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Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents

机译:将旧药转化为新疗法:核糖体移码作为抗病毒药物的靶标

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Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production. Ribosomal Frameshifting therefore provides a unique target on which antiviral agents can function. This article describes a series of Rapid assay strategies that have been developed and used to identify potential antiviral agents that target programmed
机译:许多病毒使用程序化核糖体移码来调节结构蛋白和酶蛋白的产生。改变移码效率会破坏病毒的生命周期,并消除或减少病毒的产生。因此,核糖体移码提供了抗病毒剂可以发挥作用的独特靶标。本文介绍了一系列快速测定策略,这些策略已被开发并用于鉴定靶向已编程的潜在抗病毒药物

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