The validity of predicted T-cell epitopes

摘要

High-performing MHC class I binding predictions have been available for more than a decade;however,their value in terms of actual epitope finding has only now been estimated in a large-scale investigation undertaken by the group of Sette.This work underlines the importance of bioinformatics as a resource-saving tool in the field of epitope discovery.In addition,the data can be used to benchmark the performance of other new or existing CTL epitope-prediction tools.