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生殖与发育医学：英文版

生殖与发育医学：英文版

本刊是国家计划生育委员会为将我国计划生育领域的最新研究成果向国内外报道而委托《生殖与避孕》编辑部编辑出版的一本国家级正式注册公开发行的学术性全英文刊物，创刊于1989年，向国内外公开发行。本刊主要刊载生殖健康领域内的基础及应用成果；国内外生殖健康领域的研究动态和进展；新技术和新方法。同时展开不同学术观点的讨论，内容包括生殖健康领域的临床、生殖生物学、生殖药理学、流行病学、遗传与优生、妇产科学、男科学、生殖健康、避孕药具研究等。读者对象为生物医学领域的科研人员和临床医生及实验室研究人员、各级人口与计划生育领域的科研和管理人员及关有的生殖健康教育工作者。
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  • 发文量：30
  • 被引量：1
  • H指数：0
  • 开始收录时间：1989,1(1)
  • CNKI综合因子：0.0
  • 维普期刊影响因子： 0.0
  • 万方期刊影响因子：0.08
  • 创刊时间：1989
  • 国内刊号/CN：10-1442/R
    国际刊号/ISSN：2096-2924
  • 发行周期：季刊
    邮发代号：
  • 主管单位：国家计划生育委员会
    主办单位：中华医学会;上海市计划生育科学研究所
生殖与发育医学：英文版-联系信息
  • 主编：高尔生
  • 电话：021-64432022
  • 邮箱：randc@sippr.stc.sh.cn
  • 地址：上海斜土路2140号
  • 邮编：200032
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生殖与发育医学：英文版 >2021年第2期

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  • 摘要：Objective:To study the safety of mifepristone on thyroid hormone level by using hyperthyroidism pregnant model in mouse to simulate the process of medical abortion and observe the changes of thyroid hormone during abortion.Methods:A total of 60 female Institute of Cancer Research(ICR)mice aged 6-8 weeks were divided into control group,control group with 0 mgRU486 group(control-0 mgRU486),control group with 2 mgRU486 group(control-2 mgRU486),hyperthyroid pregnant mice with 0 mgRU486 group(hyper-0 mgRU486),hyperthyroid pregnant mice with 2 mgRU486 group(hyper-2 mgRU486),and hyperthyroid pregnant mice with 20 mgRU486 group(hyper-20 mgRU486).In the hyperthyroidism groups,L-thyroxine sodium was intraperitoneally injected every day at 30μg·kg^(−1)·day^(−1) until the end of the experiment.On the 7^(th) day of the experiment,free triiodothyronine(FT3),free tetraiodothyroxine(FT4),thyroxine(TT4),and thyroid-stimulating hormone(TSH)levels were tested.The mice in the control groups and those in the experimental groups were paired with the male mice(2:1)on the 10^(th) day of the experiment,and the caging was recorded.On the 8^(th) day of pregnancy(day 8),pregnant mice were subcutaneously injected with mifepristone in different doses and were sacrificed 6 h later.Pregnancy rate and the number of embryos were recorded.Thyroid tissues were observed by hematoxylin and eosin(HE)staining.Serum TSH level was determined by radioimmunoassay.Results:Six hours after injection with mifepristone,serum FT3,FT4,and TT4 levels of pregnant mice were all increased.The increased levels in the mice under hyperthyroidism were different from those in the control groups(P<0.05).There was no difference in the embryo number and pregnancy rate between the experimental and the control groups;HE staining indicated that there was no significant change in microscopic features before and after mifepristone administration.Conclusion:Serum thyroid hormone level of mice under hyperthyroidism was significantly increased after mifepristone administration.Therefore,mifepristone should be avoided when hyperthyroidism has not been controlled.
  • 摘要：She serves as the Secretary General of International Federation of Fertility Societies,an Executive Member of Asia Pacific Initiative on Reproduction(ASPIRE,2014-2016),a Board Member of Preimplantation Genetic Diagnosis International Society,and the Director of Gynecological Endocrinology Department of Obstetrics and Gynecology Society in Chinese Medical Association.
