Leptin Regulates Striatal Regions and Human Eating Behavior

摘要

Leptin is an adipocyte-derived circulating hormone that provides information to the brain about energy stores . The brain's response to leptin involves changes in energy expenditure and food intake. Leptin-deficient mammals, including humans, are markedly hyperphagic, and leptin replacement reverses this. However, there is little information about how higher brain centers integrate homeostatic signals such as leptin withrnimages of nonfood in the leptin-deficient and leptin-treated states. We used 10-cm visual analog scores to rate hunger, satiety, and the "liking" of food images. To examine the interaction with eating, we studied participants in fasted and fed states .