FORENSIC TOXICOLOGY

摘要

The Strata-X-Drug B is a new solid phase extraction (SPE) sorbent specially designed and quality-control tested for drugs of abuse. Strata-X-Drug B, a polymeric strong cation-exchange SPE sorbent, does not require conditioning, saving time and solvent expense. Phenomenex has developed and tested three methods using the new sorbent that cover extraction of 11 drugs of abuse from six different Substance Abuse and Mental Health Services Administration (SAMHSA) drug classes. These simplified methods reduce training requirements, save lab technician time, and reduce the risk of user error. Strata-X-Drug B is quality-control tested using biological samples. Detection for all 11 common drugs of abuse is below the new, lower SAMHSA cutoff levels. The expected percent recovery has been calculated using LC/MS analysis of codeine and morphine extracted from urine. A second quality-control test confirms that the sorbent does not promote interconversion of norcodeine and normorphine to parent compounds, which can sometimes occur when using strong cation-exchange sorbents.