Immune Surveillance from Chromosomal Chaos?

摘要

In 1970, the cancer immune surveillance hypothesis proposed that "when aberrant cells with proliferative potential arise in the body, they will carry new anti-genic determinants on their surface. When a significant amount of new antigen has developed, a thymus-dependent immunological response will be initiated and eventually eliminates the aberrant cells" (1). This idea stirred much debate, and it remains unclear whether T cells spontaneously reject tumors or select variants of low immunoge- nicity.