位素技术测量胆固醇吸收，胆固醇合成和胆汁酸合成及周转率。
- 作者：Stellaard F;Kuipers F
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Cholesterol;
- Bile Acids;
- absorption characteristics;
- Methodology;
- 胆固醇;
55.Amino Acid Transporter ATB0,+ as a delivery system for drugs and prodrugs.

机译：氨基酸转运蛋白ATB0 +作为药物和前药的递送系统。
- 作者：Ganapathy ME;Ganapathy V
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Amino Acid Transport System ASC;
- Drug Delivery Systems;
- Pharmaceutical Preparations;
- 药物投与系统;
- 药物前体;
56.Lipid transport into bile and role in bile formation.

机译：脂质转运入胆汁并在胆汁形成中起作用。
- 作者：Groen AK;Oude Elferink RP
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Lipids;
- Process of secretion;
- Bile Salts;
- Biliary;
- 脂类;
57.Estrogen receptor signalling: bases for drug actions.

机译：雌激素受体信号传导：药物作用的基础。
- 作者：Marino M;Acconcia F;Ascenzi P
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Estradiol;
- estrogen receptor beta;
- Estrogen Receptors;
- estrogen receptor alpha;
- 雌二醇;
58.Drugs affecting biliary lipid secretion and gallbladder motility: their potential role in gallstone treatment and prevention.

机译：影响胆汁脂质分泌和胆囊运动的药物：它们在胆结石治疗和预防中的潜在作用。
- 作者：vanBerge Henegouwen GP;Venneman NG;van Erpecum KJ;Portincasa P
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第2期
- Gallstones;
- motility;
- Gallbladder;
- Prevention;
- g lt;
- 3gt;
- 胆囊;
59.Drug targets in colonoscopic polypectomy: biological sealants with special reference to fibrin-glue (tissucol).

机译：结肠镜息肉切除术中的药物靶标：生物密封剂，特别提及纤维蛋白胶（tissucol）。
- 作者：Venezia P
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第3期
- Seals;
- Glues;
- Fibrin;
- Complications Specific to Antepartum or Postpartum;
- 海豹;
- 纤维蛋白;
60.Signal transducer and activator of transcription 5 (STAT5), a crucial regulator of immune and cancer cells.

机译：信号转导子和转录激活子5（STAT5），是免疫细胞和癌细胞的重要调节剂。
- 作者：Wittig I;Groner B
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2005年第4期
- Neoplasms;
- STAT5 Transcription Factor;
- T-Lymphocytes;
- 肿瘤;
- T淋巴细胞;
61.Vitamin D analogs--drug design based on proteins involved in vitamin D signal transduction.

机译：维生素D类似物-基于参与维生素D信号转导的蛋白质的药物设计。
- 作者：Masuda S;Jones G
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第1期
- Drug Design;
- Proteins;
- Signal Transduction;
- Vitamin D;
- 药物设计;
- 蛋白质类;
- 信号传递;
- 维生素D;
62.Surface-linked liposomal antigen induces IgE selective unresponsiveness in a T-cell independent fashion.

机译：表面连接的脂质体抗原以独立于T细胞的方式诱导IgE选择性无反应性。
- 作者：Uchida T
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第2期
- Antigens;
- Surface;
- Antigens;
- T-Independent;
- Immunoglobulin E;
- Liposomes;
- 抗原;
- 表面;
- 抗原;
- T细胞非依赖性;
- 脂质体;
63.Stearoyl-CoA desaturase-1 and the metabolic syndrome.

机译：硬脂酰辅酶A去饱和酶-1与代谢综合征。
- 作者：Cohen P;Ntambi JM;Friedman JM
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- Leptin;
- Obesity;
- Anemia;
- Sickle Cell;
- Syndrome;
- Joule;
- Unit of energy;
- 肥胖症;
- 贫血;
- 镰状细胞;
- 综合征;
64.Thalidomide derived immunomodulatory drugs (IMiDs) as potential therapeutic agents.

