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The Canonical Network of Autotrophic Intermediary Metabolism: Minimal Metabolome of a Reductive Chemoautotroph

机译:自养中介代谢的规范网络:最小化的代谢自养生物的代谢组。

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摘要

Chemoautorophs that fix carbon by the reductive tricarboxylic acid cycle represent one of the dominant bacterial life forms that make a major contribution to biomass production. From the viewpoint of biogenesis, construction of a canonical chart of intermediary metabolism for this class of organisms may help us to understand early cellular evolution and point us to the last universal common ancestor. Data-mining the KEGG Pathways database enabled us to integrate required biosynthetic pathways and derive a chart that represents the complete anabolic network of a reductive chemoautotroph. Compounds of this metabolic network together constitute a representative minimal metabolome that comprises 287 metabolites. These compounds have been classified into different groups including those compounds that form nodes in the network. It can be seen that a relatively sparse set of organic chemical reactions dominate the anabolic synthesis in the assembly of the minimal autotrophic metabolome. Empirical generalizations that result from analyzing this metabolic network may aid in elucidating selection rules that govern its emergence and further evolution and may also help in delineating attributes that impart the observed robustness to these metabolites. [PUBLICATION ABSTRACT]
机译:通过还原性三羧酸循环固定碳的化学自卫队代表了占主导地位的细菌生命形式之一,对生物质的生产做出了重大贡献。从生物发生的观点来看,为这类生物体建立中间代谢的规范图可能有助于我们了解早期的细胞进化,并为我们指出最后一个普遍的祖先。 KEGG Pathways数据库的数据挖掘使我们能够集成所需的生物合成途径,并得出代表还原型化学自养生物的完整合成代谢网络的图表。该代谢网络的化合物一起构成了一个代表性的最小代谢组,该代谢组包含287种代谢物。这些化合物已分类为不同的组,包括在网络中形成节点的那些化合物。可以看出,在最小的自养代谢组的装配中,相对稀疏的有机化学反应占主导地位。通过分析该代谢网络得出的经验总结可以帮助阐明决定其出现和进一步进化的选择规则,还可以帮助描述赋予这些代谢物鲁棒性的属性。 [出版物摘要]

著录项

  • 来源
    《The Biological Bulletin》 |2009年第2期|p.126-130|共5页
  • 作者单位

    VUAY ASARATHY SRINIV ASAN* AND HAROLD J. MOROWTTZKrasnow Institute for Advanced Studies, George Mason University, Fairfax, Virginia 22030Received 12 September 2008, accepted 26 November 2008.* To whom correspondence should be addressed: E-mail: vsriniva@gmu.edu,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
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  • 入库时间 2022-08-17 23:33:21

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