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您现在的位置：首页> 中文期刊>皮肤病学与性病学>医药卫生>中华性传播感染杂志（英文版）

中华性传播感染杂志（英文版）

中华性传播感染杂志（英文版）

Chinese Journal of Sexually Tuansmitted Infections
本刊由中华临床医药学会主管、中华性传播感染研究学会主办，香港医药科技出版社出版，面向全世界发行的有关性传播感染研究的专业性学术期刊。主要刊登中国及邻近地区性传播疾病、HIV感染/艾滋病领域的有关临床、实验、免疫学、流行病学和社会学等方面研究的论著、综述、病历报告、述评及通讯等稿件。编委会包括了中国国内（含港、澳、台）及欧美等国外性传播感染领域的知名专家，阵容强大，保证了杂志的专业性和科学性。
  • 发文量：166
  • 被引量：23
  • H指数：0
  • 开始收录时间：2001,1(1)
  • CNKI综合因子：0.0
  • 维普期刊影响因子： -
  • 万方期刊影响因子：0.0
  • 创刊时间：2001
  • 国内刊号/CN：98-0022/HK
    国际刊号/ISSN：1608-6260
  • 发行周期：季刊
    邮发代号：
  • 主管单位：中华临床医药学会
    主办单位：中华性传播感染研究会
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  • 地址：中国深圳市布心路2021号
  • 邮编：518020
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中华性传播感染杂志（英文版） >2005年第1期

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  • 摘要：Objective: For the purpose of understanding the changing process of syphilis histomorphology and its injury mechanism,the ultrastructure of dermatic tissues of secondary syphilis was studied.Methods: Different skin injury tissues of secondary syphilis patients, whose serum RPR and TPHA tests in the lab both appeared positive reaction, were observed through transmission electron microscope (TEM).Results: Inflammations appeared on epidermides and coria,a great deal of neutrocytes, lymphocytes and a small amount of plasma infiltrated them. Karyopyknosis, karyorrhexis,epicyte lysis and mitochondrion vacular degeneration occurred. Spirocheta pallida was distributed on intercellular substances, epicytes and coilagenous fibers. The epicytes were pressed to foveation. Conclusion The pathological change of characteristic tissue ultrastructure reported here is a histomorphological foundation to study the organism injury mechanism caused by syphilis.
  • 摘要：Objectives: To evaluate the efficacy of nested polymerase chain reaction (PCR) with first void urine (FVU) for the diagnosis of Mycoplasma hominis in male patients.Methods: Matched FVU specimens and urethral swabs were collected from 194 male patients with Nongonococcal Urethritis and tested by nested PCR and cell culture. Cell culture was used as a gold standard for evaluating other assay techniques.Results: For FVU nested PCR assay and FVU cell culture,our results showed that the sensitivity was 100% and 93.3%;specificity was 97.0% and 98.2%; positive predictive value (PPV) was 85.7% and 90.3%, negative predictive value (NPV)was 100% and 98.8%, respectively. The total consistency between the two techniques was 97.4 %.Conclusions: For the diagnosis of Mycoplasma hominis in men, nested PCR detecting FVU is a highly sensitive and specific method. First void urine can replace swab culture or PCR in terms of acceptability and feasibility.
  • 摘要：Objective: To investigate the role and clinical significance of p16 protein in Condyloma Acuminatum (CA) and its cancerization.Methods.. The expression of p16 protein was tested in 33 CA samples and 7 cancerized CA samples by immunohistochemical assays.Results: There was abnormal expression of p16 protein in CA and cancerized CA, mainly major protein expression. The p16 protein expresseed in different locations in different cases was as follows: In basal layer cells in normal cuits; in spinous layer, granular layer and stratum corneum layer cells in CA;in keratin pearl peripheral and spinous layer cells in cancerized CA.Conclusion: There was major expression of p16 protein in CA and cancerized CA, and these protein of the two groups might not naturally be the same. Our study indicated that in clinical practice, when major p16 protein expression in CA occurs, it's risk of cancerization shoud be suspected.
  • 摘要：Objective: To evaluate the therapeutic effect of Nd:YAG laser under urethroscope for the treatment of intraurethral Candyloma Acuminata (CA) in males.Method: Nd:YAG laser under urethroscope was employed to remove the warts.Result: Seventeen patients out of eighteen cases with CA were cured after the first procedure. The ure rate was 94.4%.For second treatment, the cure rate was 100% and no relapse occurred after observation for 12 - 4 months.Conclusion: Nd:YAG laser by urethroscope is a very good method for the treatment of intraurethral CA.