机译：沙利度胺衍生的免疫调节药物（IMiDs）作为潜在的治疗剂。
- 作者：Marriott JB;Dredge K;Dalgleish AG
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- Thalidomide;
- Clinical;
- novel;
- Therapeutic agent;
- NOS;
- development aspects;
- 沙立度胺;
65.WISH cells as a model for the 'in vitro' study of amnion pathophysiology.

机译：WISH细胞作为羊膜病理生理学“体外”研究的模型。
- 作者：Pavan B;Fiorini S;Ferretti ME;Vesce F;Biondi C
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第1期
- Amnion;
- Cell Line;
- 羊膜;
- 细胞系;
66.Unfolding the pathophysiological role of bioactive lysophospholipids.

机译：发挥生物活性溶血磷脂的病理生理作用。
- 作者：Xu Y;Xiao YJ;Zhu K;Baudhuin LM;Lu J;Hong G;Kim KS;Cristina KL;Song L;S Williams F;Elson P;Markman M;Belinson J
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第1期
- Lysophospholipids;
- Signal Transduction;
- 溶磷脂素类;
- 信号传递;
67.Breast cancer: biological characteristics in postmenopausal type 2 diabetic women. Identification of therapeutic targets.

机译：乳腺癌：绝经后2型糖尿病女性的生物学特征。鉴定治疗靶标。
- 作者：Guastamacchia E;Resta F;Mangia A;Schittulli F;Ciampolillo A;Triggiani V;Licchelli B;Paradiso A;Sabba C;Tafaro E
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- Human Females;
- Malignant neoplasm of breast;
- receptor;
- Therapeutic;
- Postmenopausal state;
68.Protein-tyrosine phosphatase 1B as a potential drug target for obesity.

机译：蛋白酪氨酸磷酸酶1B作为肥胖症的潜在药物靶标。
- 作者：Dadke S;Chernoff J
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- Obesity;
- 1B;
- Leptin;
- Insulin;
- Protein measurement;
- 肥胖症;
- 胰岛素;
69.Controlled modulation of inflammatory, stress and apoptotic responses in macrophages.

机译：巨噬细胞中炎症，应激和凋亡反应的受控调节。
- 作者：Malyshev IY;Shnyra A
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第1期
- Apoptosis;
- Inflammation Mediators;
- Macrophages;
- Stress;
- 脱噬作用;
- 炎症介导素类;
- 巨噬细胞;
- 应激;
70.Induction of optimal immune responses against human immunodeficiency virus at mucosal portals of entry.

机译：在进入的粘膜入口诱导针对人免疫缺陷病毒的最佳免疫反应。
- 作者：Vajdy M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- HIV;
- Systemic;
- Immune response;
- Immunization;
- 免疫法;
71.Metformin and its liver targets in the treatment of type 2 diabetes.

机译：二甲双胍及其肝脏靶向治疗2型糖尿病。
- 作者：Radziuk J;Bailey CJ;Wiernsperger NF;Yudkin JS
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第2期
- Diabetes Mellitus;
- Non-Insulin-Dependent;
- Drug Delivery Systems;
- Hypoglycemic Agents;
- 糖尿病;
- 非胰岛素依赖型;
- 药物投与系统;
- 降血糖药;
- 肝;
- 二甲双胍;
72.Skin photoprotection by green tea: antioxidant and immunomodulatory effects.

机译：绿茶对皮肤的光保护作用：抗氧化和免疫调节作用。
- 作者：Katiyar SK
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- GREEN TEA;
- Integumentary system;
- Guanosine Triphosphate;
- Human;
- 鸟苷三磷酸;
73.Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists.

