The Klebsiella pneumoniae Superbug (NDM-1) is now available through ATCC. Antibiotic-resistant, gram-negative bacteria including Klebsiella, Acinetobacter, Pseudomonas, and Escherichia coli isolates continue to emerge with increasing levels of drug-resistance due to horizontal transfer of known and novel resistance mechanisms, such as NDM-1. Isolates with NDM-1 have recently spread from India to Europe, to the United States, and to Japan. The newly available multidrug resistant, human clinical isolate Klebsiella pneumonia is positive for New Delhi metallo-|3-lactamase (NDM-1).The NDM-1 enzyme can inactivate all classes of p-lactams and all carbapenems, except for aztreonam, and this gene can easily transfer between bacterial species. The culture's genomic DNA is also available. The Klebsiella pneumoniae strain has the WaNDM-1 gene (confirmed by polymerase chain reaction [PCR] and nucleo-tide sequencing), and is negative for the WaKPC gene (confirmed by PCR).
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