  • 摘要：Objective: To analyze the genotypes of CCR5 △ 32,CCR2b-64I and SDF 1-3`A and mutation frequencies of allelic genes in Chinese populations infected with HIV-1.Methods: Genome DNA from peripheral blood mononuclear cells (PBMCs) of 78 HIV-1 infectors was amplified by polymerase chain reaction (PCR). CCR5, CCR2b and SDF1 gene fragments were obtained from restrictive fragment length polymorphism (RFLP) and/or CCR/△32, CCR5m303,CCR2b-64I and SDF1-3' A allelic genes' mutational frequencies were sequenced directly from PCR products.Results: None of CCR5△32, CCR5m303 gene mutation were found in 78 subjects with HIV-1 infection. The allelic gene mutation frequencies of CCR2b-64I and SDF1-3'A corresponding to 14.9-34.0% and 17.6-38.2% of 95% CI, were 22.79% and 26.92% respectively. Their colony distribution conformed to the Hardy-Weinberg equilibrium.Conclusion: The HIV-1 infections found at present are all susceptible population of CCR5△32 and CCR5m303. The polymorphism and frequencies of CCR5△32, CCR5m303,CCR2b-64I and SDFI-3'A alleles from Chinese HIV-1 infected population were disclosed in this study for the first time, which is of significance for studying the genetic resistance to susceptibility to HIV-1 infection as well as AIDS disease progression.
  • 摘要：Objective: To investigate U. parvum (previously Ureaplasma urealyticum biovar 1) and U. urealyticum (previously Ureaplasma urealyticum biovar 2) and their subtypes and serovars in urine specimens of pregnant women.Methods: After collecting 151 specimens and inoculating broth, all broth culture positive (urease positive) specimens were amplified, species were identified and subtyped by using general primers, species-specific, and type-specific primers targeting the multiple banded antigen (MBA) gene sequence.Results: U. parvum was identified in 58 of 151 specimens and U. urealyticum in 18 (both were present in 5, and neither were found in 6). Serovars 3, 1, and 6 were the most common among U. parvum isolates and subtypes 1 and 3 were the most common among U. urealyticum. Multiple serovars among clinical isolates were found.Conclusion: This PCR-based typing system could facilitate studies of the relationship between individual ureaplasma species or subtypes and human diseases.
  • 摘要：Objective: To study the cellular immunity function of patients with early syphilis and the effects on immune modifiers Esberitox N or IFN.Methods: T-lymphocyte subpopulations of the peripheral blood in 44 patients with syphilis and 40 healthy controls were examined by flow cytometry.Results: The number of CD4+ cells and the CD4+/CD8+ ratio in patients with syphilis were found to be significantly lower than those in the control (P＜0.01), while the number of CD8+ cells was higher than that in the control (P＜0.01). The CD4+/CDs+ ratio in those with active disease was lower than that in those who had been cured (P＜0.05). The CD4+ count and the CD4+/CDs+ ratio in those treated with antibiotics alone (Penicillin G or Cephalosporins) were lower than those treated with both antibiotics and immunomodulators (P＜0.05).Conclusions: Cellular immunity in the patients with early syphilis was prominently suppressed, and treatment with immunomodulators may be helpful for the recovery of cellular immunity of these patients.
  • 摘要：@@ CHINA BROKE THE silence this November, hosting the First China AIDS/STD Conference from November 13-16 in Beijing.
  • 摘要：Objective: To compare the consistency of the results from detecting HIV-1 antibody in the paired urine and serum specimens from drug users by ELISA.Methods: The paired urine and serum specimens from 273 drug users detained at a detoxification unit were collected, and the HIV-1 antibodies in the specimens of them were screened by urine and serum ELISA kits, respectively. Results: Of 273 serum specimens, 94 ones showed positive reaction and among 94 counterpart urine specimens, 93 ones also appeared positive reaction. Taking the results together,the consistent rate of HIV-1 antibody screened by urine and serum ELISA kits was 99.6%.Conclusion: The urine ELISA kit, which screened HIV-1 antibody of urine showing almost the same results tested by serum ELISA kit, is reliable. It is proposed that urine ELISA be introduced in many fields.
  • 摘要：Objective: To investigate the depression status of patients with sexually transmitted diseases (STDs).Methods: The depression status of fifty-one hospitalized STD patients was evaluated in a randomized control study using Zung's Quantitative Table. 18 healthy control patients with similar demographic backgrounds were randomly chosen as controls. Patients with scores above or equal to 40 were considered to be suffering from depression.Results: The prevalence rate of depression in the patient group was obviously higher than that of in the control (X2=16.456,P＜0.01). Prevalence of depression was found to be significantly related to occupation (P＜0.05). Though the prevalence was not found to differ significantly between those with a treatment course less than 2 months and those with one longer or equal to 2 months (X2=0.041, P＞0.05), the mean depression scores of the former group were significantly higher than those of the latter (P＜0.01). No significant differences were found between new versus relapsing disease, married versus non-married, male versus female, or differing educational backgrounds.Conclusion: STD patients showed significant prevalence of depression.