机译：通过甲酰肽受体激动剂和拮抗剂研究人类嗜中性粒细胞的生物学功能。
- 作者：Dalpiaz A;Spisani S;Biondi C;Fabbri E;Nalli M;Ferretti ME
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第1期
- N-Formylmethionine Leucyl-Phenylalanine;
- Neutrophils;
- Receptors;
- Immunologic;
- N-甲酰甲硫氨酰亮氨酰苯丙氨酸;
- 中性白细胞;
- 受体;
- 免疫;
- 受体;
- 肽;
74.Biosynthetic pathways of plastid-derived organelles as potential drug targets against parasitic apicomplexa.

机译：质体细胞器的生物合成途径作为潜在的抗寄生虫复合体药物的靶标。
- 作者：Seeber F
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第2期
- Apicomplexa;
- Drug Delivery Systems;
- Organelles;
- Parasitic Diseases;
- Plastids;
- 顶复门;
- 药物投与系统;
- 细胞器;
- 寄生虫病;
- 质体;
75.Tissue-specific glucocorticoid reactivating enzyme, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) - a promising drug target for the treatment of metabolic syndrome.

机译：组织特异性糖皮质激素激活酶11β-羟类固醇脱氢酶1型（11beta-HSD1）-一种有望用于治疗代谢综合征的药物靶标。
- 作者：Masuzaki H;Flier JS
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- Glucocorticoids;
- 11beta-HSD1;
- Syndrome;
- Fatty acid glycerol esters;
- Obesity;
- 糖皮质激素类;
- 综合征;
- 肥胖症;
76.The evolving therapeutic approaches for Epstein-Barr virus infection in immunocompetent and immunocompromised individuals.

机译：在免疫能力强和免疫功能低下的个体中爱泼斯坦-巴尔病毒感染不断发展的治疗方法。
- 作者：Okano M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第2期
77.Pathobiology of cholesterol gallstone disease: from equilibrium ternary phase diagram to agents preventing cholesterol crystallization and stone formation.

机译：胆固醇胆结石疾病的病理生物学：从平衡三元相图到防止胆固醇结晶和结石形成的药物。
- 作者：Portincasa P;Moschetta A;Calamita G;Margari A;Palasciano G
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第1期
- Cholelithiasis;
- Cholesterol;
- 胆结石;
- 胆固醇;
78.Drug-induced aseptic meningitis.

机译：药物性无菌性脑膜炎。
- 作者：Nettis E;Calogiuri G;Colanardi MC;Ferrannini A;Tursi A
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第2期
- Meningitis;
- Aseptic;
- 脑膜炎;
- 无菌性;
79.Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?

机译：急性氰化物中毒的解毒剂对巯基丙酮酸硫转移酶有促进排毒作用吗？
- 作者：Nagahara N;Li Q;Sawada N
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- Cyanides;
- MST;
- Detoxification procedure;
- Sulfurtransferases;
- Acute;
- 氰化物;
- 硫基转移酶类;
80.Evidences for iNOS expression and nitric oxide production in the human macrophages.

机译：在人类巨噬细胞中iNOS表达和一氧化氮生成的证据。
- 作者：Panaro MA;Brandonisio O;Acquafredda A;Sisto M;Mitolo V
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- Production;
- Human;
- Nitric Oxide;
- Arginine;
- 一氧化氮;
- 精氨酸;
81.Fc receptors as potential targets for the treatment of allergy, autoimmune disease and cancer.

机译：Fc受体是治疗变态反应，自身免疫性疾病和癌症的潜在靶标。
- 作者：Takai T;Nakamura A;Akiyama K
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- Fc receptor procedure;
- Malignant Neoplasms;
- Autoimmune Diseases;
- Hypersensitivity;
- 自身免疫疾病;
- 超敏反应;
82.DGAT: novel therapeutic target for obesity and type 2 diabetes mellitus.

机译：DGAT：肥胖和2型糖尿病的新型治疗靶标。
- 作者：Subauste A;Burant CF
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- Obesity;
- novel;
- Therapeutic;
- Enzymes;
- Diabetes Mellitus;
- Non-Insulin-Dependent;
- 肥胖症;
- 酶类;
- 糖尿病;
- 非胰岛素依赖型;
83.A discussion of natural rubber latex allergy with special reference to children: clinical considerations.

