A 64 Channel Programmable Closed-Loop Neurostimulator With 8 Channel Neural Amplifier and Logarithmic ADC

摘要

This paper describes a neurostimulation IC for use in advanced closed-loop neurostimulation applications, such as deep brain stimulation (DBS) for treatment and research of neurological disorders including Parkinson's disease. This system senses and filters neural activity with eight pre-amplifiers, a 200 kS/s 8-bit log ADC and digital filters and incorporates 64 programmable current-stimulation channels. The entire device, implemented in 0.18 $mu{hbox {m}}$ CMOS, occupies 2.7 ${hbox {mm}}^{2}$ and consumes 89 $mu{hbox {W}}$ in normal operation mode and 271 $mu{hbox {W}}$ in configuration mode from a 1.8 V supply.