  • 摘要：Objective: To clone, sequence and express the primate β-chemokine RANTES genes, hRANTES from H. sapiens and mRANTES from M. Mulatta, in order to explore the possibility of AIDS gene therapy.Methods: hRANTES and mRANTES were amplified by reverse transcription-polymerase chain reaction (RT-PCR)from RNAs extracted from phytoagglutinin (PHA)-activated peripheral blood lymphocytes. hRANTES was cloned,sequenced and expressed in vitro, and mRANTES was directly sequenced for homology comparison.Results: An expected 276 bp fragment was obtained in both amplifications, and sequence data demonstrated a relatively high homology among different copies of hRANTES (97%),and hRANTES was up to 95.6% homologous to mRANTES.When compared with RANTES from other mammals,hRANTES gave rise to a homology ranging from 77% to 86%.The cloned hRANTES was expressed in vitro and a positive signal of RANTES was detected by dot blotting.Conclusion: The full-length of hRANTES sequence was submitted to GenBank and had been released. Our mRANTES sequence is first reported and not yet appeared in GenBank.The successful cloning and expression of hRANTES will provide a basis for AIDS gene therapy in the future.
  • 摘要：These three cases of reinfection syphilis all had complete medical histories, clinical symptoms, and laboratory records of prior primary or secondary syphilis infection. The author held that the main reason for reinfection was failure of diagnosis and treatment of sex partners.
  • 摘要：目的 通过对广州市全职与兼职妓女之间特征性差异的分析,找出淋病和滴虫病在全职妓女中显著高发的危险因素.方法 1998年3月至1999年月10月,我们对纳入本次研究的妓女进行了性病检测和采访式问卷调查.根据有无额外固定收入,我们把妓女分为兼职和全职两类.我们采用单元与多元Logi stic 回归分析法,确定感染淋病和滴虫病的危险因素,分析无固定收入与感染淋病和滴虫病的关系.结果 共有442名全职妓女和524名兼职妓女参与了本次研究.全职妓女的淋病和滴虫病的发病率显著高于兼职妓女.与兼职妓女相比,大多全职妓女受教育程度低,有静脉吸毒史,接待的嫖客多为商人,卖淫场所主要在按摩洗浴中心,无固定性伴.在双变量分析模型中,辍学年龄、嫖客类型、卖淫场所和无固定收入状态与淋病感染密切相关.而静脉吸毒史和在过去12个月中无固定性伴、无固定收入状态是与滴虫感染密切相关的决定因素.结论 妓女中淋病发病率的不同取决于全职妓女与兼职妓女之间不同的文化程度、嫖客类型和卖淫场所.全职妓女中滴虫病的相对高发与她们大多无固定性伴或有静脉吸毒史相关.本次研究表明,应将促进安全套在妓女和嫖客中的使用和提高妓女的健康保护意识作为性病/艾滋病防治的主要策略.%Objective: To describe the different characteristicsbetween full-time sex workers (FTSW) and part-time sex workers (PTSW) in Guangzhou, China, and to determine the risk factors which lead to the significantly higher prevalence of gonorrhea and trichomoniasisamong FTSW.Methods: From March 1998 to October 1999 female sex workers were recruited through various outreach methods, and were interviewed and tested for the presence of sexually transmitted diseases (STDs). In terms of additional regular salary female sex workers were divided into FTSW who didn't have additional regularsalary and PTSW who had additional regular salary.Univariate and multivariate logistic regression analyses were used to identify risk factors for gonorrhea/trichomoniasis and to determine the confounders in the relationship between no regular salary and gonorrhea/ trichomoniasis.Results: A total of 442 FTSW and 524 PTSW entered this study. Prevalence of gonorrhea and trichomoniasis was significantly higher in FTSWcompared to PTSW. FTSW were more likely to have a lower education level, have a history of injecting drugs use since 1990, to recruit clients in a massage/sauna, have businessmen as their clients and not have a steady partner compared to PTSW. In bivariate analyses models, age leaving education, main types of clients and recruitment locations appeared to be the strongest links between no regular salaried position and gonorrhea. A history of injecting drugs and having no steady partner (past 12 months) appeared to be the strongest links in the relationship between no regular salaried position and trichomoniasis.Conclusion: Different education levels, clients, and recruitment locations between FTSW and PTSW may account for the different gonorrhea prevalence among sex workers. The higher prevalence of trichomoniasis among FTSW may be related to the larger proportion of women having no steady partner or a history of injecting drugs. The results suggest strategies to prevent HIV/STDs among female sex workers should include condom negotiation with clients and awareness of seeking health care.
