in Vivo Evaluation of Percutaneous Absorption by Photoacoustic Method -Development of practical apparatus and its application to human skin-

摘要

A photoacoustic (PA) method to human skin made possible to obtain important information about percutane- ous absorption. But it was difficult to measure PA signals in vivo at any wavelength or at any modulation fre- quency we need. We built a practical apparatus with a high-sensitivity open-ended PA cell and an appropriate optical design. Using this apparatus, we could detect high-S/N PA signals in the 270 to 700nm wavelength range and in the 50 to 1,000Hz modulation-frequency range.