The New Genomics: Global Views of Biology

摘要

The Human Genome Project was designed as a three-step program to produce-genetic maps, physical maps, and, finally, the complete nucleotide sequence map of the human chromosomes. In the past year, the first two milestones have essentially heen reachedand pilot sequencing projects have hegun with the aim of increasing speed and efficiency. Although only 1% of the humari genome has heen sequenced so far, there is growing confidence that the annual production rate can climb over the next 3 years to more than 500 megabases (Mb) worldwide--ensuring that the goal 'will be comfortably reached by the original, projection of 2005. The mouse, the leading biomedical model system, can likely be sequenced in parallel, although funding has not yet heen committed.