The Crystal Structure of a T Cell Receptor in Complex with Peptide and MHC Class II

摘要

The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign peptide antigen, and the I-A~K self major histocompatibility complex (MHC) class II molecule is reported at 3.2 angstrom resolution. The D10 TCR is oriented in an orthogonal mode relative to its peptide-MHC (pMHC) Ligand, necessitated by the amino-terminal extension of peptide residues pro- Jecting from the MHC class II antigen-binding groove as part of a mini β sheet.