  • 摘要：Objective: To evaluate the value of ligase chain reaction(LCR) in the diagnosis of diplococcus gonorrhoeae in urine.Methods: LCR detection of the urine for Neisseria gonorrhoeae and bacteria culture of discharge was performed simultaneously to 276 patients with urethritis or cervicitis seeking treatment in sex transmitted diseases (STDs) outpatient clinic. For specimens with discordant results, polymerase chain reaction was conducted. The purpose was to detect the respective sensitivity and specificity of bacteria culture and LCR.Results: 24 of 276(8.7%) patients had positive LCR results and 21 of 276(7.6%) were positive for culture.5 specimens had discordant results from LCR and bacteria culture. The sensitivity and specificity of LCR in the diagnosis of gonorrhoeae were 92.3% and 100% respectively.Conclusion: This study showed that LCR had a higher sensitivity and specificity for the diagnosis of gonorrhoeae from urine.%目的 评价连接酶链反应(LCR)技术对尿液中淋病双球菌诊断的意义.方法 对在STD门诊就诊的276例尿道/宫颈炎患者进行分泌物细菌培养及尿液淋球菌LCR检测,对两项结果不符合的标本进行聚合酶链反应(PCR)检测,确定细菌培养、LCR法检测尿液中淋球菌的敏感性、特异性.结果 276例患者中24例LCR检测阳性(8.7％),21例培养阳性(7.6％).5例两项结果不符合者进行聚合酶链反应检测.结果表明LCR的敏感性及特异性分别为92.3％,100％.结论 LCR分析法检测尿液中的淋球菌具有较高的敏感性及特异性.
  • 摘要：Objective: To study the expression of Fas and Bcl-2 proteins on T lymphocyte subsets in the peripheral blood of relapsing patients with condyloma acuminatum (CA) and healthy controls.Methods: Flow cytometry (permeabization and staining procedure with conjugated antibodies) was used.Results: We observed that the expression of Fas protein on CD4+ T lymphocyte subset of CA patients was significantly higher than that of healthy controls ( P＜0.01 ).Conclusions: Increased expression of Fas protein on CD4+ T lymphocyte subset may be a cause of decreased percentage of CD4+ T lymphocyte subset. This induces the increased ratio of CD4+/CD8+.%目的 研究复发性尖锐湿疣(condyloma acuminatum,CA)患者与正常对照者T细胞亚群Fas及Bcl-2蛋白的表达.方法 采用流式细胞仪,结合抗体渗透染色法进行检测.结果 CA患者外周血CD4+T淋巴细胞亚群Fas蛋白的表达较正常人显著增加.结论 CD4+T细胞百分率下降与其高表达Fas蛋白有关.CD4+/CD8+比值下降主要是由于CD4+细胞百分率下降所致.
  • 摘要：目的 检测活化型表皮生长因子受体(EGFR)和转录调节因子E2F在尖锐湿疣中的表达.方法 采用免疫荧光方法观察活化型EGFR和E2F在尖锐湿疣(CA)皮损中的表达情况.结果 活化型EGFR在CA皮损角质形成细胞膜上的表达较正常对照组显著增强(P＜0.01).而且,活化型EGFR和E2F在CA皮损中的双重阳性表达较正常对照组显著增强(P＜0.01).结论 活化型EGFR表达的增强导致核内转录因子的激活而参与CA的增殖病变.%Objective: To study the expression of activated epidermal growth factor receptor (EGFR) and transcription factor E2F (E2F) in Condyloma Accuminata(CA)patients.Methods: Immunofluorescent techniques were used to investigate the expression of activated EGFR and E2F in CA patients.Results: The expression of activated EGFR on the membrane of epithelial cells in CA lesions was significantly greater compared to expression levers in the control group (P＜0.01). Moreover, the co-expression of activated EGFR and E2F was significantly increased compared to the control group (P＜0.01).Conclusion: Our observations suggest that the increase in activated EGFR expression may stimulate hyperplasia in CA patients through the activation of transcription factor E2F.
