An RNA Mimic of DNA

摘要

RNAs-of the types known in the classical world as ribosomal, transfer, and messenger-are critical for the readout of DNA sequence into protein. On the other hand, numerous regulatory processes are governed by the modern upstarts known collectively as noncoding RNAs. Kino et al. have used a yeast two-hybrid screen to search for genes encoding binding partners for the DNA binding domain of the human glucocorti-coid receptor and come upon a noncoding RNA known as growth arrest-specific (Gas) 5, so-called because this single-stranded RNA accumulates in cells exposed to conditions that prevent growth. The glucocorticoid receptor is a ligand-acti-vated transcription factor, and Gas5 binds to the receptor, inhibiting its ability to activate its target genes.