Harmonization of Animal Care and Use Guidance

摘要

Societal expectations for improvements in the health of humans and animals require scientific studies involving the use of animals. At the same time, the public is concerned about the welfare of animals used in science. Animal welfare is also of importance because of the link between healthy, well-cared-for animals and sound science. Most national oversight mechanisms emphasize basic principles of humane science, in particular the "three R's" tenet of replacement, reduction, and refinement of animaluse (1). However, the oversight of animal care and use occurs through a wide variety of local, national, and international mechanisms, some based on legislation [the European Union (EU); (2)], others on peer review or other forms of nonlegislated oversight (Canada) and yet others on a combination of legislated and nonlegislated oversight (United States). This patchwork of mechanisms can cause problems, given the global nature of science.