  • 摘要：无
  • 摘要：Objective: To investigate the possible presence of an active efflux system in resistance to fluoroquinolones in Mycoplasma hominis.Methods: The resistant strains of M. hominis were selected from one hundred and three clinical strains of M. hominis by broth microdilution method. The accumulation of ciprofloxacin in M. hominis and the influence of carbonyl cyanide m-chlorophenyl- hydrazone (CCCP) and reserpine were measured by a fluorescence method.Results: Two resistant strains and two susceptible strains of M. hominis were selected in vitro. The accumulation of ciprofloxacin for resistant strains is lower than that of susceptible strains. CCCP and reserpine had different influence on clinical strains of M.hominis. Reserpine could dramatically increase the accumulation of ciprofloxacin, however CCCP had a little effect on it.Conclusion: These results suggest that the presence of an active efflux system implicated in the fluoroquinolones-resistant in M. hominis.%目的 探讨人型支原体对氟喹诺酮类药物的耐药性是否由于一种主动外排系统的存在所致.方法 采用肉汤微量稀释法从103株临床人型支原体中筛选出耐药菌株.用荧光法测定盐酸环丙沙星在人型支原体内的蓄积量及碳酰氰间氯苯腙(CCCP)和利血平产生的影响.结果 体外分离出两组人型支原体耐药菌株和两组敏感菌株.盐酸环丙沙星在耐药株中的蓄积量低于敏感株.CCCP和利血平对临床菌株产生的影响有差异.利血平能够显著增加盐酸环丙沙星的蓄积量,而CC C P在此方面作用不明显.结论 主动外排系统的存在可能是人型支原体对氟喹诺酮类药物耐药机制的一部分.
  • 摘要：Objectives: To provide references for HIV/AIDS-related health education strategies through survey on HIV/AIDS-related knowledge, attitude and determinants of HIV/AIDS awareness.Methods: The study subjects were selected by random interception in a downtown street of Guangzhou city on World AIDS Day-December 1,2002. The uniform questionnaires were finished by means of selfadministration.Results: Two hundred questionnaires were distributed and 147 qualified questionnaires were collected.The results showed, the awareness rate of HIV/AIDSrelated knowledge was 63.3%, and awareness rate of transmission routes was 76.2%, whilst non-transmission route was 60.5%; the awareness rate of transmission was 59.2%; the awareness rate of prevention was 47.0 %; the positive attitude to people living with HIV/AIDS was 65.6%. Multiple variable Logistic regression analysis showed the determinants of HIV/AIDS-related knowledge were education level, age,marital status and gender, of which people with high level of education, young age and the group of male and married had better awareness of HIV/AIDS.Conclusion: Current HIV/AIDS-related knowledge of urban residents is relativly low, especially for the non-transmission route, hence further HIV/AIDS-related education should be strengthened, especially focusing on non-transmission route to eliminate discrimination over people living with HIV/AIDS.Further, education efforts also should be put on female population, unmarried population and poorly educated population.%目的 调查城市居民有关艾滋病的知识和对艾滋病的态度及其影响因素,为进一步开展艾滋病知识的宣传教育提供依据.方法 于2002年12月1日,世界艾滋病日,在广州市中心街头随机抽取过路行人进行调查,调查表采用自填方式.结果 在发出的200份问卷中,收回147份有效问卷.对艾滋病有关知识的知晓率为63.3％,知道其传播途径的占76.2％,同时知道不会传播艾滋病的途径的占60.5％;对艾滋病的全面认知率为59.2％;知道如何预防的占47.0％;对艾滋病患者持积极态度的占65.6％.采用多元回归分析法得出艾滋病相关知识的影响因素包括文化程度、年龄、婚姻状况和性别.文化程度高、年轻人、男性群体和已婚者对艾滋病有较好的认识.结论 目前,城市居民对艾滋病的认知程度还相对较低,应加强对该人群的宣传教育,重点应放在对女性人群、未婚人群和文化程度低者的教育上.要让人们进一步了解不传播艾滋病的途径,以消除对艾滋病病毒感染者的歧视.
  • 摘要：目的 观察单纯疱疹病毒2型(HS V-2)对单一核细胞产生肿瘤坏死因子α(TNF-α)和白介素-6(IL-6)的影响,探讨单一核细胞在H S V-2感染中的作用.方法 用HSV-2(333株)感染单一核细胞,于病毒感染1,3,5,7日收集细胞培养上清液,用ELISA法检测TNF-α、IL-6的含量.结果 HSV-2感染后1日,单一核细胞分泌TNF-α水平显著降低.HSV-2感染后1,3日,单一核细胞分泌IL-6水平显著降低,以后,病毒感染单一核细胞分泌TNF-α、IL-6水平逐渐增高,到第7日达到对照组水平.结论 HSV-2能抑制单一核细胞分泌TNF-α和IL-6.而这两种细胞因子在HSV-2致病和机体免疫中起重要作用.%Objective: In order to detect the role of monocytes in HSV-2 infection, we studied the effect of herpes simplex Virus-2 infection on the production of tumor necrosis factor (TNF- α ), interleukin-6 (IL-6) secreted by monocytes.Methods: Monocytes were infected by HSV-2 (333Strain). Culture supernatants were collected at 1, 3,5, 7 days post-infection. The levels of TNF- α, IL-6were measured by enzyme-linked immunosorbent assay (ELISA).Results: The levels of TNF- α secretion by monocytes significantly decreased on first day postinfection. The levels of IL-6 significantly decreased on first and third days post-infection, and then gradually increased to the control on seventh day postinfection.Conclusions: TNF- α and IL-6 production by monocytes was inhibited during HSV-2 infection. The production of cytokines may play an important role in herpes simplex viurs-2 pathogenicity and immunity.