  • 摘要：Objective:Testosterone plays an essential role in maintaining spermatogenesis and male fertility,and the primary known source of testosterone is testicular Leydig cells,which are regulated by luteinizing hormone(LH).However,whether any other ways of testosterone secretion exist still remains unknown.Methods:Transmission electron microscopy was used to detect testicular extracellular vesicles(EVs),which were isolated by an ultracentrifuge process.Separately,the concentrations of follicle-stimulating hormone(FSH),LH,and testosterone were measured by enzyme-linked immunosorbent assay.Results:Some EVs were found by tail vein injection to be present in mouse testes that elevate the circulating testosterone and LH levels in the blood,but do not affect FSH.Separately,they also promote testosterone production in the TM3 Leydig cell line in vitro.To determine whether the EVs from spermatogonia were involved in the secretion of testosterone,we used spermatogonial stem/progenitor cell line C18-4 cells and revealed that C18-4 cells promote production of testosterone in the TM3 Leydig cell line using the EVs.Conclusions:EVs in mouse testes likely originate from spermatogonia and involved in the regulation of the serum testosterone.Our results provide a new mechanism for the regulation of testosterone production.
  • 摘要：Objective:To evaluate whether preimplantation genetic testing for aneuploidy(PGT-A)with comprehensive chromosome screening increases live birth rate(LBR)in normal karyotype couples with recurrent pregnancy loss(RPL).Methods:A retrospective cohort follow-up study of 506 couples with RPL was conducted between April 2014 and March 2017.Couples were allocated to two groups according to their decision to choose PGT-A or not.The primary outcome was LBR per start/transfer cycle;secondary outcomes were ongoing pregnancy rate and miscarriage rate.Statistical analyses were conducted using univariate and multivariate logistic regression models adjusted for maternal age.Results:LBR per start(26.6%vs.15.4%,relative risk[RR]:2.66,95%confidence interval[CI][1.69-4.20],P<0.0001;adjusted RR[aRR]:2.40,95%CI[1.49-3.86],P=0.0004)and per transfer(44.9%vs.25.1%,RR:3.00,95%CI[1.96-4.60],P<0.0001;aRR:2.64,95%CI[1.68-4.14],P<0.0001)was significantly higher in the PGT-A group than in the non-PGT-A group.The miscarriage rate was significantly lower in the PGT-A group compared to the non-PGT-A group(15.7%vs.34.6%,RR:0.27,95%CI[0.13-0.57],P=0.00005;aRR:0.26,95%CI[0.12-0.57],P=0.0007).Conclusions:LBR per start cycle following PGT-A is significantly higher,and risk of miscarriage is significantly lower among infertile couples with RPL,irrespective of maternal age.PGT-A should be recommended to infertile couples with RPL.
  • 摘要：Objective:To investigate factors that may be associated with the recurrence of deep infiltrating endometriosis(DIE)and DIE-related symptoms.Methods:Starting in September 2014,women with a confirmed diagnosis of DIE based on surgical and histological findings were included in the prospective study with a 2-year follow-up in our hospital.A total of 84 consecutive patients were included,all of whom underwent laparoscopic surgery.The data were obtained from the medical records of the patients.Follow-up data,including presence of pain as assessed using the visual analog scale(VAS)score and ultrasonography/magnetic resonance imaging findings,were obtained at 3,6,9,12,and 24 months postoperatively.Variables,such as age,body mass index,severity and duration of symptoms,size and location of the lesion,and pre-and postoperative medical treatment,were evaluated using univariate and multivariate analyses to identify factors correlated to recurrence.Results:A total of 11(13.1%)patients presented with recurrence,with a mean time to recurrence of 14.2 months.The univariate analysis showed that the longer duration of menstruation(7.4 vs.6.0,P=0.010),the more advanced revised American Fertility Society(rAFS)stage(Stages I and II vs.III and IV,χ^(2)=9.964,P=0.001),the higher VAS score for dysmenorrhea(9.4 vs.5.2,P=0.001),and the more severe pain during defecation(7.8 vs.4.8,P=0.016)were positively correlated to DIE recurrence.However,the multivariate analysis also revealed that a more severe dysmenorrhea and advanced rAFS stage were the independent factors associated with the recurrence of DIE,with an odds ratio of 1.895(confidence interval[CI]:1.061-3.385,P=0.031)and 4.310(CI:1.091-17.028,P=0.037),respectively.Conclusions:More than 10%of patients presented with recurrence of DIE 2 years after surgery.Recurrence of DIE was more common in patients who complained of more severe dysmenorrhea and had an advanced rAFS stage.