机译：讨论天然橡胶胶乳过敏症，特别是儿童：临床考虑。
- 作者：Eustachio N;Cristina CM;Antonio F;Alfredo T
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第3期
- Latex;
- Child;
- Hypersensitivity;
- Rubber;
- Mold;
- NOS;
- 胶乳;
- 儿童;
- 超敏反应;
- 橡胶;
84.Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders.

机译：糖原合酶激酶3的生理作用：潜在作为糖尿病和其他疾病的治疗靶标。
- 作者：Woodgett JR
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- Phosphotransferases;
- Therapeutic;
- glycogen synthase kinase 3;
- Proteins;
- Glycogen Synthase;
- 磷酸转移酶类;
- 蛋白质类;
- 糖原合酶;
85.Dual roles of adiponectin/acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.

机译：脂联素/ acrp30在体内作为抗糖尿病和抗动脉粥样硬化脂肪因子的双重作用。
- 作者：Yamauchi T;Hara K;Kubota N;Terauchi Y;Tobe K;Froguel P;Nagai R;Kadowaki T
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- adiponectin;
- Insulin Resistance;
- Laboratory mice;
- Genome;
- KAI1 Gene;
- 胰岛素抗药性;
- 基因组;
86.SHIP2: an emerging target for the treatment of type 2 diabetes mellitus.

机译：SHIP2：用于治疗2型糖尿病的新兴靶标。
- 作者：Baumgartener JW
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2003年第4期
- Insulin;
- Phosphatidylinositols;
- Diabetes Mellitus;
- Non-Insulin-Dependent;
- 胰岛素;
- 磷脂酰肌醇类;
- 糖尿病;
- 非胰岛素依赖型;
- 磷酸单脂水解酶类;
87.The HIV-1 Tat protein: a multifaceted target for novel therapeutic opportunities.

机译：HIV-1 Tat蛋白：新治疗机会的多方面靶标。
- 作者：Giacca M
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- Proteins;
- Viral;
- HIV-1;
- appeal;
- novel;
- 蛋白质类;
88.Regulators of G protein signaling: potential drug targets for controlling cardiovascular and immune function.

机译：G蛋白信号的调节剂：控制心血管和免疫功能的潜在药物靶标。
- 作者：Cho H;Harrison K;Kehrl JH
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第2期
- Cardiovascular;
- GTP-Binding Proteins;
- Immune System;
- GTP-结合蛋白质类;
- 免疫系统;
89.Therapeutic targeting of interactions between Nef and host cell proteins.

机译：Nef与宿主细胞蛋白之间相互作用的治疗靶向。
- 作者：Saksela K
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- targeting;
- Proteins;
- Cells;
- Therapeutic brand of coal tar;
- g lt;
- 3gt;
- 蛋白质类;
- 细胞;
90.The PAX8/PPAR gamma fusion oncogene as a potential therapeutic target in follicular thyroid carcinoma.

机译：PAX8 / PPARγ融合癌基因作为滤泡性甲状腺癌的潜在治疗靶标。
- 作者：McIver B;Grebe SK;Eberhardt NL
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- Adenocarcinoma;
- Follicular;
- DNA-Binding Proteins;
- Drug Delivery Systems;
- 腺癌;
- 滤泡性;
- DNA结合蛋白质类;
- 药物投与系统;
- 核蛋白质类;
- 癌基因蛋白质类;
- 融合;
91.Therapeutic implications of immune-endocrine interactions in the critically ill patients.

机译：危重病人中免疫-内分泌相互作用的治疗意义。
- 作者：Oberbeck R
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第2期
- Hormones;
- Prolactin;
- Prasterone;
- Discharge (release);
- 激素类;
- 催乳素;
- 普拉睾酮;
92.Participation of Maternal and Fetal CRH in Early Phases of Human Implantation: The Role of Antalarmin.

