Tracing the Common Roots of Antibiotic Resistance

摘要

For Roy Kishony, the usual way to study the evolution of antibiotic resistance doesn't apply enough pressure. Typically, researchers expose bacteria to a given concentration of antibiotic over multiple generations. But Kishony, a systems biologist at Harvard University, wanted to know how the microbes would respond if he kept upping the ante, subjecting them to ever-greater doses of these drugs and forcing them to continue to evolve to survive.