  • 摘要：Objective:Carbophos(CAR)is an organophosphate that is most capable of producing free radicals and inducing alteration in some of the male reproductive parameters.Resveratrol(RES)is an herbal polyphenol and exerts beneficial antioxidant effects.This study aimed to evaluate the effects of RES against CAR-induced alteration in reproductive parameters of male rats.Methods:In this experimental study,48 male rats were randomly assigned to eight groups:Group 1:Normal control(saline)group;Group 2:CAR control(250 mg/kg)group;Groups 3-5:2,8,and 20 mg/kg RES,respectively,groups;Groups 6-8:CAR plus 2,8,and 20 mg/kg RES,respectively,groups.The agents were administered intraperitoneally and by gavage daily for 65 days.Sperm parameters,testis malondialdehyde(MDA)levels,total antioxidant capacity,testosterone levels,and germinal layer height were evaluated and compared among these groups.Results:No significant alterations were observed in RES groups(with different doses)compared to the normal control group(P>0.05).The levels of all parameters except MDA(which decreased)significantly increased in the CAR plus RES(with different doses)groups compared to the CAR control group(P<0.01).Conclusions:RES attenuates the toxic effect of CAR on some of the male reproductive parameters.
  • 摘要：Objective:To develop a model to predict the risk of postpartum hemorrhage(PPH)following cesarean delivery in women with a scarred uterus.Methods:A total of 4,637 pregnant women with scarred uterus who underwent a cesarean delivery at a large hospital between January 2014 and December 2017 were enrolled.The women were divided into PPH(n=287)and non-PPH(n=4,350)groups.A model to predict PPH(blood loss≥1,000 mL within 24 h following cesarean delivery)was developed using multivariate logistic regression analysis.Receiver operating characteristic curve was drawn,and the area under curve(AUC)was calculated.Results:The incidence of PPH was 6.19%(287 of 4,637 women).Seven independent risk factors were associated with PPH:maternal age(odds ratio[OR]=1.42,95%confidence interval[CI]:1.02-1.97),previous gravidity(OR=1.24,95%CI:1.01-1.50),placental location(posterior wall of uterus,OR=0.69,95%CI:0.47-1.02;other locations,OR=1.21,95%CI:0.81-1.80),placenta previa(incomplete placenta previa,OR=10.51,95%CI:5.99-18.42;complete placenta previa,OR=31.65,95%CI:21.07-47.54),placenta accreta(OR=6.39,95%CI:4.02-10.16),hypertensive disorders of pregnancy(OR=2.27,95%CI:1.40-3.68),and fetal position(breech position,OR=2.07,95%CI:1.19-3.60;transverse position,OR=1.07,95%CI:0.48-2.41).A predictive model with AUC of 0.89 was developed(95%CI:0.86-0.91,P<0.001).Conclusions:A model was developed to predict PPH following cesarean delivery in women with a scarred uterus.
  • 摘要：Objective:Screening variants underlying the single-gene disorder in the general population can help reduce the incidences of birth defects.To determine the most prevalent pathogenic variants causing autosomal recessive diseases,we investigated the frequencies of these variants in six major geographic ancestry groups from Exome Aggregation Consortium(ExAC)database and 26 populations from the 1,000 Genome Project,including three Chinese ethnic groups.Methods:We selected 64 autosomal recessive diseases and collected corresponding causal genes and variants from ClinVar for the analysis.The RS(reference single-nucleotide polymorphism)IDs of these variants were used to search the corresponding VCF file from the 1,000 Genomes Project and ExAC databases.We calculated the frequencies of heterozygotes of each disease variants in the 1,000 Genomes Project and ExAC samples and compared the distribution of disease alleles among different populations.Results:Our analysis revealed that 1,151/212 variants were carried by 60,706/2,504 individuals sequenced in the ExAC/1,000 Genomes Project.The average number of autosomal recessive disease alleles carried by samples from ExAC and 1,000 Genomes Project were 0.53 and 0.68,respectively.These disease alleles showed differential distribution among populations,and some disease alleles were significantly enriched in certain ethnic groups.In addition,1-2 main pathogenic variants were identified in each disease.Meanwhile,several ClinVar variants with relatively high frequency(>1%)in the samples were found to be benign instead of“conflicting evaluations of pathogenicity.”Conclusions:Our observations revealed that main pathogenic variants existed in certain autosomal recessive disease,suggesting that screening of disease hypermutations in different populations is valuable in reducing the occurrence of birth defects.
  • 摘要：Age-related chromosomal aneuploidy is associated with the reduction of cohesin in meiosis.There are many complicated factors affecting the metabolism of cohesion,including the hyperactive separase,abnormal Shugoshin protein degradation,oxidative damage,increased intracellular pH in oocytes,abnormal metabolism of spindle assembly checkpoint,anaphase-promoting complex,and age-related reproductive hormones,which are summarized in the review.
