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Carboplatin-Degradation Products Formed Under Deliberated and Non-deliberated Laboratory Experiments: Structural Elucidation

机译:在有意和无意的实验室实验下形成的卡铂降解产物:结构解析

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摘要

Carboplatin (CPT) is of undisputed relevance to cancer therapy. The formation of CPT degradation products (DPs) was studied in various aqueous solutions containing 100 μg/mL CPT. Three phosphate buffer solutions, at pH 4, pH 6, and pH 8, and three other solutions with the addition of NaCl, ammonia, and humic acids, were examined in deliberated and non-deliberated laboratory experiments. Nine CPT DPs were identified by their MS and UV spectra. Six (CPT1,5, 6, 7, 8 and 9) were produced following exposure to solar irradiation, and mainly obtained from (CPT4) in the presence of the appropriate nucleophiles. Calculation of the first-order kinetics processes of CPT degradation enabled understanding the reaction mechanism for CPT4 formation through the intermediate product [CPT-NH_3]~+. The detection and quantification of DPs of other investigated drugs is recommended as an integral part of any study, method, or technique dealing with pharmaceutical residues in aquatic environments.
机译:卡铂(CPT)与癌症治疗无可争议地相关。在各种含有100μg/ mL CPT的水溶液中研究了CPT降解产物(DPs)的形成。在有意和无意的实验室实验中检查了三种pH分别为4,pH 6和pH 8的磷酸盐缓冲液,以及其他三种添加了NaCl,氨水和腐殖酸的溶液。通过MS和UV光谱鉴定出9个CPT DP。六种(CPT1、5、6、7、8和9)暴露于太阳辐射后产生,主要在适当的亲核试剂存在下从(CPT4)获得。通过计算CPT降解的一级动力学过程,可以了解通过中间产物[CPT-NH_3]〜+形成CPT4的反应机理。建议将其他被调查药物的DPs进行检测和定量,作为处理水生环境中药物残留的任何研究,方法或技术的组成部分。

著录项

  • 来源
    《Water, Air, and Soil Pollution》 |2014年第12期|2195.1-2195.12|共12页
  • 作者单位

    The Hydro-Chemistry Laboratory, Department of Geography and Environmental Studies, Tel Aviv University, Tel Aviv 69978, Israel,The Porter School of Environmental Studies, Tel Aviv University, Tel Aviv 69978, Israel;

    The Hydro-Chemistry Laboratory, Department of Geography and Environmental Studies, Tel Aviv University, Tel Aviv 69978, Israel;

    The Hydro-Chemistry Laboratory, Department of Geography and Environmental Studies, Tel Aviv University, Tel Aviv 69978, Israel;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Carboplatin; Degradation product; Kinetics; Nucleophile; LC-MS-UV;

    机译:卡铂;降解产物;动力学;亲核的;LC-MS-UV;
  • 入库时间 2022-08-17 13:39:21

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