Streamlining amine synthesis Bulky amine groups that help make many drugs more bioavailable can be added readily to organic compounds

Kuerti Laszlo

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Streamlining amine synthesis Bulky amine groups that help make many drugs more bioavailable can be added readily to organic compounds

机译：简化胺的合成可以很容易地将有助于使许多药物具有更高生物利用率的大容量胺基团添加到有机化合物中

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来源
《Science》 |2015年第6237期|863-864|共2页
作者
Kuerti Laszlo;
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作者单位

Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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入库时间 2022-08-18 02:52:02

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专利

1. Use of polymer supported reagents for clean multi-step organic synthesis: preparation of amines and amine derivatives from alcohols for use in compound library generation [J] . Ley SV., Hinzen B., Gervois AG., Journal of the Chemical Society, Perkin Transactions 1 . 1998,第15期

机译：聚合物支持的试剂用于清洁的多步有机合成中：从醇制备胺和胺衍生物，用于化合物库的生成
2. Synthesis, physicochemical properties, and amine-oxidation reaction of indolequinone derivatives as model compounds of novel organic cofactor TTQ of amine dehydrogenases [J] . Shinobu Itoh, Naoki Takada, Takeya Ando The Journal of Organic Chemistry . 1997,第17期

机译：新型胺脱氢酶有机辅因子TTQ的模型化合物吲哚醌衍生物的合成，理化性质和胺氧化反应
3. Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines [J] . Chen Fei-Fei, Zheng Gao-Wei, Liu Lei, ACS catalysis . 2018,第3期

机译：重塑胺脱氢酶的活性口袋，对庞大脂族胺的不对称合成
4. Small-molecule amine compound as electron-injection layer for organic light-emitting diodes [C] . Gang Liu, Yan-Hu Li, Wan-Yi Tan, Optical Processes in Organic Materials and Nanostructures. . 2012

机译：小分子胺化合物作为有机发光二极管的电子注入层
5. Part I. Development of new organic synthetic methods: Palladium and copper catalyzed carbon-carbon, carbon-sulfur, carbon-nitrogen, and carbon-oxygen bond formation as well as DABCO-mediated stereospecific synthesis of acrylate ethers and amines. Part II. Design, synthesis and SAR studies of new classes of agents to treat drug-resistant bacteria, anthrax and tuberculosis infections. [D] . Kabir, Mohd Shahjahan. 2011

机译：第一部分：新的有机合成方法的开发：钯和铜催化的碳-碳，碳-硫，碳-氮和碳-氧键的形成，以及DABCO介导的丙烯酸酯醚和胺的立体有择合成。第二部分新型药物的设计，合成和SAR研究，用于治疗抗药性细菌，炭疽和肺结核感染。
6. New Highly Charged Iron(III) Metal–OrganicCube Stabilized by a Bulky Amine [O] . Carlos Cruz, Andrés Igor Vega Carvallo, Evgenia Spodine, 2020

机译：新款带钢（III）金属 - 有机立方体被庞大的胺稳定
7. Metal-Mediated And Metal-Free Organic Transformations : C-H Functionalization Of Tertiary Amines, Synthesis Of Carbonyl Compounds And Ring-Opening Of Aziridines [O] . Alagiri K 2011

机译：金属介导和无金属的有机转化：叔胺的C-H功能化，羰基化合物的合成和氮丙啶的开环
8. Alkylation of Amines: A New Method for the Synthesis of Quaternary Ammonium Compounds from Primary and Secondary Amines [R] . Sommer, H. Z., Jackson, L. L. 1969

机译：胺的烷基化：从伯胺和仲胺合成季铵化合物的新方法

Streamlining amine synthesis Bulky amine groups that help make many drugs more bioavailable can be added readily to organic compounds

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