  • 摘要：Endometriosis is a common gynecological disorder characterized by pelvic pain,heavy menstruation,and infertility.The clinical diagnosis of endometriosis is often delayed 8-10 years after the onset of symptoms due to the lack of an effective and reliable noninvasive diagnostic method.In recent years,a number of research studies have reported using microRNAs(miRNAs)as potential noninvasive biomarkers for diagnosing endometriosis.Because miRNAs regulate gene expression,the differential expression of miRNAs in endometriosis patients also provides insight on dysregulated gene expressions in the pathogenesis of endometriosis.In this review,a number of global profiling studies(published through July 2019)that investigated the differential expression of miRNAs in endometriosis were identified.Based on these findings,the role of miRNAs in the pathogenesis of endometriosis,particularly with regard to the dysregulation of endometrial functions,cell cycle regulation,proliferation of endometrial stromal cells,and angiogenesis,was discussed.The potential of these miRNAs as noninvasive diagnostic biomarkers of endometriosis was also discussed.
  • 摘要：Endocervical curettage(ECC)is an optional practice during colposcopy,and the indication for endocervical curettage(ECC)is controversial between Europe and the USA.Here,we explored the value of ECC in a specific situation.An elderly post-loop electrosurgical excision procedure woman,who had undergone a colposcopy 4 months before,went for her follow-up and abnormal cytology was found,and both the ECC and punch biopsy showed negative results.Then,a second ECC was performed,which led to the diagnosis of a high-grade squamous intraepithelial lesion.This case report shows that ECC is useful for diagnosing elderly women with Type 3 squamocolumnar junction.
  • 摘要：There has been a very rapid development in the area of preimplantation genetic testing(PGT)since the first baby applied PGT technology in the world was born in the last 30 years.As an alternative treatment of prenatal diagnosis,the transfer of the fetus with normal testing result has benefited many families.PGT is mainly classified into PGT for aneuploidies(PGT-A),PGT for chromosomal structural rearrangement(PGT-SR),and PGT for monogenic/single-gene defects(PGT-M).Here,we reviewed the application,development,limitations,and challenges of the current PGT in reproductive medicine.
  • 摘要：Objective:Mutations in NUP107 have been discovered in patients with premature ovarian insufficiency and may have tissue-specific effects in ovarian development.However,the role of NUP107 in human granulosa cell(GC)function and female fertility still remains unknown.In this study,we used RNA interference to investigate how NUP107 dysfunction influences GCs and ovarian development.Methods:Immunohistochemical staining was used to detect the expression of NUP107 in ovaries.Cell counting kit-8 assay,real-time cell analysis,and flow cytometry were used to explore cell proliferation and apoptosis,and an enzyme-linked immunosorbent assay was used to assess the estrogen concentrations.Quantitative real-time reverse transcription-quantitative polymerase chain reaction and Western blot analyses were used to determine the expression of NUP107 and functional receptors.Results:Knockdown of NUP107 expression had little effect on the growth and number of GCs.Further study confirmed that knockdown of NUP107 may interfere with estrogen synthesis in GCs and their sensitivity to the regulation of follicle-stimulating hormone(FSH)by decreasing the expression of estrogen synthesis-related genes AR,CYP17A1,CYP19A1,STAR,and NR5A1.Moreover,knockdown of NUP107 decreased the expression of AMHR2,FSHR,LHR,and ESR1 in GCs,but had no effect on the expression of ESR2.Conclusions:These data revealed that NUP107 may impede follicle growth and maturation by regulating hormone synthesis,sensitivity to follicle-stimulating hormone,and expression of functional receptors in GCs,and may,therefore,interfere with female fertility.
  • 摘要：Objective:Polycystic ovary syndrome(PCOS),a heterogeneous endocrine disorder,affects female reproductive function,but its etiology has not been elucidated.In this study,we analyzed the differential genes related to ovarian steroid biosynthesis in patients with PCOS,to explore the mechanism of PCOS.Methods:The GSE59456 data were downloaded from the Gene Expression Omnibus database.We identified differentially expressed genes(DEGs)in ovaries between the female Sprague-Dawley rats those implanted with 5α-dehydrotestestrone(DHT)and those in control(CTL,implanted with empty capsule).Gene ontology,pathway enrichment analysis,and protein-protein interaction(PPI)network construction were subsequently performed.Results:In total,530 upregulated DEGs and 522 downregulated DEGs were identified.The identified DEGs were mostly associated with steroid biosynthesis.In the PPI network,the module M1 was mainly related to steroid biosynthesis,and five genes(Hsd17b7,Tm7sf2,Idi1,Msmo1,and Sqle)of the module M1 were from the aforementioned group of upregulated genes.Furthermore,the 19 DEGs(Idi1,Cga,C1qb,Thy1,Gpx1,Ctss,Lpl,A2m,Cited2,Plppr4,Prkar2b,Slc44a1,Inha,Rbp4,Pla2g2a,Gata4,Fabp3,Cpa2,and Cpa1)between DHT and CTL groups were associated with the process of the transformation of primordial follicles to primary follicles.Conclusions:These DEGs,such as Hsd17b7,Tm7sf2,Idi1,Msmo1,Sqle,Rbp4,Gata4,Inha,and Cited2,may be used to elucidate the etiology of PCOS,which may provide new insights into the exploration of pathological mechanism and biomarkers for polycystic ovary.
