Computer games? What a waste of time. And online multiplayer ones? Even more so. But hold on ... you clearly haven't heard about "Foldit." This free online game allows players (singly or in teams) to use simple tools (for example something the gamers know as shake, but which is in fact an automated combinatorial side chain rotamer packing tool) to fold polypeptide chains into chemically realistic three-dimensional protein structures. It is more than a useful education tool, though, as has been previously shown through the solution of the structure of a retroviral protease, and as Khatib et al. now further demonstrate.
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