Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

摘要

Activation of the protein kinase Raf can lead to opposing cellular responses such as proliferation, growth arrest, apoptosis, or differentiation. Akt (protein kinase B), a member of a different signaling pathway that also regulates these re- Sponses, interacted with Raf and phosphorylated this protein at a highly con- Served serine residue in its regulatory domain in vivo.