  • 摘要：Currently-placed protocols for extended culture for in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI)are not uniformly standardized in determining the optimal stage of oocyte maturation for maximizing clinical outcomes.The objective of this systematic review is to elucidate the relationship between extended cumulus-oocyte culture and its effect on the clinical outcomes of IVF/ICSI.We included an electronic search on PubMed Central as well as the Journal of Fertility and Sterility to yield seven studies on extended oocyte culture for IVF/ICSI.Four of the seven investigations illustrate the promising beneficial relationship of extended culture with conditioned or supplemented media to mimic physiological uterine conditions.Three studies did not capture beneficial relationships between extended oocyte culture and clinical outcomes with unconditioned,unsupplemented maturation medium.Improvement in fertilization rates,oocyte development,and live birth rates may be achieved by extended culture with the addition of supplemental biochemicals.The usage of follicular fluid,cumulus cells,and meiotic inhibitors imitates the physiological in vivo conditions,whereas extended oocyte culture imitates in vivo temporal conditions.The conjunction of extended oocyte culture with supplemented metabolites,either added in maturation media manually or secreted by cumulus-oocyte complexes,mimics natural uterine physiological conditions to improve clinical outcomes for patients seeking IVF/ICSI.
  • 摘要：A young boy with a facial abnormality was brought to our genetics clinic.Physical examination found bilateral cryptorchidism.Several clinical genetic tests,including chromosome microarray analysis(CMA),karyotyping,and azoospermia factor(AZF)microdeletions on the Y chromosome,were used to identify the genetic basis for this abnormality.The karyotype showed a duplication of the chromosome 2q35q37.3 fragment attached to chromosome 9(p24);CMA revealed 2q35q37.3(220,558,895-243,006,013)x3;the Y chromosome showed no AZF microdeletions;and the parent karyotypes were normal.Surgery has been planned to correct cryptorchidism a year after the original examination.A similar case was found previously.
  • 摘要：Objective:Loop electrosurgical excision procedure(LEEP)is the first choice for patients with high-grade squamous intraepithelial lesion(HSIL).This study aimed to investigate postoperative fertility and sexual function in patients with HSIL after LEEP.Methods:This cohort study included patients with HSIL enrolled at 11 obstetrics and gynecology hospitals between January 1,2013,and December 31,2015.The patients were treated with LEEP only.Ultimately,760 patients meet our inclusion and exclusion criteria.Our research included two parts:The effect of LEEP on postoperative fertility and the effect of LEEP on postoperative sexual function.In the two different parts of the research,we chose different case series according to their follow up information.Results:In the LEEP group,125 patients had successful deliveries and 27 were preterm(21.6%).The risk of preterm birth was significantly higher in the case group(relative risk[RR]:2.634;95%confidence interval[CI]:1.689-4.108).As the cone depth and volume increased,the risk of preterm increased.In this study,the raw relative risk of cesarean section(CS)was increased in the LEEP group,however the constituent ratio of the indications in the LEEP group was not significantly different from that of the control group.With increased cone depth and volume,pain during postoperative sexual intercourse gradually increased.Conclusions:LEEP increases the risk of preterm birth.The risk increases as the cone depth and volume increases.LEEP could lead to pain during sexual intercourse.
  • 摘要：Objective:This study aimed at elucidating the therapeutic effectiveness of metformin in polycystic ovary syndrome(PCOS)patients with normal clinical indices of insulin sensitivity.Methods:This study was a retrospective cohort study.Based on their homeostasis model of assessment of insulin resistance(HOMA-IR)results,PCOS patients(n=113)were allocated to either the IR Group(IR,HOMA-IR>2.69)or the non-IR Group(NIR,HOMA-IR≤2.69).Metformin was administered to all patients,and their medical history,menstrual status,and endocrine and metabolic characteristics were obtained before and after treatment.The one-way analysis of variance was used to determine the differences between the IR and NIR groups.The paired t-test was used to determine the differences between pre-and posttreatment results.Results:Analyses of baseline characteristics showed that the incidence of IR and glycolipid metabolism is higher within elder PCOS patients.Metformin improved menstrual cycle and ovulation rate in NIR patients,similar to those in IR patients.In the NIR group,metformin decreased luteinizing hormone(LH)levels,free androgen index(FAI)levels,body mass index,and waist circumference,but had no obvious effect on glucose,insulin,and lipid profiles.Whereas in the IR group,metformin not only decreased LH and FAI levels,but also improved glycolipid metabolism.Conclusions:The effect of metformin on PCOS patients with normal insulin sensitivity index suggests that the mechanism of menstrual improvement may not be related to IR.In addition,metformin can improve glycolipid metabolism.Therefore,metformin is suitable for long-term treatment of PCOS and should be more widely used.
