摘要:Objectives To study the expression of PTEN gene in endometrial cancers ,to clarify the relationship between the expression and the clinicopathological parameter. Methods The expression of PTEN in 34 samples of endometrial cancer tissues were detected by immunohistochemical stainings. Results The expresion of PTEN in endometrial cancers tissues was 32.35%.The positive rate in clinical cancer stages Ⅰ and Ⅱ~Ⅲ was 64.5% and 14.29% (P<0.01). The positive rate in the high, middle and low pathohistologic grading was 63.64%, 21.43% and 11.11%, respectively (P<0.05), 44% of the cases without and 0% of the cases with node metastasis showed positive for PTEN (P<0.05), Condusisons PTEN gene may play a role in the inhibitory effect on the growth invasion and metastasis of endometrial cancer.