Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

摘要

Extracellular signals often result in simultaneous activation of both the Raf- MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated protein kinase or ERK kinase, and PI3K is phospha- Tidylinositol 3-kinase). However, these two signaling pathways were shown to Exert opposing effects on muscle cell hypertrophy.