  • 摘要：Objective:This study aimed to compare the efficacy of clomiphene citrate(CC)with human menopausal gonadotropin(hMG)and that of medroxyprogesterone acetate(MPA)with hMG in poor responders defined according to the Bologna criteria.Methods:The data of patients with poor ovarian response(POR)according to the Bologna criteria from September 2016 to November 2017 were retrospectively reviewed.All participants received either CC+hMG or the progesterone-primed ovarian stimulation protocol(PPOS)protocol.Results:A total of 340 patients and 563 in vitro fertilization cycles were analyzed in this study.The incidence of spontaneous luteinizing hormone(LH)surge and the mean LH level on trigger day were significantly lower in the PPOS group than in the CC+HMG group(0.04%vs.3.49%and 4.26±3.59 vs.9.38±6.92 mIU/mL,respectively,P<0.05);however,the incidence of premature ovulation was similar between the two groups.The number of viable embryos harvested was not statistically different between the two groups(1.7±1.1 vs.1.5±0.8,P=0.06).The mean dose and duration of hMG were significantly higher in the PPOS group than in the CC+hMG group(908.7±556.6 vs.177.9±214.5 IU and 6.0±3.4 vs.1.2±1.5 days,respectively,P<0.05).However,the number of oocytes retrieved,number of metaphase II oocytes,and fertilization rate were comparable between the two groups.Conclusions:The CC with low-dose gonadotropin strategy was superior to the MPA with hMG protocol for POR.
  • 摘要：Pregnancy is a complicated process with intricate cell-to-cell crosstalk and immune regulation.Decidual natural killer(NK)cells account for 50%-70% of decidual immune cells in early pregnancy,suggesting that they play important roles in various events,such as embryo implantation and vascular remodeling.Many studies have shown that decidual NK cells interact with other cells either through direct contact or the secretion factors such as cytokines and chemokines.Hence,this review aimed to present the phenotypic characteristics,classification,and functions of decidual NK cells at the maternal-fetal interface during pregnancy.
  • 摘要：Endometriosis(EMS)is a common gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity.It is commonly associated with pelvic pain and infertility.The exact pathogenesis remains unclear and many hypotheses have been suggested.In recent years,accumulating evidence indicates that oxidative stress(OS)plays a role in the development of EMS.The treatment of EMS remains a challenge.Antioxidant therapies for effective management of reactive oxygen species and inflammation have generated considerable research interest.Antioxidant agents such as Vitamins C and E,resveratrol,curcumin,melatonin,epigallocatechin-3-gallate,and others have been studied for the treatment of EMS.This review presents the role of OS in pathophysiology of EMS and the antioxidant therapies in its management.
  • 摘要：Cyclooxygenase-2(COX-2)is a rate-limiting enzyme in arachidonic acid(AA)metabolism.COX-2 and its products(prostanoids)serve versatile biological functions during pregnancy.Numerous evidences demonstrate special reprogramming of COX-2-catalyzing AA metabolism in decidual immune cells(DICs),particularly in decidual macrophages,corresponding to special gestational phases.This review summarizes the reprogramming of COX-2-catalyzing AA metabolism in DICs as well as the immunoregulation of diverse COX-2-generating prostanoids in DICs during the different phases of gestation.
  • 摘要：Polycystic ovary syndrome(PCOS)is a common endocrine disorder characterized by reproductive and metabolic dysfunction with a genetic predisposition evidenced by familial clustering and twin studies.Patients with PCOS often produce oocytes of poor quality,leading to lower rates of fertilization,cleavage,and implantation,but higher rates of miscarriages and long-term complications.However,the etiology of PCOS still remains uncertain due to unavailability of unified diagnostic criteria and prevalence of clinical heterogeneity.Owing to advances in technology and methods employed for research,large-scale genetic/other studies have provided many new insights into the genetic pathogenesis of PCOS.However,although genome-wide association studies have been conducted,we still need to evaluate the association between specific loci and their relevance in the manifestation of this disease.In this article,we have presented a review of the recent studies.
