HIV-1 Evolution and Disease Progression

摘要

Steven M. Wolinsky et al. studied the evolution of human immunodeficiency virus (HIV) in six infected patients with variable rates of disease progression and have represented their findings as inconsistent with our evolutionary hypothesis of HIV disease progression, also known as "an-tigenic diversity threshold theory". Their account of our model is, however, incorrect. Consequently their interesting and important data do not falsify our theory. We proceed to give a short review of our theory and show that the findings of Wolinsky et al. provide further evidence that the major assumptions of our evolutionary theory of HIV infection are valid.