Activation of F0X01 by Cdk1 in Cycling Cells and Postmitotic Neurons

摘要

Activation of cyclin-dependent kinase 1 (Cdk1) has been linked to cell death of postmitotic neurons in brain development and disease. We found that Cdkl phosphorylated the transcription factor FOXO1 at Ser~(249) in vitro and in vivo. The phosphorylation o