Mastering the complexity of DNA nanostructures

摘要

The self-assembly of oligodeoxynucleotides is a versatile and powerful tool for the construction of objects in the nanoscale.The strictly information-driven pairing of DNA fragments can be used to rationally design and build nanostructures with planned topologies and geometries.Taking advantage of the steadily expanding library of well-characterized DNA motifs,several examples of structures with different dimensionalities have appeared in the literature in the past few years,laying the foundations for a promising DNA-mediated,bottom-up approach to nanotechnology.This article focuses on recent developments in this area of research and proposes a classification of DNA nanostructures based on topological considerations in addition to describing strategies for tackling the inherent complexities of such an endeavor.