A Magnetic Attraction to High-Throughput Genomics

摘要

In the two decades since the invention of DNA sequencing, only a tiny fraction of the human genome has been decoded— about 1% of the 3000 mega-base pair (Mbp) total. It is therefore somewhat daunting to consider that the Human Genome Project has committed to completing the remaining 99% of the sequence by the year 2005 (1). This will require an unprecedented increase in sequencing capability, with a handful of genome centers needing to produce a combined throughput of 500 Mbp per year.