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REPLICATION OF HIV-1 IN DENDRITIC CELL-DERIVED SYNCYTIA AT THE MUCOSAL SURFACE OF THE ADENOID

机译:HIV-1在树突状细胞黏膜表面树突状细胞衍生的合胞体中的复制

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Human immunodeficiency virus-type 1 (HIV-1) replicates actively in infected individuals, yet cells with intracellular depots of viral protein are observed only infrequently. Many cells expressing the HIV-1 Gag protein were detected at the surface of the nasopharyngeal tonsil or adenoid. This infected mucosal surface contained T cells and dendritic cells, two cell types that together support HIV-1 replication in culture. The infected cells were multinucleated syncytia and expressed the S100 and p55 dendritic cell markers. Eleven of the 13 specimens analyzed were from donors who did not have symptoms of acquired immunodeficiency syndrome (AIDS). The interaction of dendritic cells and T cells in mucosa may support HIV-1 replication, even in subclinical stages of infection.
机译:人类免疫缺陷病毒1型(HIV-1)在受感染的个体中积极复制,但很少观察到带有病毒蛋白细胞内贮库的细胞。在鼻咽扁桃体或腺样体表面检测到许多表达HIV-1 Gag蛋白的细胞。受感染的粘膜表面含有T细胞和树突状细胞,这两种细胞类型共同支持培养中的HIV-1复制。感染的细胞为多核合胞体,并表达S100和p55树突状细胞标记。分析的13个样本中有11个来自没有后天免疫机能丧失综合症(AIDS)症状的供体。即使在亚临床感染阶段,粘膜中树突状细胞与T细胞的相互作用也可能支持HIV-1复制。

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