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The Geographic Distribution of Genetic Risk as Compared to Social Risk for Chronic Diseases in the United States

机译:与美国慢性病的社会风险相比,遗传风险的地理分布

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摘要

There is an association between chronic disease and geography, and there is evidence that the environment plays a critical role in this relationship. Yet at the same time, there is known to be substantial geographic variation by ancestry across the United States. Resulting geographic genetic variation—that is, the extent to which single nucleotide polymorphisms (SNPs) related to chronic disease vary spatially—could thus drive some part of the association between geography and disease. We describe the variation in chronic disease genetic risk by state of birth by taking risk SNPs from genome-wide association study meta-analyses for coronary artery disease, diabetes, and ischemic stroke and creating polygenic risk scores. We compare the amount of variability across state of birth in these polygenic scores to the variability in parental education, own education, earnings, and wealth. Our primary finding is that the polygenic risk scores are only weakly differentially distributed across U.S. states. The magnitude of the differences in geographic distribution is very small in comparison to the distribution of social and economic factors and thus is not likely sufficient to have a meaningful effect on geographic disease differences by U.S. state.
机译:慢性病和地理之间存在关联,并且有证据表明环境在这种关系中起着至关重要的作用。但是,与此同时,在美国,祖先的地理分布也存在很大差异。最终的地理遗传变异(即与慢性病相关的单核苷酸多态性(SNP)在空间上的变化程度)因此可以驱动地理与疾病之间的某种关联。我们通过从全基因组关联研究的冠心病,糖尿病和缺血性中风的荟萃分析中获取风险单核苷酸多态性(SNP),并通过建立多基因风险评分,描述了出​​生时慢性疾病遗传风险的变化。我们将这些多基因评分中不同出生状态的变异性与父母教育,自己的受教育程度,收入和财富的变异性进行了比较。我们的主要发现是,多基因风险评分在美国各州之间的分布微弱。与社会和经济因素的分布相比,地理分布差异的大小很小,因此可能不足以对美国各州的地理疾病差异产生有意义的影响。

著录项

  • 来源
    《Social Biology》 |2016年第1期|126-142|共17页
  • 作者单位

    School of Medicine, Division of General Medical Disciplines, Stanford University, Stanford, California, USA;

    Graduate School of Education, Stanford University, Stanford, California, USA;

    School of Medicine, Division of General Medical Disciplines, Stanford University, Stanford, California, USA;

  • 收录信息 美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 03:45:00

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