Turning Off Inflammation Signaling

摘要

The name A20 may sound unassuming for a protein, but polymorphisms in the A20 gene locus have been identified as risk alleles for Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, psoriasis, and atherosclerosis, suggesting important functions for A20 protein in autoim-munity. A20 is also a tumor suppressor for several types of B cell cancer, including Hodgkin's lymphoma and diffuse large B cell lymphoma (1). On page 1135 of this issue, Shembade et al. describe the means by which A20 acts through the transcription factor nuclear fac-rntor κB (NF-κB) to control inflammation (2).