Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer Therapy and diagnosis

摘要

Recombinant immunotoxins are new agents being developed for cancertherapy. They are composed of Fv fragments of anti- bodies that bind to cancer cells fused to a truncated form of a very potent bacterial toxin. The antibody moiety directs the toxin to cancer cells, which are killed, while normal cells are not recognized and thus survive. The excellent preclinical results in vitro and in vivo have led to the initiation of several clinical trials.