The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals

摘要

The desire to deliver protein and peptide biopharmaceuticals conveniently and effectively has led to intense investigation of site-specific drug-delivery systems. Despite challenges, progress towards the convenient noninvasive delivery of proteins and peptides has been achieved through specific routes of administration. In addition, the delivery of proteins and peptides to spe- cific sites of action has been utilized to lower the total delivered dose, to gain access to specific organs or body compart- ments and to concentrate a therapeutic dose at a specific site of pharmacological action.