  • 摘要：Objective: To evaluate the clinical utility of testing serum anti-treponema pallidum IgM antibody in the diagnosis of syphilis patients.Methods: Seventy-two cases of syphilis were tested for specific IgM antibody with ELISA, and the results were compared with RPR and TPPA.Results: The sensitivity of IgM antibody was 73.3%(11/15) in primary syphilis, 88.9% (16/18) in secondary syphilis, and there was no significant difference between these values (x2=1.6363, P＞0.10). The sensitivity of IgM antibody in diagnosing latent syphilis was only 26.1% (6/23), much lower than the detection rate in symptomatic early syphilis (x2=17.6189, P ＜0.005). RPR and TPPA were both 100% sensitive in latent and early symptomatic syphilis. Two were positive for IgM in the 16 cases who had received regular treatments 2 to 24 months before enrolled.Conclusions: Specific IgM antibody detection does not appear superior to RPR and TPPA in diagnosing primary syphilis. The diagnosis of latent syphilis should mainly rely on RPR and TPPA, since there are low titers of IgM antibody at that stage. IgM antibody testing alone should not be recommended for monitoring syphilis development or treatment efficacy. Further studies should be concerned.%目的 评价抗苍白螺旋体IgM抗体检测对梅毒的临床意义.方法 用酶联免疫吸附测定法对72例梅毒患者进行特异性I Gm抗体检测,并与RPR、TPPA结果进行比较分析.结果 血清抗苍白螺旋体IgM抗体在一期梅毒的阳性率为73.3％(11/15),在二期梅毒的阳性率为8 8.9％(16/18),二者比较无显著性差异(x2=1.6363,P＞0.10).在潜伏梅毒,IgM抗体阳性率为26.1％(6/23),显著低于早期显性梅毒(x2=17.6189,P＜0.005).在一期、二期和潜伏梅毒,RPR和TPPA的阳性率均为100%.入组前2-24个月已经给予正规抗梅治疗的梅毒16例,其中IgM抗体阳性2例.结论 在本研究中,检测特异性IgM抗体诊断一期梅毒并不优于RPR和TPPA.IgM抗体在潜伏梅毒敏感性低,其诊断应依靠RPR和TPPA.目前不推荐单独检测抗梅毒IgM抗体来监测病情和判断疗效.抗苍白螺旋体I Gm抗体的临床意义有待更深入的研究.
  • 摘要：目的 通过对尖锐湿疣(CA)患者外周血T淋巴细胞亚群及胞内细胞因子分泌水平的研究,探讨尖锐湿疣可能的免疫机制.方法 采用三色和双色荧光抗体染色技术经流式细胞仪检测20例CA患者外周血T淋巴细胞亚群及CD4+T细胞、CD8+T细胞内IL-2、IL-4、IL-12、IFN-γ染色阳性细胞百分率.结果 CA患者CD3+T细胞、CD4+T细胞、CD4+/CD8+比值明显低于正常对照组(P＜0.01);CD4+T细胞内IL-2、IL-12、IFN-γ阳性细胞百分率较正常对照组明显下降(P＜0.01),IL-4阳性细胞百分率与正常对照组无明显差异(P＞0.05);CD8+T细胞内IL-2、IL-12阳性细胞百分率较正常对照组明显下降(P＜0.01),IFN-γ、IL-4阳性细胞百分率与正常对照组无明显差异(P＞0.05).结论 CA患者存在T细胞亚群和Th1/Th2型细胞因子及Tc1/Tc2失调,这在CA的发生发展中可能起重要作用.%Objective: To study the immunological mechanisms of Condyloma acuminata(CA) through investigating T lymphocyte subset levels and cytokine profile in the peripheral blood of patients with Condyloma Acuminata.Methods: Tricolor and bicolor immunofluorescent staining antibody of cell surface antigen and intracellular IL-2, IL-4, IL-12, IFN- γ in CD4+ and CD8+ Tlymphocytes from 20 patients with CA were performed and followed by flow cytometry.Results: The number of CD3+T, CD4+T-lymphocytes cells and CD4+/CD8+T cells ratio were significantly decreased(P＜0.01) in patients with CA Compared to controls, and IL-2, IL-12, IFN- γ production in CD4+T cells was decreased(P＜0.01), IL-4 and IFN- γ production in CD4+T cells was not significantly different(P＞0.05), while IL-2 and IL-12 production in CD8+Tc cells was decreased(P＜0.01),whereas IFN- γ and IL-4 producing in CD4+T cells were of no significantly difference(P＞0.05).Conclusions: There was an imbalance of T lymphocyte subsets, Th1/Th2 cytokines and Tc1/Tc2 in the peripheral blood of CA patients, which may play an important role in the pathogenesis and progression of CA.
