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Identification of transformation products of antiviral drugs formed during biological wastewater treatment and their occurrence in the urban water cycle

机译:生物废水处理过程中形成的抗病毒药物转化产物的鉴定及其在城市水循环中的存在

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摘要

The fate of five antiviral drugs (abacavir, emtricitabine, ganciclovir, lamivudine and zidovudine) was investigated in biological wastewater treatment. Investigations of degradation kinetics were accompanied by the elucidation of formed transformation products (TPs) using activated sludge lab experiments and subsequent LC-HRMS analysis. Degradation rate constants ranged between 0.46 L d(-1) g(ss)(-1) (zidovudine) and 55.8 L d(-1) g(ss)(-1) (abacavir). Despite these differences of the degradation kinetics, the same main biotransformation reaction was observed for all five compounds: oxidation of the terminal hydroxyl-moiety to the corresponding carboxylic acid (formation of carboxy-TPs). In addition, the oxidation of thioether moieties to sulfoxides was observed for emtricitabine and lamivudine.
机译:研究了生物废水处理中五种抗病毒药物(阿巴卡韦,恩曲他滨,更昔洛韦,拉米夫定和齐多夫定)的命运。降解动力学的研究伴随着使用活性污泥实验室实验和随后的LC-HRMS分析阐明形成的转化产物(TPs)。降解速率常数介于0.46 L d(-1)g(ss)(-1)(齐多夫定)和55.8 L d(-1)g(ss)(-1)(阿巴卡韦)之间。尽管降解动力学存在这些差异,但对于所有五种化合物均观察到相同的主要生物转化反应:将末端羟基部分氧化为相应的羧酸(羧基TPs的形成)。另外,对于恩曲他滨和拉米夫定,观察到硫醚部分被氧化成亚砜。

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