Picking Apart the Causes of Mysterious Dementias

摘要

Researchers are identifying the genetic and biochemical underpinnings of frontotemporal lobar dementias, incapacitating and ultimately fatal conditions. As we grow older, we face a host of diseases that can rob us of our mental vigor. Alzheimer's is the best known of these neurodegenerative diseases, but others can be just as devastating. Take the group of diseases collectively known as the frontotemporal lobar dementias (FTLDs). As the name suggests, these conditions stem from degeneration in the frontal and temporal lobes of the brain, areas that control behavior, emotions, and language. The symptoms, which usually develop when people are in their 50s or early 60s, include language difficulties and inappropriate behavior. Patients with early-stage FTLD typically can't control their impulses and may shoplift, overeat, and show excessive interest in sex. A decline in personal hygiene is also a frequent symptom.