  • 摘要：@@ IN JUNE, 2002, a 58-year-old man came to our hospital for pustules of his palms and soles. Half a year earlier, erythema appealed in both his palms and soles without obvious cause, scales, pains or itches. Then grain-sized pustules appeared without drying up and scab formation.
  • 摘要：Objective: To investigate the efficacy of combination of circumcision and microwave on genital warts in uncircumcised men.Methods: A randomized, prospective study of 109uncircumcised adult men with genital warts was conducted in a STD clinic in Zhanjiang, Guangdong. One group (n=54) received microwave therapy only, while the other group (n=55) was taken the combination of circumcision and microwave therapy. The recurrences were observed at the end of months 3, 6 and 12, and operative complications were also recorded.Results: There were no significant differences in the mean age and duration of the disease between two groups (P＞0.05). No serious operative complications were documented. The recurrence rate in circumcision plus microwave group was markedly lower than that in microwave group (12.7% vs 29.6%, P＜0.05),while the differences in early and late recurrences between two groups showed no statistical significance (P＞0.05).Conclusion: Circumcision can be safely performed under local anesthesia in an outpatient setting. Combination of circumcision and microwave can produce excellent effect as well as less tissue damage,therefore, it may be ideal for uncircumcised patients with extensive condylomas.%目的 对未接受过包皮环切手术的尖锐湿疣患者,给予微波与包皮环切联合治疗,并观察其疗效.方法 随机抽取某性病门诊109名未做过包皮环切手术的成年尖锐湿疣患者,将其分为两组进行前瞻性研究.一组(54人)接受单纯微波疗法,另一组(55人)接受微波与包皮环切联合疗法.我们观察到在第3,6和12个月后有复发出现,并记录术后合并症的发生情况.结果 两组间的平均年龄和病程无显著性差异(P＞0.0 5).未发现严重的术后并发症.微波与包皮环切联合治疗组的复发率明显低于单纯微波治疗组(12.7％和29.6％,P＜0.05),而两组间早期与后期的复发率差异无统计学意义(P＞0.05).结论 包皮环切术是一种安全的门诊手术,在局麻状态下即可进行.微波与包皮环切联合疗法的疗效显著,组织损伤小,是未接受过包皮环切手术的尖锐湿疣患者可选择的理想疗法.
  • 摘要：Objective: To investigate the roles of interleukin-2(IL-2) and interleukin-10 (IL-10) in pathogenesis of early syphilis.Methods: The serum levels of IL-2 and IL-10 in 48patients with early syphilis were detected by ABCELISA.Results: (1) The level of IL-2 in the patients with early syphilis was significantly higher than that in healthy controls, while that of IL-10 was lower (P＜0.001 and P＜0.001). (2) The levels of IL-2 and IL10 were almost identical in patients with primary and secondary syphilis (P＞0.05), as well as between different RPR titers (P＞0.05). (3) After therapy, the level of IL-2 decreased markedly (P＜0.05), while that of IL10 increase (p＞0.05). (4) A significant correlation was found between the serum levels of IL-2 and IL-10 (r=0.5385 P＜0.05).Conclusions: Th1 up-regulation occurs in patients with early syphilis, and plays an active role in fighting against TP infection.%目的 探讨细胞因子IL-2和IL-10在早期梅毒发病中的作用.方法 采用ABC-ELISA技术检测48例早期梅毒患者血清IL-2和IL-10水平.结果 (1)早期梅毒患者血清IL-2水平明显高于正常对照组,IL-10水平明显低于正常对照组(P值均＜0.001).(2)一期梅毒患者血清IL-2和IL-10水平与二期梅毒无明显差异(P值均＞0.05),不同R P R滴度间IL-2和IL-10水平无明显差异(P值均＞0.05).(3)治疗后IL-2水平明显下降(P＜0.05),IL-10水平上升不明显(P＞ 0.05).(4)IL-2和IL10之间呈正相关(r=0.5 3 8 5,P＜0.05).结论 早期梅毒出现Th1上调,在抵御TP感染过程中发挥积极作用.
