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Targeted Genome Editing Across Species Using ZFNs and TALENs

机译：使用ZFN和TALEN跨物种进行靶向基因组编辑

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摘要

Although entire genome sequences are available for numerous species, lack of reverse genetic tools has hindered cross-species comparisons of gene function. We demonstrate a widely applicable solution: targeted genome editing using site-specific nucleases.
机译：尽管整个基因组序列可用于许多物种，但是缺乏反向遗传工具阻碍了基因功能的跨物种比较。我们展示了一种广泛适用的解决方案：使用位点特异性核酸酶进行靶向基因组编辑。

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  • 来源
    《Science》 |2011年第6040期|p.307|共1页
  • 作者

    Andrew J. Wood; Te-Wen Lo; Bryan Zeitler; Catherine S. Pickle; Edward J. Ralston; Andrew H. Lee; Rainier Amora; Jeffrey C. Miller; Elo Leung; Xiangdong Meng; Lei Zhang; Edward J. Rebar; Philip D. Gregory; Fyodor D. Urnov; Barbara J. Meyer;

  • 作者单位

    Howard Hughes Medical Institute (HHMI), Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA;

    Howard Hughes Medical Institute (HHMI), Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Howard Hughes Medical Institute (HHMI), Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA;

    Howard Hughes Medical Institute (HHMI), Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Sangamo BioSciertces, Incorporated, Richmond, CA 94804, USA;

    Howard Hughes Medical Institute (HHMI), Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3204, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-18 02:54:02

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