Endocytosis In-filtration

摘要

A healthy human kidney filters about 180 liters of plasma per day, a highly regulated process that ensures the removal of toxins but the retention of proteins and red blood cells. Critical to this filtration process is the slit diaphragm, a cell-cell junction formed by specialized cells called podo-cytes that wrap around kidney capillaries. The slit diaphragm loses its structural and functional integrity in nephrotic syndrome, a disease characterized by protein loss in the urine (proteinuria) that can lead to kidney failure.