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Molecular imaging of cell-mediated cancer immunotherapy.

机译:细胞介导的癌症免疫疗法的分子成像。

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New strategies based on the activation of a patient's immune response are being sought to complement present conventional exogenous cancer therapies. Elucidating the trafficking pathways of immune cells in vivo, together with their migratory properties in relation to their differentiation and activation status, is useful for understanding how the immune system interacts with cancer. Methods based on tissue sampling to monitor immune responses are inadequate for repeatedly characterizing the responses of the immune system in different organs. A solution to this problem might come from molecular and cellular imaging - a branch of biomedical sciences that combines biotechnology and imaging methods to characterize, in vivo, the molecular and cellular processes involved in normal and pathologic states. The general concepts of noninvasive imaging of targeted cells as well as the technology and probes applied to cell-mediated cancer immunotherapy imaging are outlined in this review.
机译:寻求基于患者免疫应答激活的新策略来补充目前的常规外源性癌症疗法。阐明体内免疫细胞的运输途径,以及与它们的分化和激活状态有关的迁移特性,对于理解免疫系统如何与癌症相互作用非常有用。基于组织采样来监测免疫反应的方法不足以重复表征不同器官中免疫系统的反应。这个问题的解决方案可能来自分子和细胞成像-生物医学科学的一个分支,结合了生物技术和成像方法以体内表征正常和病理状态下涉及的分子和细胞过程。本文概述了靶细胞非侵入性成像的一般概念,以及应用于细胞介导的癌症免疫疗法成像的技术和探针。

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