Chiral-Selective Aminoacylation of an RNA Minihelix

摘要

Aminoacylation of RNA is a first step in protein synthesis and thus was critical for the transition from the putative RNA world to the theater of proteins. All natural proteins are composed of L-amino acids. Aminoacylation of a dinucleo-side monophosphate with the imidazolides of amino acids has shown that some aminoacyla-tion products are enriched for the L-, some for the D-, and others for no specific enantiomer. Thus, the question of chiral selectivity in natural proteins remains unanswered.