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Assessing the potential of skin electroporation for the delivery of protein-and gene-based druges

机译:评估皮肤电穿孔用于递送基于蛋白质和基因的药物的潜力

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摘要

Although transdermal drug delivery has many potential advantages, the permeability of skin to macromolecules is extremely low. However, the application of short, high-voltage pulses to electroporate skin has recently been shown to make it reversibly permeable. A number of studies have demonstrated that electroporation-mediated transdermal delivery of peptides, polysaccharides, oligonucleotides and genes may be possible at clinically relevant rates, leading to the current commercial development of electroporation techniques.
机译:尽管透皮药物递送具有许多潜在的优点,但是皮肤对大分子的渗透性极低。然而,近来已经证明,将短的高压脉冲施加到电穿孔的皮肤上使其可逆地渗透。大量研究表明,以临床相关的速率电穿孔介导的肽,多糖,寡核苷酸和基因的透皮递送是可能的,从而导致电穿孔技术的当前商业发展。

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