  • 摘要：The incidence of recurrent spontaneous abortion(RSA)in women of reproductive age is 1%-5%,which is a heavy physical and emotional blow to these women.Repeated curettage of uterine cavity will damage the endometrium,causing partial infection and leading to intrauterine adhesion(IUA).Repeated pregnancy loss causes a huge emotional trauma to both the patients and their families,including negative emotions,such as anxiety,stress,and frustrations.Therefore,patients with RSA are eager to seek medical help from their doctors before pregnancy again.However,the causes of RSA are complicated,with 50%of cases having unexplained etiologies.
  • 摘要：Objective:Endometriosis is a common gynecological disease with an enigmatic pathogenesis.Recent studies suggest that the behavior of normal endometrial stromal cells can dramatically change under hypoxic conditions,which effectively turns them into endometriotic stromal cells.Because menstrual debris is not only hypoxic but may also contain platelet aggregates,at present,we aimed to approve that activated platelets could induce hypoxia-inducible factor-1α(HIF-1α)expression in endometrial stromal cells,signaling the presence of hypoxia.Methods:We evaluated the gene and protein expression levels of HIF-1α and its target gene erythropoietin(EPO)in both human endometriotic stromal cells(HESCs)and a human endometrial stromal cell line(ESCL)cocultured with or without activated platelets for 48 h.Results:We found that the gene and protein expression levels of HIF-1α and EPO in both HESC and ESCL were significantly increased after coculture with activated platelets.We also found that neutralization of transforming growth factor-β1 completely abolishes this induction.Conclusions:Platelets can induce a hypoxic state in endometrial and endometriotic stromal cells,resulting in increased angiogenesis,as well as enhanced survival and proliferation.In conjunction with other roles that platelets play in the development of endometriosis,our findings further highlight the important roles of platelets in the development and initiation of endometriosis,shedding new light into the etiology of endometriosis.
  • 摘要：Objective:To develop a nomogram to predict the probability of live birth on the basis of the association of patient characteristics in subfertile individuals or couples.Methods:A retrospective study was conducted from January 2014 to December 2015.A nomogram was built from a training cohort and tested on an independent validation cohort.A total of 2,257 patients who had undergone their first nondonor cycle of in vitro fertilization(IVF)(including intracytoplasmic sperm injection)were randomly split 2:1 into training(n=1,527)and validation(n=730)cohorts.Results:There were no statistically significant differences in the patients’baseline and cycle characteristics between the training and validation cohorts.On multiple logistic regression analysis,female age,antral follicle count,tubal factor,anovulation,ethnicity,unexplained fertility,and male factor were significantly associated with live birth.The nomogram had a C-index of 0.700(95%confidence interval[CI]:0.698-0.701)in the training cohort and 0.684(95%CI:0.681-0.687)in the validation cohort.Conclusions:Our nomogram can predict the probability of live birth for infertile women and can be used to guide clinicians and couples to decide on an IVF treatment option.
  • 摘要：Objective:The transcriptional profile of cumulus cells(CCs)during oocyte maturation provides information for predicting oocyte developmental competence.Our previous study using a mouse model indicated that there were nine different genes related to oocyte development potential expressed in CCs during oocyte maturation.The purpose of this study was to elucidate whether gene expression levels of CCs during oocyte maturation are associated with oocyte developmental competence.Methods:The human CCs collected from each oocyte were divided into two groups after tracking depending on whether or not they developed to the blastocyst stage:(1)the oocytes were developed to blastocyst stage after fertilization(B+)and(2)the oocytes were not developed to blastocyst stage after fertilization(B−).The expression levels of the nine selected genes(ARRB1,ATP2C1,CDH5,CNTNAP1,LGR4,MKLN1,RHOBTB1,SIX2,and SMC2)were examined.CCs were obtained from 29 women who were undergoing intracytoplasmic sperm injection treatment cycles.Quantitative reverse transcriptase-polymerase chain reaction analysis was performed on cumulus masses collected before insemination.Each sample was run three times.Statistically significant differences in mRNA expression of the target genes in independent samples were evaluated by two-tailed Student’s t-test,and P<0.05 was considered significantly different.Results:There were significant differences in the mRNA expression levels of ARRB1(P=0.016),LGR4(P=0.025),and SMC2(P=0.013)between the groups B+and B−.Gene expression of ARRB1,LGR4,and SMC2 in CCs is related to blastocyst development.Conclusions:Analysis of expression of ARRB1,LGR4,and SMC2 genes in CCs as biomarkers may provide predictive information on oocyte developmental competence before insemination and fertilization.
