Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells

摘要

Introduction: Cells use multilayered regulatory systems to respond adequately to changing environments or perturbations. Failure in regulation underlies cellular malfunctioning, loss of fitness, or disease. How molecular components dynamically interact to give rise to robust and adaptive responses is not well understood. Here, we studied how the model eukaryote Saccharomyces cerevisiae can cope with transition to high glucose levels, a failure of which results in metabolic malfunctioning and growth arrest.