Simulating HIV-1 Protease at its Most Vulnerable Instant

摘要

In the race to fight AIDS, researchers have long worked to view the moments at which critical components of the HIV virus are most vulnerable to new drugs. Due to its central role in processing viral polypep-tide precursors, HIV-1 protease (HIV-PR), a molecule that slices the pre-HIV protein chain into pieces that ultimately evolve into a mature virus, continues to be one of the primary targets of anti-AIDS drug discovery.