摘要:Objective:To explore and analyze the influence of Intrahepatic cholestasis of pregnancy of pregnancy outcome. Methods:The patients with ICP in our hospital during May 2003 to May 2013 were taken as case group, the patients without ICP in our hospital during the same period were taken as control group. The influence of Intrahepatic cholestasis of pregnancy of pregnancy outcome for perineonate and the pregnant were retrospectively analyzed. Results:512 patients with ICP were included in case group and 512 patients without ICP were included in control group. There were no significantly statistic difference between case and control group(P>0.05). The pregnant weeks and body weight of neonates of case group were lower than control group, the incidence of fetal distress in uterus, amniotic fluid, premature birth and cesarean delivery of case group were higher than control group, the differences were significantly statistic(P<0.05). Conclusion:ICP can increase the incidences of difficult labour and cesarean delivery, induce infant of low-birth weight, premature birth and fetal distress in uterus. Early diagnose, early treatment and pregnancy termination can decrease the mortality of perineonate and the pregnant.%目的:探讨和分析妊娠期合并肝内胆汁淤积症对妊娠结局的影响。方法:选择2003年5月至2013年5月我院收治的妊娠合并肝内胆汁淤积症患者进入病例组,另外选择同期住院的无胆淤症妊娠患者进入对照组,采用回顾性分析的方法,从围生儿、孕产妇和分娩方式等方面分析肝内胆汁淤积症对妊娠结局的影响。结果:共有512例患者进入病例组,选择512例同期住院的非合并肝内胆汁淤积症妊娠患者进入对照组。病例组与对照组在年龄、孕产次等方面差异无统计学意义(P>0.05);病例组产妇孕周小于对照组,新生儿体重小于对照组,差异有统计学意义(P<0.05);病例组胎儿宫内窘迫、羊水污染、早产、剖宫产的发生率均高于对照组,差异有统计学意义(P<0.05)。结论:肝内胆汁淤积症是妊娠期严重的并发症之一,可提高难产和剖宫产率,导致低体重儿、早产、胎儿宫内窘迫,做好产妇的早期诊断和早期治疗、必要时及时终止妊娠可降低胎儿的死亡率和产妇的并发症发病率,改善妊娠结局。