  • 摘要：Objective:The study objective was to investigate the effects of luteinizing hormone(LH)supplementation on ovarian response and assisted reproductive technology(ART)outcomes in in vitro fertilization/intracytoplasmic sperm injection cycles with a gonadotropin(Gn)-releasing hormone antagonist protocol.Methods:This is a meta-analysis,and nine published randomized controlled trials(1,685 patients)were included.Continuous data were extracted in the form of mean±standard deviation and population size,whereas dichotomous data were extracted in the form of odds ratio.Results:The total amount of follicle-stimulating hormone(FSH)used,the duration of stimulation(DOS),the number of eggs in MII stage,the total number of formed embryos,the clinical pregnancy rate,and live birth rates were similar between groups,but the estrogen level on the day of human chorionic Gn(hCG)administration was slightly higher in the LH supplementation group.On subgroup analysis,it was reported that the addition of LH could significantly increase estrogen levels on the day of hCG administration in patients older than 35 years,and LH supplementation starting on the day of FSH administration may slightly extend the DOS.Moreover,regardless of the timing of LH supplementation,an increase in estrogen levels was found on the day of hCG administration.Conclusions:LH supplementation of an antagonist protocol increases estrogen levels on the day of hCG administration,but does not increase the number of mature oocytes retrieved,and also fails to improve ART outcomes.
  • 摘要：Objective:To analyze clinicopathologic classification features of the cases that were diagnosed as missed abortion preoperatively but turn out to be hydatidiform mole(HM)postoperatively.Methods:A retrospective analysis was conducted on the patients who had a missed abortion in our hospital from 2017 to 2018.Clinical and pathological characteristics of different types of HMs were observed.Diagnostic value of karyotype in HM was discussed based on the karyotype analysis of villi chromosome.Results:A total of 278(11.2%)HM patients were misdiagnosed as missed abortion.Naked-eye detection rate of HM was 26.61%,and sensitivity of transvaginal ultrasound on HM was 7.91%.One hundred and forty-seven(52.88%)HM cases could not be genotyped via pathological hematoxylin and eosin(HE)staining.70 HM patients underwent P57 immunohistochemistry,which had guiding significance to the classification.In addition,the karyotype diagnosis of the tissues from 15 cases basically matched their P57 classifications.Conclusions:P57 should be listed as a routine test in hydatidiform pathological examination at the same time of HE staining,and what’s more,P57 expression is consistent with genotyping,which should be recommended for the patients with HM if observed by naked eye.
  • 摘要：Objective:This large-scale cross-sectional study aims to identify the characteristics of and risk factors associated with sexual repression among internal migrants in China.Methods:Between August 2013 and August 2015,a total of 8,669 internal migrants from four major cities in China(Beijing,Shanghai,Chengdu,and Chongqing)voluntarily participated in our study.They were interviewed,and the data on their demographic information,occupation,and sexual activities were collected.The Chi-square test and multiple logistic regressions were conducted to identify significant associations.A stepwise method was adopted for the selection of variables.Results:There were 3,597(41.49%)males and 5,072(58.51%)females in total.A higher percentage of males reported that they felt sexual repression compared to females(14.43%vs.9.21%).After adjusting for other covariates,the consequence was showed that male migrants working for more than 5 days were more likely to report sexual repression(odds ratio[OR]=1.40,P<0.05).Living in a collective dormitory with others was also a risk factor for male migrants.The longer males spent with their partners,the less sexual repression occurred(OR=0.94,P<0.05).Similarly,agricultural household registration status and working for more than 5 days increased the risk for sexual repression among female migrants(OR=1.41 and OR=1.46,respectively,P<0.05).Frequent and constructive communication also protected females against sexual repression(P<0.05).Well-educated females experienced relatively less sexual repression when compared to their counterparts with less education(P<0.05).Conclusions:Sexual repression was significantly associated with a few demographic,occupational,and sexual risk factors.Meaningful differences have been identified between male and female migrants.More effective intervention programs such as safeguard measures and welfare policies should be designed and implemented for a majority of female migrants and for those with agricultural household registration status.

    生殖与发育医学：英文版的期刊信息

    • 曾用名：生殖与避孕：英文版;生殖与避孕(英文版);Reproductive and Developmental Medicine;生殖与避孕（英文版）;Journal of Reproduction and Contraception;Reproduction and Contraception
    • 创刊时间：1989
    • 地区：CN
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    • 热门主题：PREGNANCY VITRIFICATION IMPROVES FETAL GUIDELINES ABORTION PREIMPLANTATION HUMAN ACE2 PROFILING
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      4

      Medicine:Obstetrics and Gynecology;Reproductive Medicine;

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