Intrinsically Responsive

摘要

Members of the mitogen-activated protein kinase family regulate a wide range of biologi-rncal processes. Macia et al. have found that although the activity of the yeast mitogen-activated protein kinase (MAPK) Hogl, which helps yeast to survive osmotic stress, increases when yeast is exposed to high salt concentrations, the kinase appeared to be active under basal conditions. Inrnfact, signaling activity in thernabsence of stress was held in check by a negative feedback loop that required the kinase activity of Hogl.