机译：母体和胎儿CRH在人体植入早期阶段的参与：安他敏的作用。
- 作者：Makrigiannakis A;Zoumakis E;Kalantaridou S;Chrousos G;Gravanis A
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第1期
- Corticotropin-Releasing Hormone;
- Foetal;
- Maternal;
- participation;
- Phase;
- 促肾上腺皮质素释放激素;
93.The utility of proteomic patterns for the diagnosis of cancer.

机译：蛋白质组学模式在癌症诊断中的应用。
- 作者：Conrads TP;Veenstra TD
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第1期
- Pattern;
- novel;
- early diagnosis;
- Diagnostic;
- Proteins;
- 蛋白质类;
94.DI-2-Ethylhexyl Phthalate and Endocrine Disruption: A Review.

机译：DI-2-乙基己基邻苯二甲酸酯与内分泌干扰：综述。
- 作者：Latini G;Verrotti A;De Felice C
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第1期
- Endocrine;
- Disruption;
- NOS;
- Review Publication Type;
- phthalate;
- Chemical compound;
- NOS;
95.The impact of body mass index and type 2 diabetes on breast cancer: current therapeutic measures of prevention.

机译：体重指数和2型糖尿病对乳腺癌的影响：当前的预防性治疗措施。
- 作者：Resta F;Triggiani V;Sabba C;Licchelli B;Ghiyasaldin S;Liso A;Schittulli F;Quaranta M;Paradiso A;Tafaro E;Guastamacchia E
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- Malignant neoplasm of breast;
- Body Mass Index;
- Human Females;
- Diabetes Mellitus;
- Non-Insulin-Dependent;
- 人体质量指数;
- 糖尿病;
- 非胰岛素依赖型;
96.Telomerase as drug and drug target for the treatment of thyroid cancer.

机译：端粒酶作为治疗甲状腺癌的药物和药物靶标。
- 作者：Zeiger MA;Meeker AK
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第3期
- Telomerase;
- Thyroid Cancer;
- therapeutic aspects;
- activate;
- in vivo;
- 端粒;
- 末端转移酶;
97.Evidence for a putative relationship between type 2 diabetes and neoplasia with particular reference to breast cancer: role of hormones, growth factors and specific receptors.

机译：在2型糖尿病和肿瘤形成之间可能存在联系的证据，尤其涉及乳腺癌：激素，生长因子和特定受体的作用。
- 作者：Guastamacchia E;Resta F;Triggiani V;Liso A;Licchelli B;Ghiyasaldin S;Sabba C;Tafaro E
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第1期
- Diabetes Mellitus;
- Non-Insulin-Dependent;
- Malignant Neoplasms;
- Role;
- Insulin Resistance;
- 糖尿病;
- 非胰岛素依赖型;
- 角色;
- 胰岛素抗药性;
98.Structure and function of HIV-1 auxiliary regulatory protein Vpr: novel clues to drug design.

机译：HIV-1辅助调节蛋白Vpr的结构和功能：药物设计的新线索。
- 作者：Zhao LJ;Zhu H
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- HIV-1;
- Industrial machine;
- NOS;
- regulatory;
- Apoptosis;
- novel;
- 脱噬作用;
99.Chemokine-chemokine receptor network in immune cell trafficking.

机译：趋化因子-趋化因子受体网络在免疫细胞运输中的作用。
- 作者：Kim CH
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- Leukocytes;
- Receptors;
- Chemokine;
- Migration;
- Tissues;
- 白细胞;
- 受体;
- 趋化因子;
- 组织;
100.Blocking HIV-1 Vif restores a natural mechanism of intracellular antiviral defense.

机译：阻断HIV-1 Vif可恢复细胞内抗病毒防御的天然机制。
- 作者：Bovolenta C
- 期刊名称：《Current drug targets. Immune, endocrine and metabolic disorders》 | 2004年第4期
- HIV-1;
- Intracellular;
- strategy;
- Blocking;
- Deaminase;

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