Exosomes Deliver

摘要

Exosomes are small vesicles secreted from cells that can carry proteins and nucleic acids between cells. Alvarez-Erviti et al. have exploited this process to deliver specific RNAs to target cells that lie across a major obstacle: the mammalian blood-brain barrier. Exosomes were isolated from mouse dendritic cells. In order to ensure targeting to the brain, the protein Lamb2b, which is normally expressed by dendritic cells, was tagged with a sequence from rabies viral glycoprotein that binds to a receptor expressed in brain tissue.