Heart Brakes

摘要

Many of us are keenly aware of muscle diseases because they frequently impact our lives. Heart failure, for example, is a leading cause of death, and its hereditary link has focused research efforts on sequencing the genes encoding muscle proteins (1). Several muscle proteins are implicated in heart disease, most notably the abundant motor protein myosin, and the relatively scarce structural protein myosin binding protein C (MyBP-C). Myosin generates the force for heart muscle contraction, but a heart will pump without MyBP- C, and its role in contraction and disease was unknown.