  • 摘要：Objective: To investigate the transmission ratio and epidemiology of Chlamydia trachomatis (Ct) and Ureaplasma urealyticum (Uu) between regular sexual partners.Methods: We collected secretion specimens of genitourinary tract from sexual partners who attended our clinic during the period from May 1, 1999 to May 31,2000 and then detected Ct and Uu in the specimens.Results: The inconsistent rate of Ct and Uu infected between sexual partners was 59.22% and 38.92%respectively. There were no correlations between patients' age and the inconsistent rate of Ct and Uu infected (P＞0.05). The most common inconsistency between regular partners was seen in man with Ct infection while in female with Uu infection; and in man with concurrent infection of Ct while in female only with Uu; or in man with Ct infection while in female no Ct and Uu were detected.Conclusion: The sexual transmitting ability of Ct and Uu is not as active as we have expected.%目的 调查沙眼衣原体(Ct)和解脲支原体(Uu)在固定性伴之间的传播比率和流行病学状况.方法 1999年5月1日至2000年5月31日期间夫妻(性伴)双方均在我院性病门诊就诊的患者,取泌尿生殖道分泌物标本检测Ct和Uu.结果 固定性伴之间Ct和Uu感染的不一致率分别是59.22％和38.92％,患者的年龄与这两种病原体感染的不一致率均无明显相关性(P＞0.05);固定性伴之间这两种病原体感染的不一致通常表现为:男性感染Ct/女性感染Uu、男性合并感染Ct和Uu/女性只感染Uu、男性感染Ct/女性未检出这两种病原体.结论 尽管一方感染了沙眼衣原体和/或解脲支原体,即使有性接触,另一方被感染的比率并不高,推测这两种病原体的性传播力并不强.
  • 摘要：青霉素是治疗梅毒的首选药物,对青霉素过敏者可选用红霉素、四环素治疗.红霉素的疗效不如青霉素,大剂量口服时易出现胃肠道反应[1,2].
  • 摘要：Background: Commercial sex workers and clients are important core populations in the transmission of sexually transmitted diseases (STDs) and human immunodeficiency virus (HIV) infection. Research on the frequency and determinants of condom use in commercial sex workers and their clients is important in increasing condom use and reduction of the STD/HIV.Burden.Objectives: To establish the frequency of and factors related to intention to use condoms and actual condom use in commercial sex contacts and to determine the differences in condom use between sex workers and clients.Methods: Incarcerated commercial sex workers (ICSW) and male STD clinic attendees were recruited into a cross-sectional study to obtain data on the frequency and factors associated with intention to use condoms and condom use in commercial sexual contacts with an interviewer-administered questionnaire.Consistent condom use in ICSWs and never using condoms in male STD clinic attendees were analyzed using univariate and multivariate logistic regression models.Results: The frequency of reported consistent in tention to use condoms and reported actual condom use was 62% and 50.6%, respectively among 158 ICSWs. For male STD clinic attendees, the proportion of reported consistent intention to use condoms and reported actual condom use was 10% and 20.7%,respectively. The factors positively influencing the consistent intention to use condoms were pregnancy preventing measures and the belief of condom efficacy in the prevention of STD/HIV, whereas the factor associated with actually consistent condom use was pregnancy-preventing measure in ICSWs. Factors associated with no intention to use condoms were low income,low STD/HIV knowledge level and the frequency of visiting CSW. The latter factor was also associated with never using condoms in male STD clinic attendees.Conclusions: Consistent condom use during com mercial sex contacts was low, especially in clients.Greater effort is needed in condom promotion program in order to raise the level of condom use in commercial sex contacts.%背景 妓女和嫖客是传播性病和艾滋病的高危人群.为了在高危人群中促进安全套的使用,调查安全套在妓女和嫖客中的使用频率和影响因素十分重要.目的 调查商业性行为中安全套使用的频率和影响因素,分析安全套在妓女和嫖客中使用情况的差异.方法 在押的妓女和性病门诊的男性患者参与了本次调查.采用横断面调查的方法,以问卷形式收集了商业性行为中安全套使用的频率和影响因素的相关资料.并用Logistic回归模型对上述资料进行分析.结果 在158名妓女中,报告的安全套的意图使用率和实际使用率分别为62％和50.6％,而在性病门诊男性患者中,则分别为10％和20.7％.影响安全套使用意图的积极因素是避孕和预防性病/艾滋病.而妓女一贯使用安全套的目的则是避孕.低收入、性病/艾滋病知识的缺乏和光顾妓女的次数影响安全套的使用,也是性病门诊男性患者不使用安全套的主要原因.结论 在商业性行为中,尤其是嫖客一方,安全套的使用率很低.应继续在高危人群中推广安全套的使用.

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